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245 00 $aPhysico-chemical procedures for the characterization of vaccines :$bLes Pensières, Veyrier-du-Lac, France, December 1-3, 1999 /$cvolume editors, F. Brown, Michael J. Corbel, Elwyn Griffiths.
260 $aBasel ;$aLondon :$bKarger,$c2000.
300 $a278 pages :$billustrations ;$c24 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
490 1 $aDevelopments in biologicals ;$vvol. 103
500 $aProceedings of a symposium.
504 $aIncludes bibliographical references and index.
505 00 $gSess. I.$tCharacterization of Polysaccharide Vaccines and Vaccine Components /$rM. J. Corbel --$gSess. II.$tCharacterization of Protein Subunit Vaccines and Vaccine Components /$rR. Gluck --$gSess. III.$tCharacterization of Glycoconjugate Vaccines and Components /$rM. Van Regenmortel --$gSess. IV.$tCase Studies of Application of Physico-Chemical Methods to Vaccine Evaluation /$rM. D. Lubeck --$gSess. V.$tCase Studies (continued) /$rW. Egan --$gSess. VI.$tCase Studies (continued) /$rJ. Mays --$gSess. VII.$tPoster Session.
520 1 $a"This volume brings together recent developments in the field of physico-chemical procedures and provides a perspective of the contribution that this methodology can make to facilitate the production and quality control of bacterial and viral vaccines." "A growing number of vaccines today is based on well-defined materials, including vaccines based on purified protein antigens of natural origin or produced by rDNA technology, polysaccharides, semi-synthetic poly- or oligosaccharide-protein conjugates and novel nucleic acid constructs. Although in principle much better defined than 'traditional' vaccines, these new products raise new challenges of their own. The realization that biological assays often show limitations in characterizing these vaccines together with mounting social and political pressures to move away from test methods using live animals have shifted interest to methods providing a precise and objective means of characterization at the molecular level as an effective alternative. The growing sophistication of many procedures for physico-chemical analysis has made their application to biological materials a workable reality.".
520 8 $a"This volume contains contributions describing the application of all the principal methods currently in use for evaluating carbohydrate, lipopolysaccharide, lipid, protein, glycoprotein, and lipoprotein components of vaccines, whether produced by conventional methods or recombinant technology. It is clear from the information presented that this approach is gaining momentum and that we are seeing only the beginning of its impact in the field of vaccines and vaccinology."--BOOK JACKET.
650 0 $aVaccines$xAnalysis$vCongresses.
650 12 $aVaccines$xchemistry.$0https://id.nlm.nih.gov/mesh/D014612Q000737
650 22 $aChemistry, Physical$xmethods.$0https://id.nlm.nih.gov/mesh/D002627Q000379
650 22 $aQuality Control.$0https://id.nlm.nih.gov/mesh/D011786
650 7 $aImpfstoff$2gnd
650 7 $aPharmazeutische Analyse$2gnd
650 7 $aKongress$2gnd
653 00 $avaccins
653 00 $avaccines
653 00 $akarakterisering
653 00 $acharacterization
653 00 $afysicochemische eigenschappen
653 00 $aphysicochemical properties
653 00 $alaboratoriummethoden
653 00 $alaboratory methods
653 10 $aPharmacology
653 10 $aFarmacologie
655 2 $aCongress.$0https://id.nlm.nih.gov/mesh/D016423
655 4 $aKongress$zVeyrier-du-Lac$y2000.
655 7 $aConference papers and proceedings.$2fast$0(OCoLC)fst01423772
700 1 $aCorbel, Michael J.
700 1 $aBrown, Fred,$d1925-2004.
700 1 $aGriffiths, E.$q(Elwyn),$d1940-
776 08 $iOnline version:$tPhysico-chemical procedures for the characterization of vaccines.$dBasel ; London : Karger, 2000$w(OCoLC)603697186
830 0 $aDevelopments in biologicals ;$vv. 103.
856 41 $3Table of contents$uhttp://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009348833&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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