MARC Record from harvard_bibliographic_metadata

LEADER: 03330nam a22004575a 4500
001 013716347-9
005 20130712193746.0
008 130509s2013 xxu| s ||0| 0|eng d
020 $a9781461468288
020 $a9781461468288
020 $a9781461468271
024 7 $a10.1007/978-1-4614-6828-8$2doi
035 $a(Springer)9781461468288
040 $aSpringer
050 4 $aRC261-271
072 7 $aMJCL$2bicssc
072 7 $aMED062000$2bisacsh
082 04 $a614.5999$223
100 1 $aTindall, Donald J.
245 10 $aProstate Cancer :$bBiochemistry, Molecular Biology and Genetics /$cedited by Donald J. Tindall.
260 $aNew York, NY :$bSpringer New York :$bImprint: Springer,$c2013.
300 $aXII, 522 p. 41 illus., 38 illus. in color.$bdigital.
490 1 $aProtein Reviews ;$v16
505 0 $aPreface -- Section 1: Cell Biology -- Stem Cells in the Normal and Malignant Prostate -- Role of Reactive Stroma in Prostate Cancer -- The Role of Cholesterol in Prostate Cancer -- Section 2: Genetics: PTEN in Prostate Cancer -- ETS fusion genes in prostate cancer -- Section 3: Cell Signaling -- Signaling Mechanisms of Vav3, a Guanine Nucleotide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression -- Transforming Growth Factor-beta (TGF-b) in Prostate Cancer -- The p38 MAPK Pathway in Prostate Cancer -- NF-kappaB2/p52 in Prostate Cancer -- The functional role of DAB2IP, a homeostatic factor, in prostate cancer -- Tyrosine Kinases in Prostate Cancer -- Human prostatic acid phosphatase in prostate carcinogenesis -- Section 4: Hormonal -- Truncated Androgen Receptor Splice Variants in Prostate Cancer -- Biology and Clinical Relevance of Estrogen Receptors in Prostate Cancer -- Vitamin D and Prostate Cancer -- HDAC6 regulation of androgen signaling in prostate cancer -- Beyond the cell cycle: Implications of D-type cyclin deregulation in Pca -- Section 5: Cell Death -- Role of Par- in Prostate Cancer -- Autophagy and Prostate Cancer Therapeutics -- Index.
520 $aProstate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States.  The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.
650 20 $aCytology.
650 20 $aClinical biochemistry.
650 20 $aCancer$xResearch.
650 0 $aMedicine.
650 0 $aOncology.
650 0 $aBiochemistry.
650 0 $aCell receptors.
650 0 $aCytology.
650 14 $aBiomedicine.
650 24 $aProtein Science.
650 24 $aReceptors.
650 24 $aBiological Networks, Systems Biology.
776 08 $iPrinted edition:$z9781461468271
830 0 $aProtein Reviews ;$v16.
988 $a20130627
906 $0VEN