MARC Record from harvard_bibliographic_metadata

LEADER: 04877nam a2200385 a 4500
001 012609002-5
005 20140121150840.0
008 101105s2011 nyua b 001 0 eng d
020 $a9781603271868
020 $a1603271864
035 0 $aocn678514802
040 $aHNC$cHNC
245 00 $aDrug safety evaluation :$bmethods and protocols /$cedited by Jean-Charles Gautier.
260 $aNew York, NY :$bHumana Press,$cc2011.
300 $axiii, 431 p. :$bill. ;$c27 cm.
490 1 $aMethods in molecular biology,$x1064-3745 ;$v691
490 1 $aSpinger protocols
504 $aIncludes bibliographical references and index.
530 $aAlso available in an electronic version.
538 $aMode of access: World Wide Web.
505 0 $aPart I General Toxicology -- Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, and Jeanne Stadler -- Part II Pathology -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette and Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui and Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, and William M. Gallagher -- Part III Genetic Toxicology -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Part IV Safety Pharmacology
505 8 $aManual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe -- Part V Investig ativ e Toxicology -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves and Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, and Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha El Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, and Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek and Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe -- Part VI Screening Ass ays for Developmental Toxicity.
505 8 $aFETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay -- Part VII Chemical Protein Adducts -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, and Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau -- One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau.
505 8 $aIdentification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau -- Part VIII Safety Biomarkers -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, and Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y.K. Lau, Stephen R. Pennington, and William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, and Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington.
650 22 $aToxicity Tests$xmethods.
650 22 $aDrug-Related Side Effects and Adverse Reactions.
650 12 $aDrug Evaluation, Preclinical$xmethods.
650 0 $aDrugs$xToxicology.
650 0 $aDrugs$xTesting.
655 7 $aComputer network resources.$2local
700 1 $aGautier, Jean-Charles.
830 0 $aMethods in molecular biology (Clifton, N.J.) ;$v691.
830 0 $aSpinger protocols.
988 $a20101108
906 $0OCLC