MARC record from Internet Archive

LEADER: 07404cam 2200985Ia 4500
001 ocn187913601
003 OCoLC
005 20200525235743.0
008 080107s2007 nyuaf ob 001 0 eng d
006 m o d
007 cr cn|||||||||
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019 $a228377015$a320967122$a417540803$a436367904$a552020687$a648219785$a698454174
020 $a9781402054662
020 $a1402054661
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035 $a(OCoLC)187913601$z(OCoLC)228377015$z(OCoLC)320967122$z(OCoLC)417540803$z(OCoLC)436367904$z(OCoLC)552020687$z(OCoLC)648219785$z(OCoLC)698454174
037 $a978-1-4020-5465-5$bSpringer$nhttp://www.springerlink.com
050 4 $aQH599$b.C47 2007eb
060 4 $aW1$bSU14 v.41 2007
060 4 $aQU 56$bC5573 2007
070 $aQH599$b.C572 2007
072 7 $aQH$2lcco
072 7 $aQP$2lcco
072 7 $aSCI$x049000$2bisacsh
082 04 $a572.8/7$222
245 00 $aChromatin and disease /$cedited by Tapas K. Kundu and Dipak Dasgupta.
260 $aNew York, NY :$bSpringer,$c©2007.
300 $a1 online resource (xiii, 433 pages, 22 unnumbered pages of plates) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
490 1 $aSubcellular biochemistry,$x0306-0225 ;$vv. 41
504 $aIncludes bibliographical references and index.
588 0 $aPrint version record.
505 0 $aChromatin Structure, Dynamics and Disease -- Structural Organization of Dynamic Chromatin -- ATP-dependent Chromatin Remodelling -- Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1 -- Histone Variant Nucleosomes -- Histone Variants and Complexes Involved in Their Exchange -- Histone Chaperones in Chromatin Dynamics -- Functions Of The Histone Chaperone Nucleolin In Diseases -- Chromatin as a Target for the DNA-Binding Anticancer Drugs -- Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease -- Reversible Acetylation Of Non Histone Proteins -- MARs and MARBPs -- Epigenetic Modifications of Chromatin: Implication in disease and therapeutics -- Aberrant Forms of Histone Acetyltransferases in Human Disease -- Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases -- Functions of Myst Family Histone Acetyltransferases and Their Link to Disease -- Role Of Histone Phosphorylation In Chromatin Dynamics And Its Implications in Diseases -- Regulation And Function Of H3K9 Methylation -- Histone Acetylation And Methylation -- Chromatin-Associated Regulation Of Hiv-1 Transcription -- Small Molecule Modulators In Epigenetics.
520 $aIt is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics. In the light of these advances, it happens to be the right time to explore current insights into various aspect of chromatin and disease connection under one cover. Authors who are actively involved in chromatin research and have made several original contributions to develop latest paradigms in the field have written the chapters of this book. Significantly, the authors' repertoire is truly international. They come from eight different countries of Asia, Europe and America. The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling.
650 0 $aChromatin.
650 0 $aEpigenesis.
650 0 $aDrug targeting.
650 0 $aHuman genome.
650 12 $aChromatin$xpathology.
650 22 $aChromatin$xphysiology.
650 22 $aEpigenesis, Genetic.
650 22 $aHistones$xphysiology.
650 22 $aHistones$xtherapeutic use.
650 7 $aSCIENCE$xLife Sciences$xMolecular Biology.$2bisacsh
650 7 $aBiomédecine.$2eclas
650 7 $aSciences de la vie.$2eclas
650 7 $aChromatin.$2fast$0(OCoLC)fst00859922
650 7 $aDrug targeting.$2fast$0(OCoLC)fst00898709
650 7 $aEpigenesis.$2fast$0(OCoLC)fst00914128
650 7 $aHuman genome.$2fast$0(OCoLC)fst00963101
655 4 $aElectronic books.
700 1 $aKundu, Tapas K.
700 1 $aDasgupta, Dipak.
776 08 $iPrint version:$tChromatin and disease.$dNew York, NY : Springer, ©2007$z9781402054655$z1402054653$w(OCoLC)86075161
830 0 $aSub-cellular biochemistry ;$vv. 41.
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856 40 $3SpringerLink$uhttps://link.springer.com/book/10.1007/978-1-4020-5465-5
856 40 $3SpringerLink$uhttp://www.library.yorku.ca/eresolver/?id=1237858$zAn electronic book accessible through the World Wide Web; click for information
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