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020 $a9781402067143$q(electronic bk.)
020 $a1402067143$q(electronic bk.)
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037 $a978-1-4020-6713-6$bSpringer$nhttp://www.springerlink.com
050 4 $aRB147.5$b.M587 2008eb
060 4 $aWD 200.5.M6$bM684 2008
072 7 $aHEA$x039060$2bisacsh
072 7 $aMED$x107000$2bisacsh
072 7 $aMJC$2bicssc
082 04 $a616.042$222
245 00 $aMitochondrial medicine :$bMitochondrial metabolism, diseases, diagnosis and therapy /$cAnna Gvozdja kova , editor.
260 $aDordrecht ;$aLondon :$bSpringer,$c℗♭2008.
300 $a1 online resource (xlv, 409 pages) :$billustrations (chiefly color)
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
504 $aIncludes bibliographical references and index.
588 0 $aPrint version record.
520 $aMitochondrial Medicine is a relatively new area where several disciplines from basic science to clinical medicine converge. Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. A primary feature of mitochondrial dysfunction is impaired cellular bioenergetics. This book is based upon extensive data gathered over 30 years of clinical and experimental research. Internationally recognized authors share their experience and state-of-the-art knowledge in various fields of their expertise such as mitochondrial cardiology, neurology, diabetology, nephrology, immunology, rheumatology, reproductive medicine, sports medicine, and chronobiology, and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects. Laboratory evaluation plays a very important role in the diagnosis of mitochondrial diseases, in addition to clinical assessment. This includes analysis of plasma/mitochondrial coenzyme Q10 content, mitochondrial respiratory chain function and oxidative phosphorylation in isolated mitochondria and biopsy material, and nuclear magnetic resonance methods. In addition to standard medical therapy to treat cardiac, CNS, and other involvements in the mitochondrial disease patients, adjunctive nutritional therapy is indicated primarily to improve mitochondrial function. Therapy include coenzyme Q10, a -lipoic acid, carnitine, w -3- and w -6-PUFA, vitamins and polarized light. Mitochondrial Medicine is dedicated to Dr. Frederick L. Crane, discoverer of Coenzyme Q10 in 1957, and to the Celebration of 50th year of Coenzyme Q10 discovery. This book is intended for general medical practitioners, for specialists such as cardiologists, neurologists, and diabetologists, biochemists, nutritionists, pharmacists, and also for graduate students.
505 0 $aMitochondrial Physiology -- Oxidants, Antioxidants and Oxidative Stress -- Chronobiology, Chronomics and N-of-1 Tests of Timing Coenzyme Q10 -- Methods of Chronobiometric Analysis of Mitochondrial Function -- Mitochondrial Medicine -- Mitochondrial Cardiology -- Mitochondria of the Human Transplanted Heart -- Mitochondrial Diabetology -- Mitochondrial Nephrology -- Mitochondrial Bioenergetics of Skeletal Muscles -- Rheumatoid Arthritis -- Mitochondrial Immunology -- Mitochondrial "Spermatopathy" -- Methods for Diagnosis of Mitochondrial Diseases -- Nuclear Magnetic Resonance -- Clinical Aspects of Coenzyme Q10 in Relationship with Its Bioenergetic and Antioxidant Properties -- Coenzyme Q10 Supplementation in Clinical Medicine -- Coenzyme Q10 Supplementation in Experimental Medicine -- Omega-3-PUFA, Omega-6-PUFA and Mitochondria -- Carnitine -- Vitamins in Mitochondrial Function -- Polarized Light.
650 0 $aMitochondrial pathology.
650 2 $aMitochondrial Diseases$xdiagnosis.
650 2 $aMitochondrial Diseases$xtherapy.
650 2 $aMitochondrial Diseases$xphysiopathology.
650 6 $aMaladies mitochondriales.
650 7 $aHEALTH & FITNESS$xDiseases$xGenetic.$2bisacsh
650 7 $aMEDICAL$xGenetics.$2bisacsh
650 7 $aMitochondrial pathology.$2fast$0(OCoLC)fst01024022
655 4 $aElectronic books.
700 1 $aGvozdja kova , Anna.
776 08 $iPrint version:$tMitochondrial medicine.$dDordrecht ; London : Springer, ℗♭2008$z9781402067136$z1402067135$w(DLC) 2007938214$w(OCoLC)213380083
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