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020 $a331901580X$q(electronic bk.)
020 $z9783319015798$q(print)
020 $z3319015796
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037 $acom.springer.onix.9783319015804$bSpringer Nature
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100 1 $aDakubo, Gabriel D.,$eauthor.
245 10 $aCancer biomarkers in body fluids :$bprinciples /$cGabriel D. Dakubo.
264 1 $aSwitzerland :$bSpringer,$c2016.
300 $a1 online resource
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
504 $aIncludes bibliographical references.
588 0 $aOnline resource; title from PDF title page (SpringerLink, viewed September 14, 2016).
505 0 $aPreface; Contents; Chapter 1: Molecular Pathology of Cancer; Key Topics; 1.1 Introduction; 1.2 Functional Anatomy of the Cancer Cell; 1.3 History of Cancer Molecular Pathology; 1.4 Causes and Risk Factors of Cancer; 1.4.1 Infectious Causes of Cancer and Circulating Biomarkers; 1.5 The Biology of Cancer and Biomarkers; 1.6 Mutations as Cancer Biomarkers; 1.7 DNA Repair Mechanisms; 1.7.1 Direct Repair System; 1.7.2 Excision Repair; 1.7.2.1 Base-Excision Repair; 1.7.2.2 Nucleotide-Excision Repair; 1.7.2.3 Mismatch Repair; 1.7.3 Repair of Double-Strand Breaks.
505 8 $a1.8 Oncogene and Tumor Suppressor Gene Alterations as Biomarkers1.9 Cancer Signaling Pathway Alterations as Biomarkers; 1.9.1 The Receptor Tyrosine Kinase (RTK) Signaling Pathway; 1.9.2 The Phosphoinositide 3-Kinase (PI3K) Signaling Pathway; 1.9.3 The Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway; 1.9.4 The Mesenchymal-Epithelial Transition (MET) Factor Signaling Pathway; 1.9.5 The Janus Kinase (JAK) Signaling Pathway; 1.9.6 The Transforming Growth Factor-Beta (TGFbeta) Signaling Pathway; 1.9.7 The Nuclear Factor-kB (NF-kB) Signaling Pathway; 1.9.8 Src Signaling in Cancer Invasion.
505 8 $a1.9.9 Control of the Cell Cycle1.9.10 Hypoxia-Inducible Factor Signaling; 1.9.11 The WNT/beta-Catenin Signaling Pathway; 1.9.12 The Hedgehog Signaling Pathway; 1.9.13 The Notch Signaling Pathway; 1.10 Cell Death Processes and Cancer; 1.10.1 Nomenclature for Cell Death Processes; 1.10.2 Apoptosis; 1.10.3 Cancer Initiation as Defects in Apoptosis; 1.11 Multistep Carcinogenesis and Early Detection Cancer Biomarkers; 1.12 Personalized Cancer Care; 1.12.1 Nomenclature of Targeted Therapies; 1.12.2 Tests of Interest in Personalized Oncology; 1.13 Epigenetic Modifications and Cancer.
505 8 $a1.13.1 DNA Methylation1.13.2 Histone Modification; 1.13.3 The Cancer Cell Epigenome; 1.14 Genetic Alterations in Cancer; 1.14.1 Chromosomal Alterations; 1.14.1.1 Chromosomal Instability; 1.14.1.2 Microsatellite Alterations; 1.14.1.3 Gene Amplification; 1.14.1.4 Telomere Dysfunction; 1.14.2 Gene Mutations; 1.14.2.1 Cancer Genome Consortia; 1.15 The Cancer Cell Transcriptome; 1.16 The Proteome or Peptidome; 1.16.1 Serum Peptidome; 1.16.2 Serum vs. Plasma Proteomics; 1.16.3 Issues with Proteomic Biomarker Studies; 1.17 The Cancer Cell Metabolome; 1.17.1 Body Fluid Metabolomics; 1.18 Summary.
505 8 $aInternet ResourcesReferences; Chapter 2: Advanced Technologies for Body Fluid Biomarker Analyses; Key Topics; 2.1 Introduction; 2.2 High-Throughput Technologies for Biomarker Analyses; 2.3 Next-Generation Sequencing; 2.4 Single-Cell Analysis; 2.4.1 Whole Genome Amplification; 2.4.2 Whole Transcriptome Amplification; 2.4.3 Whole Genome Analysis of Circulating Tumor Cells; 2.5 Proteomic Technologies for Body Fluid Analysis; 2.6 Gel Based (2D and DIGE); 2.7 Non-gel-based Proteomic Techniques; 2.7.1 Mass Spectrometry; 2.7.1.1 Matrix-Assisted Laser Desorption/Ionization (MALDI)-MS.
520 $aThis work presents the details of cancer biomarkers deployed for noninvasive diagnosis in 18 separate body fluids, as well as assessing their potential in the field of personalized cancer therapeutics and the prospects for coordinated regulatory validation.
650 0 $aCancer$xMolecular diagnosis.
650 0 $aCancer$xGenetic aspects.
650 0 $aBiochemical markers.
650 2 $aNeoplasms$xdiagnosis
650 2 $aBiomarkers
650 6 $aCancer$xDiagnostic moléculaire.
650 6 $aCancer$xAspect génétique.
650 6 $aMarqueurs biologiques.
650 7 $aOncology.$2bicssc
650 7 $aMedical genetics.$2bicssc
650 7 $aHEALTH & FITNESS$xDiseases$xGeneral.$2bisacsh
650 7 $aMEDICAL$xClinical Medicine.$2bisacsh
650 7 $aMEDICAL$xDiseases.$2bisacsh
650 7 $aMEDICAL$xEvidence-Based Medicine.$2bisacsh
650 7 $aMEDICAL$xInternal Medicine.$2bisacsh
650 7 $aBiochemical markers.$2fast$0(OCoLC)fst00831950
650 7 $aCancer$xGenetic aspects.$2fast$0(OCoLC)fst00845368
650 7 $aCancer$xMolecular diagnosis.$2fast$0(OCoLC)fst00845398
655 4 $aElectronic books.
776 08 $iPrint version:$aDakubo, Gabriel D.$tCancer biomarkers in body fluids.$z3319015796$z9783319015798$w(OCoLC)855905454
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