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024 7 $a10.1007/978-1-59259-130-5$2doi
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100 1 $aLiebler, Daniel C.
245 10 $aIntroduction to proteomics :$btools for the new biology /$cby Daniel C. Liebler ; foreword by John R. Yates, III.
260 $aTotowa, NJ :$bHumana Press,$c©2002.
300 $a1 online resource (ix, 198 pages) :$billustrations (some color)
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504 $aIncludes bibliographical references and index.
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520 $aAdvances in genome sequencing, analytical instrumentation, and computing power have excitingly transformed the practice of biology by now making it possible to understand complex biological systems as collections of proteins-proteomes. In Introduction to Proteomics: Tools for the New Biology, Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein-protein interactions and networks. Comprehensive, concise, and easy-to-read, Introduction to Proteomics: Tools for the New Biology provides researchers new to proteomics with all the essential concepts and background needed to use the powerful new proteomic techniques in their research, to make intelligent requests to proteomics service facilities, and to better understand and utilize the rapidly growing proteomics literature.
533 $aElectronic reproduction.$b[Place of publication not identified] :$cHathiTrust Digital Library,$d2010.$5MiAaHDL
538 $aMaster and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.$uhttp://purl.oclc.org/DLF/benchrepro0212$5MiAaHDL
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588 0 $aPrint version record.
505 0 $aI. Proteomics and the Proteome -- 1. Proteomics and the New Biology -- 2. The Proteome -- II. Tools of Proteomics -- 3. Overview of Analytical Proteomics -- 4. Analytical Protein and Peptide Separations -- 5. Protein Digestion Techniques -- 6. Mass Spectrometers for Protein and Peptide Analysis -- 7. Protein Identification by Peptide Mass Fingerprinting -- 8. Peptide Sequence Analysis by Tandem Mass Spectrometry -- 9. Protein Identification with Tandem Mass Spectrometry Data -- 10. SALSA: An Algorithm for Mining Specific Features of Tandem MS Data -- III. Applications of Proteomics -- 11. Mining Proteomes -- 12. Protein Expression Profiling -- 13. Identifying Protein-Protein Interactions and Protein Complexes -- 14. Mapping Protein Modifications -- 15. New Directions in Proteomics.
650 0 $aProteomics.
650 2 $aProteome$xgenetics.
650 2 $aGenome.
650 2 $aProtein Conformation.
650 2 $aProteome$xanalysis.
650 2 $aSequence Analysis$xmethods.
650 6 $aProtéomique.
650 6 $aProtéines$xRecherche$xMéthodologie.
650 7 $aSCIENCE$xLife Sciences$xBiochemistry.$2bisacsh
650 7 $aProteomics.$2fast$0(OCoLC)fst01079785
650 7 $aAminosäurensequenz$2gnd
650 7 $aSequenzanalyse$gChemie$2gnd
650 7 $aLabortechnik$2gnd
650 7 $aProteomanalyse$2gnd
650 7 $aProteine$2gnd
650 7 $aConformação protéica.$2larpcal
650 7 $aProtéines$xRecherche$xMéthodologie.$2ram
655 4 $aElectronic books.
776 08 $iPrint version:$aLiebler, Daniel C.$tIntroduction to proteomics.$dTotowa, NJ : Humana Press, ©2002$z0585418799$w(DLC) 2001051465$w(OCoLC)48046062
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