| Record ID | ia:selectiveestroge0000unse |
| Source | Internet Archive |
| Download MARC XML | https://archive.org/download/selectiveestroge0000unse/selectiveestroge0000unse_marc.xml |
| Download MARC binary | https://www.archive.org/download/selectiveestroge0000unse/selectiveestroge0000unse_meta.mrc |
LEADER: 03743cam 22007094a 4500
001 ocm46970654
003 OCoLC
005 20200515023612.0
008 010509s2002 njua b 001 0 eng
010 $a 2001026442
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050 00 $aRG186$b.S44 2002
060 00 $a2002 C-081
060 10 $aWP 522$bS464 2002
082 00 $a618.1/75$221
245 00 $aSelective estrogen receptor modulators :$bresearch and clinical applications /$cedited by Andrea Manni, Michael F. Verderame.
260 $aTotowa, N.J. :$bHumana Press,$c℗♭2002.
300 $ax, 373 pages :$billustrations ;$c27 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
490 1 $aContemporary endocrinology
504 $aIncludes bibliographical references and index.
520 $aExperimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
650 0 $aSelective estrogen receptor modulators.
650 0 $aMenopause$xHormone therapy.
650 12 $aSelective Estrogen Receptor Modulators.
650 22 $aPostmenopause$xdrug effects.
650 22 $aEstrogen Replacement Therapy$xmethods.
650 22 $aReceptors, Estrogen$xphysiology.
650 7 $aMenopause$xHormone therapy.$2fast$0(OCoLC)fst01016254
650 7 $aSelective estrogen receptor modulators.$2fast$0(OCoLC)fst01111386
650 7 $aO strogenrezeptor$2gnd
650 7 $aO strogen-Rezeptor-Modulator$2gnd
650 7 $aMenopause$2gnd
650 7 $aO strogene$2gnd
650 7 $aSubstitutionstherapie$2gnd
700 1 $aManni, Andrea.
700 1 $aVerderame, Michael,$d1957-
830 0 $aContemporary endocrinology (Totowa, N.J.)
856 41 $3Table of contents$uhttp://catdir.loc.gov/catdir/enhancements/fy0825/2001026442-t.html
856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/enhancements/fy0825/2001026442-d.html
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948 $hNO HOLDINGS IN P4A - 79 OTHER HOLDINGS