MARC Record from harvard_bibliographic_metadata

LEADER: 03941nam a22004215a 4500
001 013716421-1
005 20130712193805.0
008 130514s2013 gw | s ||0| 0|eng d
020 $a9783642366482
020 $a9783642366482
020 $a9783642366475
024 7 $a10.1007/978-3-642-36648-2$2doi
035 $a(Springer)9783642366482
040 $aSpringer
050 4 $aRC321-580
072 7 $aPSAN$2bicssc
072 7 $aMED057000$2bisacsh
082 04 $a612.8$223
100 1 $aGage, Fred H.
245 10 $aProgrammed Cells from Basic Neuroscience to Therapy /$cedited by Fred H. Gage, Yves Christen.
260 $aBerlin, Heidelberg :$bSpringer Berlin Heidelberg :$bImprint: Springer,$c2013.
300 $aXII, 130 p. 14 illus., 13 illus. in color.$bdigital.
490 1 $aResearch and Perspectives in Neurosciences,$x0945-6082 ;$v20
505 0 $aNuclear reprogramming by eggs and oocytes and eventual prospects of cell replacement therapy.- iPS technology and disease research: issues to be resolved -- ES and iPS cells as tools for modeling human aging .-Characterizing neural circuitry with programmed human neurons.- Direct conversion of fibroblasts to neuronal cells -- Human pluripotent stem cells as tools for modelling neurodegeneration.- From Rett syndrome to classical autism: modeling autism spectrum disorders using human neurons.- Testing evolutionary principles in a dish using embryonic stem cells: the example of the Huntington's Disease gene.- Using stem cells to discover therapeutic targets in ALS and SMA .- Using stem cells to understand and treat Alzheimer's disease.- Using pluripotent stem cells to decipher mechanisms and identify treatments for diseases that affect the brain.- Modeling neural development and disease in human pluripotent stem cells -- Subject index.
520 $aThe recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed the experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. In addition, because PSC technology allows for the study of human neurons during development, disease-specific pathways can be investigated prior to and during disease onset. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, it is now feasible to obtain gene expression profiles from neurons that capture the genetic uniqueness of each patient. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases.
650 20 $aNeurology.
650 20 $aStem cells.
650 20 $aNeurosciences.
650 0 $aMedicine.
650 0 $aNeurosciences.
650 0 $aNeurology.
650 0 $aStem cells.
650 14 $aBiomedicine.
700 1 $aChristen, Yves.
776 08 $iPrinted edition:$z9783642366475
830 0 $aResearch and Perspectives in Neurosciences ;$v20.
988 $a20130627
906 $0VEN