MARC Record from harvard_bibliographic_metadata

LEADER: 02218nam a2200349Ma 4500
001 013181641-1
005 20120608190626.0
008 100302s2009 maua b 000 0 eng d
035 0 $aocn555687580
040 $aUMM$cUMM
245 04 $aThe role of T cells in the regulation of acrolein-induced pulmonary inflammation and epithelial-cell pathology :$bwith a critique by the HEI Health Review Committee /$cMichael T. Borchers ... [et al.].
260 $aBoston, MA :$bHealth Effects Institute,$cc2009.
300 $avii, 42 p. :$bill. ;$c28 cm.
490 1 $aResearch report ;$vno. 146
500 $a"December 2009."
500 $a"Walter A. Rosenblith New Investigator Award research report."
504 $aIncludes bibliographical references.
505 1 $aMethods. Mice -- Acrolein exposure -- Bronchoalveolar lavage -- Cell and differential counts -- Tissue fixation, histology, and immunohistochemistry -- Quantification of mucous-cell metaplasia -- BAL mucin assay -- Lung-cell isolation and flow cytometry -- T-cell purification -- RNA isolation and amplification -- Experimental design of microarrays -- Microarray hybridization -- Microarray analysis -- Quantitative real-time PCR -- ELISA -- Statistical analysis -- Results. Acrolein-induced pulmonary pathology -- Injury to BAL epithelial cells -- Apoptosis of pulmonary epithelial cells -- Pulmonary inflammation -- Levels of macrophage mediators in the lung -- Purification of pulmonary lymphocytes -- Microarray data -- Cytokines and chemokines -- Discussion and conclusions. Effects of acrolein on pulmonary pathology -- Roles of [alpha][beta] T cells and [gamma][delta] T cells -- Transcriptional analysis of [alpha][beta] T cells and [gamma][delta] T cells.
650 12 $aT-Lymphocytes.
650 12 $aAcrolein$xtoxicity.
650 12 $aEpithelial Cells$xpathology.
650 12 $aPneumonia.
650 0 $aEpithelial cells.
650 0 $aT cells.
650 0 $aPneumonia.
650 0 $aAcrolein.
710 2 $aHealth Effects Institute.$bHealth Review Committee.
700 1 $aBorchers, Michael T.
710 2 $aHealth Effects Institute.
830 0 $aResearch report (Health Effects Institute) ;$vno. 146.
988 $a20120511
906 $0OCLC