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Drug toxicology data are generally confidential due to their commercial value and consequently very little data are published in the scientific literature. This book therefore provides a unique opportunity to follow the detailed toxicology programmes for three drugs with information on how and when decisions were made to investigate key findings and to terminate development. Hypolipidaemic fibrates are a class of drugs developed for the treatment of lipid disorders in man. Toxicology studies have linked them with peroxisome proliferation and, in turn, liver cancer in rodents. This book provides a detailed record of regulatory studies carried out by ICI (now Zeneca) Pharmaceuticals on three fibrates, namely, clofibrate, methylclofenapate and clobuzarit. Comparative Toxicology of Hypolipidaemic Fibrates constitutes a comprehensive database on the long-term, acute and chronic toxicity of these compounds. Toxicologists will find details of the design of toxicity, teratogenicity and oncogenicity tests. Salient results of chemical pathology, pharmacokinetics and tissue pathology are presented, together with the predictions arising from these studies. Unique data in the book include 7-year studies and hepatotoxicity tests in many species.
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Previews available in: English
Subjects
Antilipemic agents, Biochemical toxicology, Chemotherapy, Clobuzarit, Clofenapate, Clofibrate, Drugs, Enzyme induction, Hypolipemia, Metabolism, Methylclofenapate, Peroxisomes, Toxicity, Toxicology, Xenobiotics, Medical toxicology, Reference, Technology, Science/Mathematics, Hypolipidemic Agents, Pharmakotherapie, Hypolipidämie, Drugs, toxicologyShowing 2 featured editions. View all 2 editions?
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1
COMP TOXICOL HYP0LIPID FIBRATES CL
June 1, 1995, Taylor & Francis
Hardcover
in English
- 1 edition
0748401377 9780748401376
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2
Comparative toxicology of hypolipidaemic fibrates
1995, Taylor & Francis
in English
0748401377 9780748401376
|
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Libraries near you:
WorldCat
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Book Details
Edition Notes
Includes bibliographical references (p. 93-95) and index.
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- Created October 9, 2008
- 3 revisions
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April 13, 2010 | Edited by Open Library Bot | Linked existing covers to the edition. |
December 15, 2009 | Edited by WorkBot | link works |
October 9, 2008 | Created by ImportBot | Imported from Oregon Libraries MARC record |