MARC Record from harvard_bibliographic_metadata

LEADER: 03012nam a22003855a 4500
001 013716284-7
005 20130712193731.0
008 120913s2013 xxu| s ||0| 0|eng d
020 $a9781461448150
020 $a9781461448150
020 $a9781461448143
024 7 $a10.1007/978-1-4614-4815-0$2doi
035 $a(Springer)9781461448150
040 $aSpringer
050 4 $aRS380
050 4 $aRS190-210
072 7 $aTDCW$2bicssc
072 7 $aMED072000$2bisacsh
082 04 $a615.19$223
100 1 $aMüller, Markus.
245 10 $aMicrodialysis in Drug Development /$cedited by Markus Müller.
260 $aNew York, NY :$bSpringer New York :$bImprint: Springer,$c2013.
300 $aXI, 338 p. 55 illus., 29 illus. in color.$bdigital.
490 1 $aAAPS Advances in the Pharmaceutical Sciences Series,$x2210-7371 ;$v4
505 0 $aIntroduction to the Microdialysis Technology -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis -- Analytical Considerations for Microdialysis Sampling -- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations -- Microdialysis in Antibiotic Research -- Skin and Transdermal Drug Delivery: Advantages and Challenges -- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis -- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease -- Microdialysis in Pain Research -- Microdialysis in Ocular Drug Development -- Microdialysis in Metabolic Research -- High Molecular Weight Targets and Treatments Using Microdialysis -- Complementary Techniques – Positron Emission Tomography -- Open Flow Microperfusion: An Alternative Method to Microdialysis? -- Microdialysis in Internal Organs and Tumors.
520 $aIn vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
650 0 $aMedicine.
650 0 $aPharmaceutical technology.
650 14 $aBiomedicine.
650 24 $aPharmaceutical Sciences/Technology.
650 24 $aBiomedicine general.
776 08 $iPrinted edition:$z9781461448143
830 0 $aAAPS Advances in the Pharmaceutical Sciences Series ;$v4.
988 $a20130627
906 $0VEN