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024 7 $a10.1007/978-3-540-71547-4$2doi
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037 $a978-3-540-71546-7$bSpringer$nhttp://www.springerlink.com
050 4 $aQD1$b.F58eb vol. 277
060 4 $aW1$bTO539LK v.277 2007
060 4 $aQT 36$bC912 2007
072 7 $aQD$2lcco
072 7 $aPNN.$2bicssc
072 7 $aSCI013040.$2bisacsh
082 04 $a681/.2$222
084 $aTP212. 2$2clc
245 00 $aCreative chemical sensor systems /$cvolume editor, Thomas Schrader ; with contributions by E.V. Anslyn [and others].
260 $aBerlin ;$aNew York :$bSpringer,$c©2007.
300 $a1 online resource (xii, 303 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $atext file$bPDF$2rda
490 1 $aTopics in current chemistry,$x0340-1022 ;$v277
504 $aIncludes bibliographical references and indexes.
505 0 $aThe development of artificial receptors for small peptides using combinatorial approaches / C. Schmuck, P. Wich -- Calix[n]arenes as protein sensors / A.W. Coleman [and others] -- Polypeptide conjugate binders for protein recognition / L. Baltzer -- Saccharide-selective boronic acid based photoinduced electron transfer (PET) fluorescent sensors / T.D. James -- Biomolecular sesning with colorimetric vesicles / R. Jelinek, S. Kolusheva -- Combining molecular recognition, optical detection, and chemometric analysis / B.E. Collins, A.T. Wright, E.V. Anslyn -- Analyte sensing across membranes with artificial pores / S. Matile, H. Tanaka, S. Litvinchuk -- Identification of catalysts in combinatorial libraries / J.D. Revell, H. Wennemers -- Dynamic combinatorial libraries for the development of synthetic receptors and sensors / S. Otto, K. Severin.
588 0 $aPrint version record.
520 $aSince several excellent books have appeared on the issue of chemical and biochemical sensing, this compendium concentrates on recent creative new approaches using chemical means for the detection and quanti?cation of - portant analytes. These are presented either from a technical viewpoint or fromtheperspectiveofselectivemolecularrecognitionwitharti?cialreceptor molecules. Consequently, the entire book is subdivided into two categories, i. e., natural targetsand detection techniques. In the?rst part, the challenging task of sensing peptides and proteins as wellassaccharidesisaddressedfromseveralperspectives:Smalllibrarieswith maximum diversity are ef?ciently used to reach high af?nity and selectivity of arti?cial hosts for short peptide sequences. Preorganized aromatic vessels are tailored for certain protein epitopes and shown to selectively address the prion protein, and a new conjugation technique operating at physiological conditions on helix-loop-helix motifs, leads to protein binders of exquisite af?nity. Finally, elegant sensor systems for multifunctional carbohydrates in their naturalform, whichuse theprinciple ofphoto-induced electrontransfer for?uorescence detection, are presented. The second part of this book is devoted to creative detection techniques employing chemical processes: Liposomes with integral self-assembled - acetylene lipid areas show an intense blue color, which gradually changes to red if biological analytes of various sizes speci?cally interact with emb- ded hosts. Principal component analysis and arti?cial neuronal networks are novel methods to quantitatively analyze complex mixtures. An alternative - proach uses arti?cial peptidic pores, which are able to release self-quenched?uorophoresthataresubstitutedbytighterbindinganalytes.
650 0 $aChemical detectors.
650 0 $aCell receptors.
650 12 $aBiosensing Techniques$xmethods.
650 22 $aMicrochemistry.
650 22 $aMolecular Structure.
650 22 $aReceptors, Cell Surface$xphysiology.
650 07 $aMicrochemistry.$2cct
650 07 $aMolecular structure.$2cct
650 07 $aReceptors, Cell Surface$xphysiology.$2cct
650 07 $aChemical detectors.$2cct
650 07 $aCell receptors.$2cct
650 07 $aBiosensing Techniques$xmethods.$2cct
650 7 $aScience des matériaux.$2eclas
650 7 $aChimie.$2eclas
650 7 $aCell receptors.$2fast$0(OCoLC)fst00850227
650 7 $aChemical detectors.$2fast$0(OCoLC)fst00852873
653 00 $achemie
653 00 $achemistry
653 00 $abiochemie
653 00 $abiochemistry
653 00 $ageneeskunde
653 00 $amedicine
653 00 $afysische chemie
653 00 $aphysical chemistry
653 00 $aanalytische scheikunde
653 00 $aanalytical chemistry
653 00 $aorganische scheikunde
653 00 $aorganic chemistry
653 10 $aChemistry (General)
653 10 $aChemie (algemeen)
655 4 $aElectronic books.
700 1 $aSchrader, Thomas.
700 1 $aAnslyn, Eric V.,$d1960-
773 0 $tSpringer e-books
776 08 $iPrint version:$tCreative chemical sensor systems.$dBerlin ; New York : Springer, ©2007$z9783540715467$z3540715460$w(OCoLC)145453536
830 0 $aTopics in current chemistry ;$v277.$x0340-1022
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