MARC record from Internet Archive

LEADER: 06824cam 2201309 a 4500
001 ocm26505726
003 OCoLC
005 20200511220259.0
008 920911s1993 enka b 001 0 eng
010 $a 92049275
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020 $a9780521334211$q(hc)
020 $a0521336600
020 $a9780521336604
035 $a(OCoLC)26505726$z(OCoLC)27975992$z(OCoLC)28799963$z(OCoLC)35569182$z(OCoLC)38200578$z(OCoLC)123058884
050 00 $aRB155$b.W35 1993
060 00 $aQZ 50$bW431g 1993
082 00 $a573.2/1$220
084 $a42.21$2bcl
084 $a44.48$2bcl
084 $aWG 7200$2rvk
084 $aQZ 50$2sdnb
100 1 $aWeiss, Kenneth M.
245 10 $aGenetic variation and human disease :$bprinciples and evolutionary approaches /$cKenneth M. Weiss.
260 $aCambridge ;$aNew York :$bCambridge University Press,$c1993.
300 $axxiv, 354 pages :$billustrations ;$c24 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
490 1 $aCambridge studies in biological anthropology
504 $aIncludes bibliographical references (pages 315-343) and index.
520 $aRecent developments in molecular and statistical methods have made it possible to identify the genetic basis of any biological trait and have given rise to spectacular advances in the study of human disease. The book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. The methods for segregation analysis and linkage mapping in human family data are reviewed, and related to standard epidemiological measures of causation and association. In addition, the effects of environmental risk factors are discussed in the context of causal statistical models. Special samples and strategies for identifying genetic variation associated with disease are also examined, and explored from an evolutionary perspective. This book will appeal to a wide range of biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.
505 0 $apt. I. Genes and their expression. 1. What is a gene? 2. The logic of the genome. 3. Concepts of frequency and association in populations. 4. Genes and phenotypes in populations -- pt. II. Introduction to genetic epidemiology: inference from observational data. 5. Segregation analysis: discrete traits in families. 6. Segregation analysis: quantitative traits in families. 7. Linkage analysis: finding and mapping genes for qualitative traits. 8. Linkage analysis: finding and mapping genes for quantitative traits -- pt. III. Evolution: Time Dimensions in Populations. 9. Genes over time and space. 10. Reconstructing history: the footprints of evolution. 11. Evolution generates heterogeneity -- pt. IV. Modification of the inherited genotype: the time dimension in individuals.
505 8 $a12. Phenotype amplification by the environment. 13. Infectious disease: the response to biological challenge. 14. Variation within the inherited genotype. 15. Cancer and aging: a microcosm of evolution during life -- Afterwords: towards a unified general model.
650 0 $aMedical genetics.
650 0 $aHuman genetics.
650 0 $aGenetic epidemiology.
650 2 $aBiological Evolution.
650 2 $aGenetic Variation.
650 2 $aGenetics.
650 2 $aGenetics, Medical.
650 6 $aGe ne tique me dicale.
650 6 $aGe ne tique humaine.
650 6 $aE pide miologie ge ne tique.
650 7 $a44.48 medical genetics.$0(NL-LeOCL)07761304X$2bcl
650 7 $aGenetic epidemiology.$2fast$0(OCoLC)fst00940068
650 7 $aHuman genetics.$2fast$0(OCoLC)fst00963075
650 7 $aMedical genetics.$2fast$0(OCoLC)fst01014133
650 7 $aE volution.$2fmesh
650 7 $aGe ne tique.$2fmesh
650 7 $aGe ne tique me dicale.$2fmesh
650 7 $aDiversite ge ne tique.$2fmesh
650 7 $aErbkrankheit$2gnd
650 7 $aHumangenetik$2gnd
650 17 $aZiekten.$2gtt
650 17 $aGenetische variatie.$2gtt
650 17 $aMedische genetica.$2gtt
650 17 $aEvolutie.$2gtt
650 7 $aGe ne tique me dicale.$2ram
650 7 $aGe ne tique humaine.$2ram
650 7 $aE pide miologie ge ne tique.$2ram
650 7 $aVariabilite .$2ram
653 0 $aHumans$aGenetics
653 00 $aepidemics
653 00 $aepidemiologie
653 00 $aepidemiology
653 00 $aevolutie
653 00 $aevolution
653 00 $agenetische stoornissen
653 00 $agenetic disorders
653 00 $agenetische variatie
653 00 $agenetic variation
653 00 $agenetica
653 00 $agenetics
653 00 $aerfelijke ziekten
653 00 $ahereditary diseases
653 00 $aovererving
653 00 $ainheritance
653 00 $aoorsprong
653 00 $aorigin
653 00 $afylogenetica
653 00 $aphylogenetics
653 00 $afylogenie
653 00 $aphylogeny
653 10 $aHuman Pathology
653 20 $aGenetics (General)
653 10 $aHumane pathologie
653 20 $aGenetica (algemeen)
830 0 $aCambridge studies in biological anthropology.
856 41 $3Table of contents$uhttp://catdir.loc.gov/catdir/toc/cam032/92049275.html
856 41 $3Table of contents$uhttp://www.gbv.de/dms/bowker/toc/9780521334211.pdf
856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/description/cam032/92049275.html
938 $aBaker & Taylor$bBKTY$c69.95$d69.95$i0521334217$n0002201432$sactive
938 $aBaker & Taylor$bBKTY$c50.00$d50.00$i0521336600$n0002589427$sactive
938 $aBaker and Taylor$bBTCP$n92049275
938 $aYBP Library Services$bYANK$n458152
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948 $hHELD BY P4A - 402 OTHER HOLDINGS