MARC record from Internet Archive

LEADER: 06417cam 2200661Ia 4500
001 ocm34404181
003 OCoLC
005 20210511071816.0
008 960319s1996 enka b 001 0 eng d
040 $aGZM$beng$cGZM$dUKM$dWAU$dUBA$dNLGGC$dYDXCP$dDEBBG$dDEBSZ$dOCLCQ$dOCLCO$dOCLCF$dOCLCQ$dBTCTA$dOCLCQ$dHLO$dTHHCU$dOCLCQ$dXFF$dOCLCO$dDHA$dKIJ$dOCLCQ$dOCLCO$dOCLCA$dOCLCQ$dUWO$dOCLCO$dAZU$dDKC
015 $aGB9626465$2bnb
019 $a60278830$a394790176$a1167178975$a1172374835
020 $a0127446400
020 $a9780127446400
035 $a(OCoLC)34404181$z(OCoLC)60278830$z(OCoLC)394790176$z(OCoLC)1167178975$z(OCoLC)1172374835
050 4 $aRS403$b.P73 1996
060 $aQV744$bP722 1996
082 04 $a615.19$220
084 $a44.38$2bcl
084 $aVS 5000$2rvk
084 $aYV 3300$2rvk
084 $aCHE 893f$2stub
084 $aMED 960f$2stub
245 04 $aThe Practice of medicinal chemistry /$cedited by Camille G. Wermuth.
260 $aLondon ;$aSan Diego :$bAcademic Press,$c©1996.
300 $axvii, 968 pages :$billustrations ;$c25 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
504 $aIncludes bibliographical references and index.
505 0 $a1. Medicinal chemistry: Definition and objectives. Drug and disease classifications / Camille G. Wermuth -- 2. Discovering new drugs: the legacy of the past, present approaches, and hopes for the future / Philippe Meyer -- 3. Measurement and expression of drug effects / Jean-Paul Kan -- 4. three main phases of drug activity: the pharmaceutical, the pharmacokinetic and the pharmacodynamic phases / Camille G. Wermuth -- 5. Drug targets -- molecular mechanisms of drug action / Jean-Pierre Gies -- 6. Strategies in the search for new lead compounds or original working hypotheses / Camille G. Wermuth -- 7. Natural products as pharmaceuticals and sources for lead structures / David G. I. Kingston -- 8. Combinatorial libraries and high-throughput synthesis / Sheila Hobbs de Witt -- 9. Synthesis of peptide libraries for lead structure screening / Victor J. Hruby -- 10. contribution of molecular biology to drug discovery / Adrian N. Hobden -- 11. Electronic screening: Lead finding from database mining / Hans-Peter Weber -- 12. Molecular variations in homologous series: Vinylogues and benzologues / Camille G. Wermuth -- 13. Molecular variations based on isosteric replacements / Camille G. Wermuth -- 14. Ring transformations / Camille G. Wermuth -- 15. Identical and nonidentical twin drugs / Jean-Jacques Bourguignon -- 16. Application strategies for primary structure-activity relationship exploration / Camille G. Wermuth -- 17. Specific substituent effects / Camille G. Wermuth -- 18. role of functional groups in drug-receptor interactions / Peter R. Andrews -- 19. Quantitative approaches to structure-activity relationships / Han van de Waterbeemd -- 20. Stereochemical aspects of drug action I: Conformational restriction, steric hindrance and hydrophobic collapse / Phillip A. Hart / Daniel H. Rich -- 21. Stereochemical aspects of drug action II: Optical isomerism / Miklos Simonyi / Gabor Maksay -- 22. Pharmacophore identification and receptor mapping / Hans-Dieter Holtje -- 23. Three-dimensional quantitative structure-activity relationships: D[subscript 2] dopamine agonists as an example / Yvonne Connolly Martin / C. Thomas Lin -- 24. use of X-ray structures of receptors and enzymes in drug discovery / Jean-Michel Rondeau / Herman Schreuder -- 25. Protein homology modelling and drug discovery / Marcel F. Hibert -- 26. transition from agonist to antagonist activity: Symmetry and other considerations / David J. Triggle -- 27. Design of peptidomimetics / Michael Kahn / Hiroshi Nakanishi -- 28. fate of xenobiotics in living organisms / Frans M. Belpaire / Marc G. Bogaert -- 29. Biotransformation reactions / Bernard Testa / Camille G. Wermuth -- 30. Chemical aspects of biotransformations leading to toxic metabolites / Andre Picot / Anne-Christine Macherey -- 31. Designing prodrugs and bioprecursors I: Carrier prodrugs / Jean-Cyr Gaignault / Camille G. Wermuth / Christian Marchandeau -- 32. Designing prodrugs and bioprecursors II: Bioprecursor prodrugs / Camille G. Wermuth -- 33. Macromolecular carriers for drug targeting / Len Seymour / Stefan Vansteenkiste / Etienne H. Schacht -- 34. Preparation of water-soluble compounds through salt formation / Bradley D. Anderson / Karl P. Flora -- 35. Preparation of water-soluble compounds by covalent attachment of solubilizing moieties / Camille G. Wermuth -- 36. Drug solubilization with organic solvents, or using micellar solutions or other colloidal dispersed systems / Kurt H. Bauer -- 37. Improvement of drug properties by cyclodextrin / Kaneto Uekama / Fumitoshi Hirayama -- 38. Chemical and physicochemical solutions to formulation problems / Camille G. Wermuth -- 39. From discovery to market availability / Jacques A. Dangoumau -- 40. Drug nomenclature / Sabine Kopp-Kubel -- 41. Legal aspects of product protection -- what a medicinal chemist should know about patent protection / Maria Souleau -- 42. consumption and production of pharmaceuticals / Bryan G. Reuben.
650 0 $aPharmaceutical chemistry.
650 7 $aPharmaceutical chemistry.$2blmlsh
650 7 $aDrugs.$2blmlsh
650 7 $aPharmaceutical chemistry.$2fast$0(OCoLC)fst01060115
650 17 $aFarmacochemie.$2gtt
650 17 $aDrug targeting.$2gtt
650 17 $aStructuur-activiteit-relatie.$2gtt
650 17 $aReceptoren.$2gtt
650 17 $aFarmacokinetica.$2gtt
650 7 $aPharmazeutische Chemie$2gnd
650 7 $aQuimica farmaceutica.$2larpcal
650 2 $aChemistry, Pharmaceutical.
653 0 $aDrugs
700 1 $aWermuth, C. G.
776 08 $iOnline version:$tPractice of medicinal chemistry.$dLondon ; San Diego : Academic Press, ©1996$w(OCoLC)645871436
856 41 $3Table of contents$uhttp://www.gbv.de/dms/bs/toc/190479590.pdf$zKostenfrei
938 $aBaker and Taylor$bBTCP$nBK0016781198
938 $aYBP Library Services$bYANK$n60854
029 1 $aAU@$b000044021147
029 1 $aAU@$b000045206460
029 1 $aDEBBG$bBV010889122
029 1 $aDEBSZ$b053689291
029 1 $aHEBIS$b051781085
029 1 $aNLGGC$b142575623
029 1 $aYDXCP$b60854
994 $aZ0$bP4A
948 $hNO HOLDINGS IN P4A - 177 OTHER HOLDINGS