MARC record from Internet Archive

LEADER: 05035cam 2200781Ma 4500
001 ocn840294960
003 OCoLC
005 20200525173536.0
008 121227s1987 gw a o 000 0 eng d
006 m o e
007 cr nn|||||||||
040 $aI9W$beng$epn$cI9W$dOCLCO$dUV0$dOCLCQ$dOCLCO$dOCLCF$dGW5XE$dCOO$dEBLCP$dOCLCQ$dYDX$dUAB$dOCLCQ$dAU@$dOCLCQ
019 $a968654951$a1012479996
020 $a9783642729027$q(electronic bk.)
020 $a3642729029$q(electronic bk.)
020 $a9783642729041$q(print)
020 $a3642729045$q(print)
020 $a9783540181873
020 $a3540181873
024 7 $a10.1007/978-3-642-72902-7$2doi
035 $a(OCoLC)840294960$z(OCoLC)968654951$z(OCoLC)1012479996
050 4 $aQH345
082 04 $a572$223
100 1 $aBartle, W. R.
245 10 $aRegulation of Plasma Low Density Lipoprotein Levels Biopharmacological Regulation of Protein Phosphorylation Calcium-Activated Neutral Protease Microbial Iron Transport Pharmacokinetic Drug Interactions /$cby W.R. Bartle, V. Braun, J.M. Dietschy, Y. Emori, M. Hagiwara, H. Hidaka, S. Imajoh, H. Kawasaki, J.B. Meddings, S. Ohno, K. Suzuki, S.E. Walker, G. Winkelmann, N.E. Winslade.
260 $aBerlin, Heidelberg :$bSpringer Berlin Heidelberg,$c1987.
300 $a1 online resource (VII, 134 pages 59 illustrations)
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
490 1 $aProgress in Clinical Biochemistry and Medicine, 0177-8757 ;$v5
505 0 $aRegulation of Plasma Low Density Lipoprotein Levels: New Strategies for Drug Design -- Biopharmacological Regulation of Protein Phosphorylation -- Calcium-Activated Neutral Protease (CANP) and its Biological and Medical Implications -- Microbial Iron Transport -- Structure and Function of Siderophores -- Pharmacokinetic Drug Interactions -- Author Index Volumes 1-5.
520 $aCholesterol is essential for normal cellular function. It is found in all cells of the body and is a major constituent of cell membranes. In addition, certain specialized tissues use cholesterol as the basic substrate for the synthesis of more complicated sterols such as bile acids and the steroid hormones. Like most lipids cholesterol has a very low solubility in water. Therefore, in order for these molecules to be transported be­ tween different organs of the body a series of lipid carriers known as lipoproteins has evolved. Over the last several years epidemiological evidence has accumulated suggest­ ing a strong relationship between the risk of atherosclerosis and high plasma concen­ trations of one of these lipoproteins, low density lipoprotein (LDL) 1). Thus, in popula­ tions with high plasma concentrations of LDL-cholesterol a correspondingly high incidence of vascular disease is seen. Since it has been demonstrated that reducing the steady-state plasma LDL-cholesterol concentration produces a proportional decrease in the risk of developing atherosclerosis 2), a major effort is now underway to develop safe and effective lipid lowering agents. In the past, these efforts have been hampered by a lack of knowledge concerning the physiological regulation of the plasma LDL-cholesterol concentration. However, recently there have been several major advances in these areas and it is now possible to precisely determine those factors that have the greatest effect on either increasing or decreasing the plasma LDL-cholesterol concentration.
650 0 $aLife sciences.
650 0 $aNeurosciences.
650 0 $aBiochemistry.
650 0 $aZoology.
650 7 $aBiochemistry.$2fast$0(OCoLC)fst00831961
650 7 $aLife sciences.$2fast$0(OCoLC)fst00998323
650 7 $aNeurosciences.$2fast$0(OCoLC)fst01036509
650 7 $aZoology.$2fast$0(OCoLC)fst01184696
655 4 $aElectronic books.
700 1 $aBraun, V.
700 1 $aDietschy, J. M.
700 1 $aEmori, Y.
700 1 $aHagiwara, M.
700 1 $aHidaka, H.
700 1 $aImajoh, S.
700 1 $aKawasaki, H.
700 1 $aMeddings, J. B.
700 1 $aOhno, S.
700 1 $aSuzuki, K.
700 1 $aWalker, S. E.
700 1 $aWinkelmann, G.
700 1 $aWinslade, N. E.
776 08 $iPrinted edition:$z9783642729041
830 0 $aProgress in clinical biochemistry and medicine ;$v5.
856 40 $3ProQuest Ebook Central$uhttp://public.ebookcentral.proquest.com/choice/publicfullrecord.aspx?p=3092505
856 40 $3SpringerLink$uhttps://doi.org/10.1007/978-3-642-72902-7
856 40 $3SpringerLink$uhttps://link.springer.com/openurl?genre=book&isbn=978-3-540-18187-3
856 40 $3SpringerLink$uhttp://link.springer.com/10.1007/978-3-642-72902-7
938 $aProQuest Ebook Central$bEBLB$nEBL3092505
938 $aYBP Library Services$bYANK$n13361653
029 1 $aAU@$b000051693154
029 1 $aNZ1$b15002031
029 1 $aNZ1$b15588404
994 $aZ0$bP4A
948 $hNO HOLDINGS IN P4A - 54 OTHER HOLDINGS