MARC record from Internet Archive

LEADER: 05261cam 2200625Ki 4500
001 ocn881849371
003 OCoLC
005 20181126235007.0
008 140627s1992 cau o 000 0 eng d
006 m o d
007 cr cnu---unuuu
040 $aOPELS$beng$erda$epn$cOPELS$dN$T$dOCLCQ$dEBLCP$dYDXCP
019 $a895434035
020 $a9781483261874$q(electronic bk.)
020 $a1483261875$q(electronic bk.)
020 $z0124620027
020 $z9780124620025
035 $a(OCoLC)881849371$z(OCoLC)895434035
050 4 $aRB155
072 7 $aSOC$x002020$2bisacsh
082 04 $a573.2$222
245 00 $aMolecular Genetic Medicine /$cedited by Theodore Friedmann.$nVol. 2.
264 1 $aSan Diego :$bAcademic Press,$c1992.
300 $a1 online resource (219 unnumbered pages)
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
588 0 $aPrint version record.
505 0 $aFront Cover; Molecular Genetic Medicine; Copyright Page; Table of Contents; Contributors; Preface; Chapter 1.The Impact of Molecular Biology on the Diagnosis and Treatment of Hemoglobin Disorders; I. DISEASES OF HEMOGLOBIN; II. GLOBIN GENE ORGANIZATION; III. CONTROL OF GLOBIN GENE EXPRESSION; IV. THALASSEMIAS; V. HEMOGLOBINOPATHIES; VI. ANALYSIS OF GLOBIN GENE FUNCTION; VII. SWITCHING; VIII. GENE THERAPY; Acknowledgments; References; Chapter 2.The fragile X Syndrome; I. INTRODUCTION; II. HISTORY OF THE FRAGILE X SYNDROME; III. EPIDEMIOLOGY OF FRAGILE X SYNDROME
505 8 $aIV. FEATURES OF AFFECTED AND TRANSMITTING MALESV. THE ASSOCIATION OF FRAGILE X AND AUTISM; VI. CARRIER FEMALES; VII. CYTOGENETICS OF THE FRAGILE X SYNDROME; VIII. TREATMENT; IX. PRENATAL DIAGNOSIS; X. DNA MOLECULAR MARKERS; XI. THEORIES REGARDING THE NATURE OF THE fra(X) MUTATION; XII. APPROACHES TO DEFINE THE NATURE OF THE MUTATION; XIII. CONCLUSIONS; References; Chapter 3.Hepatitis B Virus Biology and Pathogenesis; I. OVERVIEW OF THE PROBLEM; II. DISCOVERY OF THE VIRUS; III. GENETIC ORGANIZATION OF THE HBV GENOME; IV. VIRAL MORPHOGENESIS; V. HEPATOCELLULAR CARCINOMA
505 8 $aVI. FUTURE PROSPECTS, OPPORTUNITIES, AND CHALLENGESReferences; Chapter 4. The Molecular Genetics of Down Syndrome; I. INTRODUCTION; II. GENE DOSAGE EFFECTS; III. MOLECULAR DEFINITION OF THE DS REGION OF HSA-21; IV. ANIMAL MODELS OF DOWN SYNDROME; V. SUMMARY; Acknowledgments; References; Chapter 5. Mammalian X Chromosome Inactivation; I. INTRODUCTION; II. INITIATION OF X INACTIVATION; III. SPREADING OF THE X INACTIVATION SIGNAL; IV. MAINTENANCE OF X INACTIVATION; V. PERSPECTIVES; Acknowledgments; References
505 8 $aChapter 6. Molecular Analysis of Mutation in the Human Gene for Hypoxanthine PhosphoribosyltransferaseI. INTRODUCTION; II. THE HPRT ENZYME AND CLINICAL FEATURES OF HPRT DEFICIENCY; III. LOCALIZATION, STRUCTURE, AND EXPRESSION OF THE hprt GENE; IV. GERM-LINE MUTATIONS IN HPRT-DEFICIENT PATIENTS; V. SOMATIC hprt MUTATIONS; VI. CONSIDERATIONS ABOUT THE SOMATIC AND GERM-LINE MUTATIONAL SPECTRA IN THE HUMAN hprt GENE; References; Chapter 7. Regulatory Genes of Human Immunodeficiency Viruses; I. INTRODUCTION; II. RETROVIRUS LIFE CYCLE; III. COUPLING OF VIRUS REPLICATION TO CELL CYCLE AND ACTIVATION
505 8 $aIV. HIV REGULATORY GENESV. THE Tat TRANS-ACTIVATION PATHWAY; VI. EXPANDED REPERTOIRE OF Tat ACTIVITIES; VII. THE Rev TRANS-ACTIVATION PATHWAY; VIII. VIRAL PROTEINS; IX. CONCLUSIONS; References; Index
520 $aMolecular Genetic Medicine, Volume II, summarizes progress in several of the most important areas of modern molecular genetics and medicine. The chapters deal with ancient and common genetic diseases, a new infectious disease that threatens to become a world-wide scourge for all of humanity, and two of the most important and still poorly understood causes of mental retardation. The common thread winding through these separate stories is the astounding illumination of all these disorders by modern molecular genetic studies. The book opens with a chapter on the history of the molecular approach.
650 0 $aMedical genetics.
650 0 $aHuman molecular genetics.
650 7 $aSOCIAL SCIENCE$xAnthropology$xPhysical.$2bisacsh
650 7 $aHuman molecular genetics.$2fast$0(OCoLC)fst00963180
650 7 $aMedical genetics.$2fast$0(OCoLC)fst01014133
655 4 $aElectronic books.
655 0 $aElectronic books.
700 1 $aFriedmann, Theodore,$d1935-
776 08 $iPrint version:$tMolecular Genetic Medicine / Vol. 2$z0124620027$w(OCoLC)221068219
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856 40 $3ScienceDirect$uhttp://www.sciencedirect.com/science/book/9780124620025
856 40 $zClick here to view book$uhttp://public.eblib.com/choice/PublicFullRecord.aspx?p=1837310$3Ebook Library
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948 $hNO HOLDINGS IN P4A - 55 OTHER HOLDINGS