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100 1 $aAmaratunga, Dhammika,$d1956-
245 10 $aExploration and analysis of DNA microarray and protein array data /$cDhammika Amaratunga, Javier Cabrera.
260 $aHoboken, NJ :$bJohn Wiley,$c©2004.
300 $axiv, 246 pages :$billustrations ;$c24 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
490 1 $aWiley series in probability and statistics.
504 $aIncludes bibliographical references (pages 222-236) and indexes.
505 00 $tA Note on Exploratory Data Analysis --$tComputing Considerations and Software --$tGenomics Basics --$tGenes --$tDNA --$tGene Expression --$tHybridization Assays and Other Laboratory Techniques --$tThe Human Genome --$tGenome Variations and Their Consequences --$tThe Role of Genomics in Pharmaceutical Research --$tProteins --$tBioinformatics --$tMicroarrays --$tTypes of Microarray Experiments --$tExperiment Type 1: Tissue-Specific Gene Expression --$tExperiment Type 2: Development Genetics --$tExperiment Type 3: Genetic Diseases --$tExperiment Type 4: Complex Diseases --$tExperiment Type 5: Pharmacological Agents --$tExperiment Type 6: Plant Breeding --$tExperiment Type 7: Environmental Monitoring --$tA Very Simple Hypothetical Microarray Experiment --$tA Typical Microarray Experiment --$tMicroarray Preparation --$tSample Preparation --$tThe Hybridization Step --$tScanning the Microarray --$tInterpreting the Scanned Image --$tMultichannel cDNA Microarrays --$tOligonucleotide Arrays --$tBead-Based Arrays --$tConfirmation of Microarray Results --$tProcessing the Scanned Image --$tConverting the Scanned Image to the Spotted Image --$tGridding --$tSegmentation --$tQuantification --$tQuality Assessment --$tVisualizing the Spotted Image --$tNumerical Evaluation of Array Quality --$tSpatial Problems --$tSpatial Randomness --$tQuality Control of Arrays --$tAssessment of Spot Quality --$tAdjusting for Background --$tAdjusting for the Estimated Background --$tExpression Level Calculation for Two-Channel cDNA Microarrays --$tExpression Level Calculation for Oligonucleotide Arrays.
520 $aThe emergence of genomics, the study of genes, is one of the major scientific revolutions of this century. Microarrays, a method used to analyze numerous DNA samples rapidly, enables scientists to make sense of this mountain of data using statistical analysis. They are being used in such areas of biomedical research as studying patterns for gene activity that cause cancers to spread. This book presents a comprehensive methodology for analyzing DNA microarray and protein array data. The most comprehensive treatment of this important emerging field, Exploration and Analysis of DNA Microarray and Protein Array Data includes: A review of basic molecular biology and a chapter introducing microarrays and their preparation Chapters on processing scanned images, preprocessing microarray data, group comparative experiments, and other designs Discussions of clustering, protein arrays, and applications for diagnostic tools Ample exercises assist absorption.
650 0 $aDNA microarrays$xStatistical methods.
650 0 $aProtein microarrays$xStatistical methods.
650 7 $aDNA microarrays$xStatistical methods.$2fast$0(OCoLC)fst00886594
650 17 $aDNA Microarrays.$2gtt
650 7 $aBiologia molecular.$2larpcal
650 7 $aDna (métodos estatísticos)$2larpcal
650 12 $aOligonucleotide Array Sequence Analysis$xstatistics & numerical data.
650 22 $aProtein Array Analysis$xstatistics & numerical data.
700 1 $aCabrera, Javier.
830 0 $aWiley series in probability and statistics.
856 41 $3Table of contents$uhttp://catdir.loc.gov/catdir/toc/wiley032/2003050097.html
856 41 $3Table of contents$uhttp://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010317120&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
856 41 $zWiley Online Library$uhttps://doi.org/10.1002/9780470317129$xeLoaderURL$xwl4$xwlocn264621192$zAvailable to Stanford-affiliated users at:
856 42 $3Contributor biographical information$uhttp://catdir.loc.gov/catdir/bios/wiley045/2003050097.html
856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/description/wiley038/2003050097.html
856 4 $3Cover$uhttp://swbplus.bsz-bw.de/bsz105996351cov.htm$v20090323062725
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