The Peruvian sociologist Aníbal Quijano is widely considered to be a foundational figure of the decolonial perspective grounded in three basic concepts: coloniality, coloniality of power, and the colonial matrix of power. His decolonial theorizations of these three concepts have transformed the principles and assumptions of the very idea of knowledge, impacted the social sciences and humanities, and questioned the myth of rationality in natural sciences. The essays in this volume encompass nearly thirty years of Quijano’s work, bringing them to an English-reading audience for the first time. This volume is not simply an introduction to Quijano’s work; it achieves one of his unfulfilled goals: to write a book that contains his main hypotheses, concepts, and arguments. In this regard, the collection encourages a fuller understanding and broader implementation of the analyses and concepts that he developed over the course of his long career. Moreover, it demonstrates that the tools for reading and dismantling coloniality originated outside the academy in Latin America and the former Third World.