MARC record from Internet Archive

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003 OCoLC
005 20200515115752.0
008 970521s1997 maua b 001 0 eng
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050 00 $aQR185.6$b.P63 1997
060 00 $a1998 D-279
060 10 $aQW 575$bP742g 1997
082 00 $a616.07/95$221
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100 1 $aPodolsky, Scott H.
245 14 $aThe generation of diversity :$bclonal selection theory and the rise of molecular immunology /$cScott H. Podolsky, Alfred I. Tauber.
260 $aCambridge, Mass. :$bHarvard University Press,$c1997.
300 $ax, 508 pages :$billustrations ;$c25 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
504 $aIncludes bibliographical references (pages 439-492) and index.
505 0 $aIntroduction -- Prelude: A conceptual orientation -- The Burnet legacy -- CST and molecular immunology: a dogmatic alliance -- Interlude: The conventional history -- Germline, somatic mutation, and recombinatorial models: 1960-1974 -- Immunobiological theories of antibody diversity -- From protein to DNA -- The recombinant revolution -- Interlude: A historiographic reappraisal -- Heavy chain diversity and the molecular finale -- An accounting -- The fate of the immune self.
520 $aA major problem for immunologists had long been to determine how cells of the immune system could produce millions of distinct antibodies - and produce them on demand. The clonal selection theory explains that cells with genetic instructions to produce each antibody exist in the body in small numbers until exposure to the right molecule - the antigen - triggers the selective cloning that will reproduce the required cells. But how can so many different antibody-producing cells be generated from such limited genetic material? The solution to this question came from new applications of molecular biology, and, as the authors argue, the impact of the new techniques changed both the methods and the concepts of immunology.
520 8 $aThe Generation of Diversity is an intellectual history of the major theoretical problem in immunology and its resolution in the post-World War II period. It will provide for immunologists essential background for understanding the conceptual conflicts occurring in the field today.
650 0 $aMolecular immunology$xHistory.
650 0 $aClonal selection theory$xHistory.
650 0 $aAntibody diversity$xHistory.
650 12 $aAntibody Diversity$xphysiology.
650 22 $aImmunity, Cellular.
650 22 $aMolecular Biology.
650 6 $aImmunologie moléculaire.
650 6 $aSélection clonale, Théorie de la.
650 7 $aAntibody diversity.$2fast$0(OCoLC)fst00810450
650 7 $aClonal selection theory.$2fast$0(OCoLC)fst00864570
650 7 $aMolecular immunology.$2fast$0(OCoLC)fst01024811
650 17 $aImmunologie.$2gtt
650 17 $aMoleculaire biologie.$2gtt
650 07 $aImmunologische Erkennung.$2swd
650 07 $aForschung.$2swd
650 07 $aGeschichte 1940-1996.$2swd
650 07 $aImmunreaktion.$2swd
655 7 $aHistory.$2fast$0(OCoLC)fst01411628
700 1 $aTauber, Alfred I.
776 08 $iOnline version:$aPodolsky, Scott H.$tGeneration of diversity.$dCambridge, Mass. : Harvard University Press, 1997$w(OCoLC)606948257
776 08 $iOnline version:$aPodolsky, Scott H.$tGeneration of diversity.$dCambridge, Mass. : Harvard University Press, 1997$w(OCoLC)629921340
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948 $hNO HOLDINGS IN P4A - 241 OTHER HOLDINGS