MARC Record from harvard_bibliographic_metadata

LEADER: 03623nam a22005175a 4500
001 013717805-0
005 20130816191756.0
008 130625s2013 gw | s ||0| 0|eng d
020 $a9783642375552
020 $a9783642375552
020 $a9783642375545
024 7 $a10.1007/978-3-642-37555-2$2doi
035 $a(Springer)9783642375552
040 $aSpringer
050 4 $aQH345
050 4 $aQD415-436
072 7 $aPSB$2bicssc
072 7 $aSCI007000$2bisacsh
082 04 $a572$223
100 1 $aRahman, Masoud.
245 10 $aProtein-Nanoparticle Interactions :$bThe Bio-Nano Interface /$cby Masoud Rahman, Sophie Laurent, Nancy Tawil, L'Hocine Yahia, Morteza Mahmoudi.
260 $aBerlin, Heidelberg :$bSpringer Berlin Heidelberg :$bImprint: Springer,$c2013.
300 $aX, 84 p. 24 illus., 20 illus. in color.$bdigital.
490 1 $aSpringer Series in Biophysics,$x0932-2353 ;$v15
505 0 $aThe Biological Significance of ‘Nano’ interactions -- Nanoparticle and Protein Corona -- Protein Corona: Applications and Challenges -- Analytical Methods for Corona Evaluations.
520 $aIn recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
650 20 $aNanotechnology.
650 10 $aLife sciences.
650 0 $aLife sciences.
650 0 $aToxicology.
650 0 $aBiochemistry.
650 0 $aRNA-ligand interactions.
650 0 $aNanotechnology.
650 24 $aBiochemistry, general.
650 24 $aProtein-Ligand Interactions.
650 24 $aPharmacology/Toxicology.
650 24 $aBiophysics and Biological Physics.
650 24 $aNanoscale Science and Technology.
700 1 $aLaurent, Sophie.
700 1 $aTawil, Nancy.
700 1 $aYahia, L'Hocine.
700 1 $aMahmoudi, Morteza.
776 08 $iPrinted edition:$z9783642375545
830 0 $aSpringer Series in Biophysics ;$v15.
988 $a20130702
906 $0VEN