MARC record from Internet Archive

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020 $a9781597454636$q(e-ISBN)
020 $a159745463X$q(e-ISBN)
020 $z9781934115237$q(alk. paper)
020 $z1934115231$q(alk. paper)
024 7 $a10.1007/978-1-59745-463-6$2doi
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050 4 $aR853.B54$bB565 2008
060 00 $a2008 E-309
060 10 $aQV 744$bB61515 2008
072 7 $aMMG$2bicssc
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245 00 $aBiomarker methods in drug discovery and development /$cedited by Feng Wang.
260 $aTotowa, NJ :$bHumana Press,$c℗♭2008.
300 $a1 online resource (xviii, 396 pages, 7 unnumbered pages of plates) :$billustrations.
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $atext file$bPDF$2rda
490 1 $aMethods in pharmacology and toxicology
504 $aIncludes bibliographical references and index.
588 0 $aPrint version record.
505 0 $aBiomarker sample collection and handling in the clinical setting to support early phase drug development -- Gene Expression-Based Biomarkers of Drug Safety -- Profiling Gene Expression Signatures Using Fluorescent Microspheres -- Real-Time PCR Gene Expression Assays in Biomarker Discovery and Validation -- SAGE Analysis in Identifying Phenotype SNPs -- SNP and DNA Methylation Analysis using Pyrosequencing Methods -- The Application of LCM for the Analysis of Specific Cell-Type Gene Expression in a Complex Tissue: the Primate Endometrium -- The use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery -- Difference In Gel Electrophoresis (DIGE), a high resolution protein biomarker research tool -- Label-free Mass Spectrometry-based Protein Quantification Technologies in Protein Biomarker Discovery -- Top-Down Quantitative Proteomic Analysis using a Highly Multiplexed Isobaric Mass Tagging Strategy -- SELDI Technology for Identification of Protein Biomarkers -- Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High Throughput Screens -- LC-MS Metabonomics Methodology in Biomarker Discovery -- GC/MS-based metabolomics -- NMR-Based Metabolomics for Biomarker Discovery -- Unraveling Glycerophospholipidomes by Lipidomics.
520 $aWithin the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research and development processes. As a volume in the Methods in Pharmacology and Toxicology™ series, this book offers user-friendly, step-by-step laboratory protocols for readily reproducible experiments. Comprehensive and state-of-the-art, Biomarker Methods in Drug Discovery and Development is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.
546 $aEnglish.
650 0 $aBiochemical markers.
650 0 $aDrug development.
650 7 $aBiochemical markers.$2fast$0(OCoLC)fst00831950
650 7 $aDrug development.$2fast$0(OCoLC)fst00898670
650 2 $aDrug Design.
650 2 $aBiomarkers, Pharmacological.
650 2 $aDrug Discovery.
650 2 $aBiomarkers.
650 2 $aChemistry, Pharmaceutical.
650 2 $aInvestigative Techniques.
650 2 $aBiological Factors.
650 2 $aChemistry.
650 2 $aAnalytical, Diagnostic and Therapeutic Techniques and Equipment.
650 2 $aChemicals and Drugs.
650 2 $aPharmacology.
650 2 $aNatural Science Disciplines.
650 2 $aBiological Science Disciplines.
650 2 $aDisciplines and Occupations.
650 7 $aMedical Research.$2hilcc
650 7 $aMedicine.$2hilcc
650 7 $aHealth & Biological Sciences.$2hilcc
650 14 $aPharmacology/Toxicology.$0http://scigraph.springernature.com/things/product-market-codes/B21007
650 24 $aHuman Genetics.$0http://scigraph.springernature.com/things/product-market-codes/B12008
650 24 $aCell Biology.$0http://scigraph.springernature.com/things/product-market-codes/L16008
650 24 $aMolecular Medicine.$0http://scigraph.springernature.com/things/product-market-codes/B1700X
655 4 $aElectronic books.
700 1 $aWang, Feng,$d1961 January 27-
776 08 $iPrint version:$tBiomarker methods in drug discovery and development.$dTotowa, NJ : Humana Press, ℗♭2008$z9781934115237$w(DLC) 2007943120$w(OCoLC)182528174
830 0 $aMethods in pharmacology and toxicology.
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856 40 $zAccess restricted to Harris Learning Library use, and to students, faculty, and staff of Nipissing University.$uhttp://books.eclibrary.ca/isbn/9781934115237
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