MARC record from Internet Archive

LEADER: 06858cam 2200841Mi 4500
001 on1000116542
003 OCoLC
005 20200803002043.0
008 170810s2017 sz ob 000 0 eng d
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020 $a9783319609072$q(electronic bk.)
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020 $z9783319609065
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024 7 $a10.1007/978-3-319-60907-2$2doi
035 $a(OCoLC)1000116542$z(OCoLC)1004992843$z(OCoLC)1005109797$z(OCoLC)1011793961$z(OCoLC)1048165142$z(OCoLC)1066476734$z(OCoLC)1112877644
037 $acom.springer.onix.9783319609072$bSpringer Nature
050 4 $aQH603.E93
072 7 $aSCI$x007000$2bisacsh
072 7 $aMJCL$2bicssc
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245 00 $aExtracellular matrix in tumor biology /$cRolf A. Brekken, Dwayne Stupack, editors.
260 $aCham :$bSpringer,$c2017.
300 $a1 online resource
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
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490 1 $aBiology of extracellular matrix,$x0887-3224
505 0 $aPreface; Contents; Chapter 1: The Extracellular Matrix of Tumors: A Focus on Fibronectin and Fibulin-5; 1.1 The Function and Composition of the Extracellular Matrix; 1.2 The Role of the ECM in Tumor Development with Emphasis on FN; 1.3 Matricellular Proteins: Extracellular Modulators of the ECM; 1.4 Fibulin-5; 1.4.1 Fbln5 in Cell Adhesion/Migration; 1.4.2 Fbln5 in Proliferation/Survival; 1.4.3 Fbln5 in Angiogenesis; 1.4.4 Fbln5 in Tumor Progression; 1.5 Conclusion; References; Chapter 2: Internalization of Collagen: An Important Matrix Turnover Pathway in Cancer.
505 8 $a2.1 Collagen Degradation in Cancer2.2 Extracellular Collagen Degradation; 2.3 Intracellular Collagen Degradation; 2.3.1 The Collagen Internalization Receptor uPARAP/Endo180; 2.3.2 The Collagen Internalization Receptor MR; 2.4 Intracellular Collagen Degradation In Vivo; 2.4.1 Imaging Collagen Internalization In Vivo; 2.4.2 Intracellular Collagen Degradation in Cancer; References; Chapter 3: Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression; 3.1 Structure, Function, and Regulation of Lumican; 3.2 Lumican Implications in Cancer; 3.2.1 Breast Cancer.
505 8 $a3.2.2 Colorectal Cancer3.2.3 Lung Cancer; 3.2.4 Pancreatic Cancer; 3.3 Drug Delivery in Cancer and Its Association with Lumican Expression; 3.3.1 Collagen Organization in Tumors; 3.3.2 VEGF and PDGF; 3.4 Summary; References; Chapter 4: Versican: Role in Cancer Tumorigenesis; 4.1 Introduction; 4.2 Source of Versican in Cancer; 4.3 The Role of Versican in Cancer; 4.4 The Regulation of Versican Expression in Cancer; 4.5 Versican as a Diagnostic and Prognostic Marker in Cancer; 4.6 Versican in LMS: Our Experience; 4.7 Conclusions; References.
505 8 $aChapter 5: Engineering Advanced Models of the Glioblastoma Microenvironment Using Biomaterials5.1 Introduction; 5.2 The Role of the Microenvironment in GBM Malignancy; 5.2.1 ECM; 5.3 Engineering Advanced Models of the GBM Microenvironment; 5.3.1 Traditional Culture Systems; 5.3.2 Polymer-Based 3D Matrices; 5.3.3 Microfabricated Platforms; 5.3.4 Molecular Discovery and Screening; 5.4 Future Directions; 5.5 Conclusions; References; Chapter 6: Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way; 6.1 Introduction; 6.2 Breaching the BM De Novo: AC Invasion.
505 8 $a6.2.1 Transcription Factors Promoting Invasion6.2.2 Establishing the Invasive Cell Membrane; 6.2.3 AC Invadopodia and the Invasive Protrusion: Breaching and Clearing the BM; 6.3 Post AC Invasion: BM Sliding Further Opens the Breach; 6.4 AC Invasion and SPARC: A Model for the Tumor Microenvironment; 6.5 Summary and Perspective; References.
588 0 $aPrint version record.
520 $aThis volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.
504 $aIncludes bibliographical references at the end of each chapters.
650 0 $aExtracellular matrix.
650 0 $aTumors.
650 12 $aNeoplastic Processes.
650 22 $aExtracellular Matrix.
650 7 $aSCIENCE$xLife Sciences$xBiochemistry.$2bisacsh
650 7 $aExtracellular matrix.$2fast$0(OCoLC)fst00918995
650 7 $aTumors.$2fast$0(OCoLC)fst01158759
655 4 $aElectronic books.
700 1 $aBrekken, Rolf A.
700 1 $aStupack, Dwayne.
776 08 $iPrint version:$z3319609068$z9783319609065$w(OCoLC)988276122
830 0 $aBiology of extracellular matrix.
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