This volume illustrates the current lines of investigation of the angiogenic mechanisms based on contribution of circulating progenitor cells. The main themes that currently dominate this research field are: the origin of these cells, their tissue engraftment, their phenotypic modulation leading to the transformation into endothelial cells, etc. This volume is a key reference for angiogenesis researchers and students alike, in the fields of cardiovascular medicine, neoplastic disorders, wound management and tissue engineering, among others. Key Features: + Fresh data and concepts are presented to advance our understanding of basic angiogenic mechanisms. + Focuses entirely on an emerging paradigm able to supplement the old angiogenic mechanism, called the "sprouting" model, in accounting for all real-life situations. + Deals with the potential of progenitor cells to contribute to the maintenance and/or regeneration of tissues in an adult organism.