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LEADER: 05523cam 22007934a 4500
001 ocm49895248
003 OCoLC
005 20200504024235.0
008 020523s2003 enkaf b 001 0 eng
010 $a 2002025834
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020 $a0195135768$q(alk. paper)
020 $a9780195135763$q(alk. paper)
035 $a(OCoLC)49895248$z(OCoLC)51107412$z(OCoLC)52194382$z(OCoLC)492393144
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050 00 $aRC268.2$b.H676 2003
060 00 $a2003 E-949
060 10 $aQZ 202$bH812 2003
082 00 $a616.99/4071$221
084 $a44.81$2bcl
084 $a44.48$2bcl
084 $aXH 5319$2rvk
245 00 $aHormones, genes, and cancer /$c[edited by] Brian E. Henderson, Bruce Ponder, Ronald K. Ross.
260 $aOxford ;$aNew York :$bOxford University Press,$c2003.
300 $axiii, 450 pages, 4 unnumbered pages of plates :$billustrations (some color) ;$c26 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
504 $aIncludes bibliographical references and index.
505 0 $aIntroduction and background -- Biosynthesis, transport, and metabolism of steroid hormones -- The nuclear receptor superfamily -- Genomic approaches to the genetics of hormone-responsive cancer -- Breast cancer: epidemiology and molecular endocrinology -- The impact of exogenous hormone use on breast cancer risk -- An overview of genetic predisposition and the search for predisposing genes for breast cancer -- Estrogen biosynthesis genes: P-450 aromatase -- Estrogen metabolism genes: HSD17B1 and HSD17B2 -- Breast cancer: intervention in BRCA1 and BRCA2 families -- Implications of hormones and hormonal risk factors on screening strategies -- Hormonal chemoprevention with tamoxifen and selective estrogen receptor modulators -- Other hormonal prevention strategies -- Progression from hormone-dependent to hormone-independent breast cancer -- Prostate cancer: epidemiology and molecular endocrinology -- Androgen receptor signaling in prostate cancer -- Hereditary prostate cancer: the search for major genes and the role of genes involved in androgen action -- Androgen-independent prostate cancer progression: mechanistic insights -- Hormonal therapies for prostate cancer -- Endometrial cancer: epidemiology and molecular endocrinology -- Ovarian cancer: epidemiology and molecular endocrinology -- Testicular cancer: epidemiology and molecular endocrinology.
520 0 $aHormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.
650 0 $aCancer$xEndocrine aspects.
650 0 $aHormones$xCarcinogenicity.
650 0 $aGenerative organs$xCancer$xMolecular aspects.
650 0 $aGenerative organs$xCancer$xChemoprevention.
650 12 $aNeoplasms$xetiology.
650 22 $aHormones$xphysiology.
650 22 $aGenes$xphysiology.
650 7 $aCancer$xEndocrine aspects.$2fast$0(OCoLC)fst00845354
650 7 $aGenerative organs$xCancer$xChemoprevention.$2fast$0(OCoLC)fst01767297
650 7 $aGenerative organs$xCancer$xMolecular aspects.$2fast$0(OCoLC)fst01767299
650 7 $aHormones$xCarcinogenicity.$2fast$0(OCoLC)fst01767676
650 17 $aMaligne tumoren.$2gtt
650 17 $aImmunologie.$2gtt
650 17 $aAanleg.$2gtt
650 17 $aTherapiee n.$2gtt
650 07 $aCarcinogenese.$2swd
650 07 $aHormon.$2swd
700 1 $aHenderson, Brian E.
700 1 $aPonder, B. A. J.$q(Bruce A. J.),$d1944-
700 1 $aRoss, Ronald K.$q(Ronald Keith)
856 41 $3Table of contents$uhttp://catdir.loc.gov/catdir/enhancements/fy0613/2002025834-t.html
856 41 $3Table of contents$uhttp://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009890473&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/enhancements/fy0613/2002025834-d.html
938 $aBaker & Taylor$bBKTY$c95.00$d95.00$i0195135768$n0003660731$sactive
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948 $hNO HOLDINGS IN P4A - 158 OTHER HOLDINGS