MARC Record from harvard_bibliographic_metadata

LEADER: 03218cam a2200469 a 4500
001 012883774-8
005 20120706192504.0
008 101118s2011 enka b 001 0 eng
010 $a 2010049113
016 7 $a101547862$2DNLM
020 $a9780199751754 (alk. paper)
020 $a0199751757 (alk. paper)
035 0 $aocn685111226
040 $aDNLM/DLC$cDLC$dYDX$dNLM$dYDXCP$dBWX
042 $apcc
050 00 $aQP363$b.M385 2011
060 00 $a2011 I-378
060 10 $aWL 11.1
082 00 $a616.8/047547$222
100 1 $aMcComas, Alan J.
245 10 $aGalvani's spark :$bthe story of the nerve impulse /$cAlan J. McComas.
260 $aOxford ;$aNew York :$bOxford University Press,$cc2011.
300 $axxiii, 391 p. :$bill. ;$c25 cm.
504 $aIncludes bibliographical references (p. 361-375) and index.
505 0 $aThe spark -- Catching up -- The anatomist's eye -- Cambridge, 1904 : the engineer -- The cathode ray oscilloscope -- The code -- Excitation and inhibition -- The messengers -- The squid giant axon -- The neuromuscular junction -- The giant axon impaled -- The war years -- Sodium unmasked -- The voltage clamp -- Aftermath -- Muscle : The new physiology -- More triumphs with microelectrodes -- The single ion channel -- Myotonic goats and migraines -- The swinging gate -- Departures.
520 $aGalvani's chronicles the gradual understanding of the nerve impulse which is the basis of all thoughts, sensations and actions. The story begins with Luigi Galvani's chance observation of a spark from a friction machine causing a frog's leg to twitch from across the room. The accurate recording and the understanding of the properties of the nerve fiber membrane that makes the impulse possible became the objectives of neuroscientists for over 200 years. The author, Alan J. McComas finely interweaves the stories, the challenges, and the controversies of the most prominent figures in neuroscience, from the histological descriptions of nerve cells by Cajal to the discovery of a three-dimensional structure of ion channels in cell membranes by MacKinnon. Along the way he details the first recordings of the impulse with a cathode ray oscilloscope by Gasser and Erlanger, Adrian's discovery that stimulus intensity is coded by the frequency of nerve impulses, and Hodgkin and Huxley's brilliant voltage clamp experiments, amongst many others.The recognition by Galvani that muscles and nerves have an electrical component triggered the field of neurophysiology and in turn has produced some of the greatest discoveries in neuroscience.
600 10 $aHuxley, Andrew,$d1917-2012.
650 0 $aNeural conduction$xResearch$xHistory.
650 0 $aNeural transmission$xResearch$xHistory.
650 0 $aAction potentials (Electrophysiology)$xResearch$xHistory.
600 12 $aHodgkin, A. L.$q(Alan L.)
650 12 $aNeurophysiology$xhistory.
650 22 $aAction Potentials.
650 22 $aHistory, 20th Century.
650 22 $aNervous System.
650 22 $aNeurophysiology$xinstrumentation.
600 12 $aHodgkin, A. L.$q(Alan Lloyd)
600 12 $aHuxley, Andrew,$d1917-2012.
899 $a415_565807
988 $a20110908
049 $aCLSL
906 $0OCLC