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LEADER: 06700cam 2200901Ia 4500
001 ocm60932736
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008 050715s2002 nyua ob 001 0 eng d
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100 1 $aClark, William R.,$d1938-
245 12 $aA means to an end :$bthe biological basis of aging and death /$cWilliam R. Clark.
260 $aNew York ;$aOxford :$bOxford University Press,$c2002.
300 $a1 online resource (xv, 234 pages) :$billustrations
336 $atext$btxt$2rdacontent
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500 $aOriginally published: 1999.
504 $aIncludes bibliographical references and index.
588 0 $aPrint version record.
520 $aWhy do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.; With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders-such as; Werner's syndrome-that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final; chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning.; This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.
505 0 $aAcknowledgments; Introduction; 1. Aging, Senescence, and Lifespan; 2. The Nature of Cellular Senescence and Death; 3. The Evolution of Senescence and Death; 4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan; 5. Human Genetic Diseases That Mimic the Aging Process; 6. Cycling to Senescence; 7. Replicative Immortality: Cancer and Aging; 8. Caloric Restriction and Maximum Lifespan; 9. With Every Breath We Take: Oxidative Stress and Cellular Senescence; 10. The Aging Brain; 11. A Conditional Benefit; Bibliography; Index.
650 0 $aApoptosis.
650 0 $aAging$xMolecular aspects.
650 0 $aCells$xAging.
650 7 $aMEDICAL$xNursing$xGerontology.$2bisacsh
650 7 $aFAMILY & RELATIONSHIPS$xAging.$2bisacsh
650 7 $aAging$xMolecular aspects.$2fast$0(OCoLC)fst00800318
650 7 $aApoptosis.$2fast$0(OCoLC)fst00811467
650 7 $aCells$xAging.$2fast$0(OCoLC)fst00850252
655 0 $aElectronic books.
655 4 $aElectronic books.
776 08 $iPrint version:$aClark, William R., 1938-$tMeans to an end.$dNew York ; Oxford : Oxford University Press, 2002$z0195125932$z0195153758$w(OCoLC)48784366
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