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LEADER: 09267cam 2201201Ia 4500
001 ocn262693474
003 OCoLC
005 20211014114808.0
008 081017s2007 gw a ob 001 0 eng d
006 m o d
007 cr cn|||||||||
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024 7 $a10.1007/978-3-540-46320-7$2doi
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037 $a978-3-540-46317-7$bSpringer$nhttp://www.springerlink.com
050 4 $aQD1$b.F58 v.269eb
060 4 $aW1$bTO539LK v.269 2007
060 4 $aQV 744$bN927 2007
070 $a384$bF774 no. 269
072 7 $aTP$2lcco
072 7 $aRS$2lcco
072 7 $aPNN$2bicssc
072 7 $aSCI013040$2bisacsh
082 04 $a541.223$222
084 $aO795$2clc
245 00 $aNovel optical resolution technologies /$cvolume editors, Kenichi Sakai, Noriaki Hirayama, Rui Tamura ; with contributions by G. Coquerel [and others].
260 $aBerlin ;$aNew York :$bSpringer,$c©2007.
300 $a1 online resource (vi, 313 pages) :$billustrations (some color)
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $atext file
347 $bPDF
490 1 $aTopics in current chemistry,$x0340-1022 ;$v269
504 $aIncludes bibliographical references and indexes.
505 0 $aPreferential crystallization / G. Coquerel -- Mechanism and scope of preferential enrichment, a symmetry-breaking enantiomeric resolution phenomenon / R. Tamura [and others] -- Racemization, optical resolution and crystallization-induced assymetric transformation of amino acids and pharmaceutical intermediates / R. Yoshioka -- Advantages of structural similarities of the reactants in optical resolution processes / F. Faigl, J. Schindler, E. Fogassy -- Dutch resolution of racemates and the roles of solid solution formation and nucleation inhibition / R.M. Kellogg, B. Kaptein, T.R. Vries -- New resolution technologies controlled by chiral discrimination mechanisms / K. Sakai, R. Sakurai, H. Nohira -- Molecular mechanisms of dielectrically controlled resolution (DCR) / K. Sakai, R. Sakurai, N. Hirayama -- From racemates to single enantiomers -- chiral synthetic drugs over the last 20 years / H. Murakami.
588 0 $aPrint version record.
520 $aAfter theend ofthe 20th century, the science ofcrystallizationreached a truly exciting stage where new opportunities emerged in both theory and expe- ment. Variousphysical methodsare capableofresolvingthesurface as wellas theinsidestructureofcrystalsattheatomiclevelwhilenewhigh-performance computingresourcesaffordthecapabilityofmodelingthecomplexlarge-scale alignmentsnecessarytosimulatecrystallizationinrealsystems. Asaresult, the science of crystallization has shifted gradually fromstatic to dynamic science and considerable progress now underlies the complex but beautiful cryst- lization process. I believe that if a de?nitive history of 21st century science is ever written, one of the highlightswill be the science ofcrystallization. This science has the following characteristics: in?nite advances in soph- tication, unlimited opportunities not only for intellectual excitement but also forindustrialmerit, strongcollaborationwithbiologyandmaterialscience, as wellaswithallareasofchemistry. Thevastpotentialofcrystallizationasan- portant?eld ofscience isfar beyondthesimple technologyofpharmaceutical industries during the 20th century. Optical resolution was one small area of chemistry in the last century. This was more a technology than a science, largely because trial and error was the only method to obtain good results. However, the situation is now changing. Therearesomanyappealing, hidden?ndingsintheprocessofcrystallization. Historically, crystallization began in an old laboratory in academia and then gradually shifted to industry. Now, it is making itscomeback in academia due toseveralnewresearchbranchestryingtodiscoverwhatisgoingonduringthe crystallizationprocess. Ibelieve this?eld ofscience isnowgrowingasa result of the wonderfulcoupling between industry and academia. I read a prepublication draft of Novel Optical Resolution Technologies, and foundthateachoneofthesegeneralcharacteristicsofsciencehadarealityand sharpness that I had not expected. While it was a sheer delight to revisit each of these triumphs guided by the wise insights and analyses found throughout the book. There is a good balance between the underlying historical material and the design and execution aspects of each topic.
546 $aEnglish.
650 0 $aResolution (Chemistry)$xTechnological innovations.
650 0 $aCrystallization.
650 12 $aChemistry, Pharmaceutical.
650 12 $aCrystallization$xmethods.
650 22 $aOptical Rotation.
650 22 $aStereoisomerism.
650 07 $aCrystallization$xmethods.$2cct
650 07 $aOptical rotation.$2cct
650 07 $aStereoisomerism.$2cct
650 07 $aResolution (Chemistry)$xTechnological innovations.$2cct
650 07 $aCrystallization.$2cct
650 07 $aChemistry, Pharmaceutical.$2cct
650 7 $aChimie.$2eclas
650 7 $aScience des matériaux.$2eclas
650 7 $aCrystallization.$2fast$0(OCoLC)fst00884644
653 00 $achemie
653 00 $achemistry
653 00 $aorganische scheikunde
653 00 $aorganic chemistry
653 10 $aChemistry (General)
653 10 $aChemie (algemeen)
655 4 $aElectronic books.
700 1 $aSakai, Kenichi.
700 1 $aHirayama, Noriaki.
700 1 $aTamura, Rui.
700 1 $aCoquerel, G.$q(Gérard)
776 08 $iPrint version:$tNovel optical resolution technologies.$dBerlin ; New York : Springer, ©2007$z9783540463177$z3540463178$w(OCoLC)85243136
830 0 $aTopics in current chemistry ;$v269.$x0340-1022
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