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037 $a978-3-540-25875-9$bSpringer$nhttp://www.springerlink.com
050 4 $aQP905$b.H3 vol. 172
060 4 $aW1$bHA51L v.172 2006
060 4 $aQU 55$bM716253 2006
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245 00 $aMolecular chaperones in health and disease /$ceditor, Matthias Gaestel ; contributors, S. Alberti [and others].
260 $aBerlin ;$aNew York :$bSpringer,$c©2006.
300 $a1 online resource (viii, 442 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $atext file$bPDF$2rda
490 1 $aHandbook of experimental pharmacology ;$vv. 172
504 $aIncludes bibliographical references.
588 0 $aPrint version record.
520 $aMolecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
505 0 $aChaperones in Preventing Protein Denaturation in Living Cells and Protecting Against Cellular Stress -- Feedback Regulation of the Heat Shock Response -- Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response -- Molecular Chaperones in Signal Transduction -- Chaperoning of Glucocorticoid Receptors -- Heat Shock Response: Lessons from Mouse Knockouts -- HSFs in Development -- Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death -- Protein Aggregation as a Cause for Disease -- The Role of Chaperones in Parkinson's Disease and Prion Diseases -- Chaperoning Oncogenes: Hsp90 as a Target of Geldanamycin -- Heat Shock Proteins in Immunity -- Molecular Chaperones and Cancer Immunotherapy -- Hsp90 Inhibitors in the Clinic -- Pharmacological Targeting of Catalyzed Protein Folding: The Example of Peptide Bond cis/trans Isomerases -- Chemical Chaperones: Mechanisms of Action and Potential Use -- Pharmacological Modulation of the Heat Shock Response.
650 0 $aMolecular chaperones$xPhysiological effect.
650 2 $aHeat-Shock Proteins.
650 2 $aHeat-Shock Response.
650 12 $aMolecular Chaperones.
650 7 $aSCIENCE$xLife Sciences$xBiochemistry.$2bisacsh
650 07 $aMolecular chaperones.$2cct
650 07 $aHeat-Shock Proteins.$2cct
650 07 $aHeat-Shock Response.$2cct
650 07 $aMolecular chaperones$xPhysiological effect.$2cct
650 7 $aBiomédecine.$2eclas
650 7 $aSciences de la vie.$2eclas
650 7 $aMolecular chaperones$xPhysiological effect.$2fast$0(OCoLC)fst01024761
653 00 $acelbiologie
653 00 $acellular biology
653 00 $abiochemie
653 00 $abiochemistry
653 00 $afarmacologie
653 00 $apharmacology
653 00 $atoxicologie
653 00 $atoxicology
653 00 $abiomedische wetenschappen
653 00 $abiomedicine
653 10 $aMedicine (General)
653 10 $aGeneeskunde (algemeen)
655 4 $aElectronic books.
700 1 $aGaestel, Matthias.
773 0 $tSpringer e-books
776 08 $iPrint version:$tMolecular chaperones in health and disease.$dBerlin ; New York : Springer, ©2006$z3540258752$z9783540258759$w(DLC) 2005925882$w(OCoLC)61882029
830 0 $aHandbook of experimental pharmacology ;$vv. 172.
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