MARC record from Internet Archive

LEADER: 08072cam 2200949 a 4500
001 ocn745003836
003 OCoLC
005 20221126141325.0
008 110804s2011 ne a ob 000 0 eng d
006 m o d
007 cr cn|||||||||
040 $aGW5XE$beng$epn$cGW5XE$dOCLCQ$dOCLCA$dQE2$dE7B$dEBLCP$dYDXCP$dUKMGB$dOCLCQ$dOCLCO$dMEAUC$dOCLCF$dOCLCA$dOCLCQ$dCOO$dDEBSZ$dOCLCQ$dVT2$dMERER$dOCLCO$dZ5A$dESU$dOCLCQ$dIOG$dOCLCA$dCEF$dU3W$dAU@$dWYU$dLHU$dYOU$dOCLCQ$dCNTRU$dOCLCO$dUKAHL$dOCLCQ$dW2U$dU@J$dERF$dOCLCQ$dOCLCA$dOCLCQ$dAJS$dOCLCQ$dOCLCO$dDCT$dOCLCQ$dOCLCO
016 7 $a015772589$2Uk
019 $a742286284$a742516437$a771421782$a771421783$a985060391$a1005814210$a1044252603$a1056446738$a1060883589$a1063889141$a1067191839$a1087312972$a1105726891$a1112585940$a1132924284$a1148110417$a1162775509$a1204015964
020 $a9789400714694$q(electronic bk.)
020 $a9400714696$q(electronic bk.)
020 $a9400714688$q(print)
020 $a9789400714687$q(print)
020 $z9789400714687
024 7 $a10.1007/978-94-007-1469-4$2doi
035 $a(OCoLC)745003836$z(OCoLC)742286284$z(OCoLC)742516437$z(OCoLC)771421782$z(OCoLC)771421783$z(OCoLC)985060391$z(OCoLC)1005814210$z(OCoLC)1044252603$z(OCoLC)1056446738$z(OCoLC)1060883589$z(OCoLC)1063889141$z(OCoLC)1067191839$z(OCoLC)1087312972$z(OCoLC)1105726891$z(OCoLC)1112585940$z(OCoLC)1132924284$z(OCoLC)1148110417$z(OCoLC)1162775509$z(OCoLC)1204015964
037 $a978-94-007-1468-7$bSpringer$nhttp://www.springerlink.com
050 4 $aQR185.8.M35$bR53 2011
060 4 $a2013 D-686
060 4 $aQZ 202
072 7 $aMJCL$2bicssc
072 7 $aMED062000$2bisacsh
082 04 $a611/.01826$223
100 1 $aRibatti, Domenico,$d1956-
245 10 $aMast cells and tumours :$bfrom biology to clinic /$cDomenico Ribatti, Enrico Crivellato.
260 $aDordrecht ;$aNew York :$bSpringer,$c©2011.
300 $a1 online resource (viii, 142 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $atext file
347 $bPDF
504 $aIncludes bibliographical references.
588 0 $aPrint version record.
520 $aMast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.
505 0 $aIntroduction -- 1. The mast cell -- 1.1. A historical overview -- 1.2. Biology of mast cells -- 2. Mast cell mediators -- 2.1. Granule composition -- 2.2. Histamine and serotonin -- 2.3. Proteases -- 2.4. Lipid mediators -- 2.5. Cytokines and growth factors -- 2.6. Chemokines -- 3. The tumour cell -- 3.1. Biology of tumour cell -- 3.2. The importance of microenvironment in tumor metastasis -- 3.3. The "seed and soil" theory -- 4. Tumour angiogenesis -- 4.1. The angiogenic switch -- 4.2. Phenotypic and genotypic characteristics of tumor vessels and genetic evidence that tumours are angiogenesis-dependent -- 4.3. What is the evidence that genetic instability promotes the angiogenic switch? -- 4.4. Hypoxic regulation of tumour angiogenesis -- 4.5. The role of pericytes in tumour angiogenesis -- 4.6. The role of inflammatory cells in tumour angiogenesis -- 4.7. Participation of hematopoietic cells and endothelial precursor cells to tumour angiogenesis -- 4.8. Alternative mechanisms of tumour angiogenesis -- 4.9. Vascular cooption -- 4.10. The prognostic significance of tumour angiogenesis -- 4.11. Angiogenesis is not necessarily involved in tumour progression -- 5. Mast cells and tumours -- 5.1. Mast cells and tumour growth in humans: pro and contra -- 6. Mast cells and tumour angiogenesis -- 6.1. Mast cell-induced angiogenesis studied by means of in vitro and in vivo assays -- 6.2. Mast cell-induced angiogenesis studied by means of experimental carcinogenesis -- 6.3. Angiogenic factors stored in mast cells -- 6.4. Mast cells and angiogenesis in human solid tumours -- 6.5. Mast cells and angiogenesis in human hematological tumours -- 7. Mast cells and tumour lymphangiogenesis -- 8. Drug affecting mast cells -- Concluding remarks and perspectives -- References.
650 0 $aMast cells.
650 0 $aMast cells$xImmunology.
650 0 $aMast cells$xPhysiology.
650 0 $aTumors.
650 0 $aTumors$xImmunological aspects.
650 12 $aNeoplasms$ximmunology
650 22 $aMast Cells$ximmunology
650 22 $aNeovascularization, Pathologic$ximmunology
650 2 $aMast Cells
650 2 $aNeoplasms
650 6 $aMastocytes.
650 6 $aMastocytes$xImmunologie.
650 6 $aMastocytes$xPhysiologie.
650 6 $aTumeurs.
650 6 $aTumeurs$xImmunologie.
650 7 $aMast cells.$2fast$0(OCoLC)fst01011541
650 7 $aMast cells$xImmunology.$2fast$0(OCoLC)fst01011542
650 7 $aMast cells$xPhysiology.$2fast$0(OCoLC)fst01011543
650 7 $aTumors.$2fast$0(OCoLC)fst01158759
650 7 $aTumors$xImmunological aspects.$2fast$0(OCoLC)fst01158775
655 4 $aElectronic books.
700 1 $aCrivellato, Enrico.
776 08 $iPrint version:$aRibatti, Domenico.$tMast cells and tumours.$dDordrecht : Springer, 2011$w(DLC) 2011927938
856 40 $3ebrary$uhttp://site.ebrary.com/id/10480317
856 40 $3ProQuest Ebook Central$uhttps://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=763340
856 40 $3Scholars Portal$uhttp://books.scholarsportal.info/viewdoc.html?id=/ebooks/ebooks2/springer/2011-09-14/1/9789400714694
856 40 $3SpringerLink$uhttps://doi.org/10.1007/978-94-007-1469-4
856 40 $3SpringerLink$uhttps://link.springer.com/book/10.1007%2F978-94-007-1468-7
856 40 $3SpringerLink$uhttps://link.springer.com/book/10.1007%2F978-94-007-1469-4
856 40 $3VLeBooks$uhttp://www.vlebooks.com/vleweb/product/openreader?id=none&isbn=9789400714694
856 4 $3Cover$uhttp://swbplus.bsz-bw.de/bsz431031843cov.htm$v20150508165200
856 4 $uhttps://discover.gcu.ac.uk/discovery/openurl?institution=44GLCU_INST&vid=44GLCU_INST:44GLCU_VU2&?u.ignore_date_coverage=true&rft.mms_id=991002487415103836$p5372149240003836$xStGlGCU
938 $aAskews and Holts Library Services$bASKH$nAH26422045
938 $aProQuest Ebook Central$bEBLB$nEBL763340
938 $aebrary$bEBRY$nebr10480317
938 $aYBP Library Services$bYANK$n6959613
029 1 $aAU@$b000048656252
029 1 $aDEBSZ$b431031843
029 1 $aNZ1$b13931585
994 $aZ0$bGTX
948 $hNO HOLDINGS IN GTX - 391 OTHER HOLDINGS