MARC record from Internet Archive

LEADER: 04243cam 2200721 a 4500
001 ocm29772304
003 OCoLC
005 20200519034610.0
008 940326s1994 sz a b 001 0 eng d
010 $a 94136937
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020 $a9783805558563
035 $a(OCoLC)29772304
041 1 $aeng$hfre
042 $alccopycat
050 00 $aRM301.27$b.S6813 1994
050 14 $aRS189$b.S6713 1994
060 00 $a1994 C-815
060 10 $aQV 771$bS769m 1994a
082 00 $a615/.1901$220
084 $a44.38$2bcl
100 1 $aSpriet, Alain.
240 10 $aMe thodologie des essais cliniques des me dicaments.$lEnglish
245 10 $aMethodology of clinical drug trials /$cAlain Spriet, The re se Dupin-Spriet, Pierre Simon ; translated by Robert Coluzzi [and others] ; with a preface by Fernand Sauer.
250 $a2nd, rev. ed.
260 $aBasel ;$aNew York :$bKarger,$c℗♭1994.
300 $aviii, 269 pages :$billustrations ;$c25 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
504 $aIncludes bibliographical references and index.
505 0 $a1. Introduction -- 2. Principles of the controlled trial -- 3. Selection of subjects -- 4. Efficacy assessment -- 5. Randomization -- 6. Single-blind and double-blind trials -- 7. Choice of the comparator: placebo or active drug? -- 8. Dosage and therapeutic schema -- 9. Experimental designs -- 10. Subjects lost to follow-up -- 11. Patient compliance and discontinuation of treatment -- 12. Case report forms -- 13. Multicenter trials -- 14. Imperfect data analysis -- 15. Confirmatory analysis of the principal evaluation criterion -- 16. Interim analyses -- 17. Exploratory analyses -- 18. Pragmatic trials. Decision methods -- 19. Safety data -- 20. Sample size -- 21. Prudence and protection of participants -- 22. Preparing a protocol -- 23. Index.
520 $aThis book is an updated version of the previous work by the same authors which now is out of print (Edition 1985). This manual contains a thorough and didactic presentation of methods currently used including the most modern ones to design clinical trials and to analyse the data obtained.
520 8 $aBased on their own clinical and pharmaceutical industrial experience, the authors explain the "Why" and the "How" of rules which may appear to be fastidious but that are always essential to obtain convincing and reproductible results. Despite the technicals aspects of subject material, the presentation is always clear and unambiguous thanks to the inclusion of tables, graphs, footnotes and references. Solutions based on experience are provided to controversial problems.
520 8 $aThis totally revised work will serve to enhance the knowledge of experienced professional in clinical drug trials.
650 0 $aDrugs$xTesting$xMethodology.
650 12 $aClinical Trials as Topic$xmethods.
650 12 $aDrug Evaluation.
650 7 $aDrugs$xTesting$xMethodology.$2fast$0(OCoLC)fst00898947
650 7 $aKlinische Pru fung$2gnd
650 17 $aGeneesmiddelen.$2gtt
650 17 $aTestmethoden.$2gtt
650 17 $aTesten.$2gtt
650 07 $aKlinische Pru fung.$2swd
653 0 $aDrugs
700 1 $aDupin-Spriet, The re se.
700 1 $aSimon, Pierre,$cM.D.
776 08 $iOnline version:$aSpriet, Alain.$sMe thodologie des essais cliniques des me dicaments. English.$tMethodology of clinical drug trials.$b2nd, rev. ed.$dBasel ; New York : Karger, ℗♭1994$w(OCoLC)621739818
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938 $aBaker and Taylor$bBTCP$n94136937
938 $aYBP Library Services$bYANK$n1254834
029 1 $aAU@$b000011001900
029 1 $aHEBIS$b030608597
029 1 $aNLGGC$b127853855
029 1 $aNLM$b9430971
029 1 $aNZ1$b4420119
994 $aZ0$bP4A
948 $hHELD BY P4A - 88 OTHER HOLDINGS