MARC record from Internet Archive

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020 $a9781280448768
024 7 $a10.1002/0470022574$2doi
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060 4 $a2006 B-039
060 4 $aWL 359$bC928m 2006
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082 04 $a616.8/0471$222
100 1 $aCrichton, Robert R.
245 10 $aMetal-based neurodegeneration :$bfrom molecular mechanisms to therapeutic strategies /$cRobert R. Crichton & Roberta J. Ward.
260 $aChichester ;$aHoboken, NJ :$bJ. Wiley & Sons,$c©2006.
300 $a1 online resource (x, 227 pages) :$billustrations (some color)
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
504 $aIncludes bibliographical references and index.
505 0 $aMetals in brain, metal transport, storage and homeostasis -- Oxidative stress and redox-active metal ions -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotrophic lateral sclerosis -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurodegenerative diseases -- Animal models of the various neurodegenerative diseases -- Concluding remarks.
520 $aLooking at each specific neurological disorder in turn, this book outlines the role of metals in human biology, in particular in the brain, and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.
588 0 $aPrint version record.
506 $3Use copy$fRestrictions unspecified$2star$5MiAaHDL
533 $aElectronic reproduction.$b[Place of publication not identified] :$cHathiTrust Digital Library,$d2010.$5MiAaHDL
538 $aMaster and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.$uhttp://purl.oclc.org/DLF/benchrepro0212$5MiAaHDL
583 1 $adigitized$c2010$hHathiTrust Digital Library$lcommitted to preserve$2pda$5MiAaHDL
650 0 $aNervous system$xDegeneration$xEtiology.
650 0 $aBrain$xPathophysiology.
650 0 $aOxidative stress.
650 0 $aMetals$xHealth aspects.
650 2 $aNeurodegenerative Diseases$xetiology.
650 2 $aBrain$xphysiology.
650 2 $aMetals$xadverse effects.
650 2 $aOxidative Stress.
650 7 $aHEALTH & FITNESS$xDiseases$xNervous System (incl. Brain)$2bisacsh
650 7 $aMEDICAL$xNeurology.$2bisacsh
650 7 $aBrain$xPathophysiology.$2fast$0(OCoLC)fst00837648
650 7 $aMetals$xHealth aspects.$2fast$0(OCoLC)fst01018136
650 7 $aOxidative stress.$2fast$0(OCoLC)fst01049566
655 4 $aElectronic books.
700 1 $aWard, Roberta J.
776 08 $iPrint version:$aCrichton, Robert R.$tMetal-based neurodegeneration.$dChichester ; Hoboken, NJ : J. Wiley & Sons, ©2006$z0470022558$w(DLC) 2005023372$w(OCoLC)61334482
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856 40 $3HathiTrust Digital Library, Limited view (search only)$uhttp://catalog.hathitrust.org/api/volumes/oclc/61334482.html
856 40 $3John Wiley$uhttps://doi.org/10.1002/0470022574
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856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/enhancements/fy0645/2005023372-d.html
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