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LEADER: 05235cam 2200625Ia 4500
001 ocm30694319
003 OCoLC
005 20200623064034.0
008 940630s1994 enkaf b 001 0 eng d
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020 $a0123763509
020 $a9780123763501
035 $a(OCoLC)30694319
050 4 $aQP364.7$b.S54 1994
060 $aWL 102.8 S577 1994
082 04 $a612.82$bSi25$220
084 $aWW 4250$2rvk
245 00 $aSigma receptors /$cedited by Y. Itzhak.
260 $aLondon ;$aSan Diego :$bAcademic Press,$c©1994.
300 $axvii, 340 pages, 1 unnumbered leaf of plates :$billustrations (some color) ;$c24 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
338 $avolume$bnc$2rdacarrier
490 1 $aNeuroscience perspectives
504 $aIncludes bibliographical references and index.
505 0 $aHistorical perspective: evolution of the concept of sigma receptors / W.R. Martin and J.W. Sloan -- Sigma receptors in the central nervous system and the periphery / Tsung-Ping Su and Jean-Louis Junien -- Structure-activity relationships and evolution of sigma receptor ligands (1976-present) / Brian R. de Costa and Xiao-shu He -- Multiple sigma binding sites in the brain / Yossef Itzhak -- Interaction of sigma receptors with signal transduction pathways and effects on second messengers / Wayne D. Bowen -- Recent evidence for endogenous substance(s) for sigma receptors / Terrell A. Patterson, Mark Connor and Charles Chavkin -- Potential therapeutic application of sigma receptor antagonists / S. William Tam -- Role of sigma receptors in brain mechanisms of movement / J. Michael Walker [and others] -- Imaging sigma receptors and cerebral responses to sigma drugs / Kenji Hashimoto and Edythe D. London -- Effects of cytochrome P-450 ligands on the binding of [³H]dextromethorphan and sigma ligands to guinea-pig brain / Martin Klein and José M. Musacchio -- Putative interactions between sigma receptors and neuropeptide Y / Guy Debonnel [and others] -- Role of sigma binding sites in the modulation of endocrine and immune functions / Seth A. Wolfe, Jr. and Errol B. De Souza -- Sigma receptor: concluding remarks/future vistas / Leslie Kushner and R. Suzannne Zurkin.
520 $aNeuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.
520 8 $aThe sigma receptor was originally thought to be a subset of the opioid receptor family, and it is less than 10 years since it was recognized that this receptor represents unique binding sites in mammalian brain and peripheral organs, distinct from any other known neurotransmitter receptor.
520 8 $aSince the sigma receptors exhibit high affinity for members of diverse classes of psychotropic drugs, and have been postulated to be involved in various central nervous disorders, neuroscientists have demonstrated a great deal of interest in the elucidation of these receptor sites and their biological relevance. Relatively little is known about the precise role of sigma receptors in normal brain function and in CNS disorders, despite an overwhelming research effort. This research has resulted in many controversies, some of which have been reconciled while others have not.
520 8 $aThis volume aims to update the reader on the current situation, and deals with the potential functional significance of these receptors in the brain and peripheral organs and, where appropriate, makes reference to the clinical potential of these sites.
650 0 $aNeurotransmitter receptors.
650 0 $aNeural receptors.
650 0 $aNeurotransmitter receptors$xEffect of drugs on.
650 0 $aNeural receptors$xEffect of drugs on.
650 7 $aNeural receptors.$2fast$0(OCoLC)fst01036274
650 7 $aNeurotransmitter receptors.$2fast$0(OCoLC)fst01036563
650 7 $aOpiatrezeptor$2gnd
650 7 $aSystème nerveux central.$2ram
650 2 $aBinding Sites.
650 2 $aNervous System$xdrug effects.
650 2 $aReceptors, sigma.
653 0 $aMammals$aNeurotransmitters
700 1 $aItzhak, Y.$q(Yossef)
776 08 $iOnline version:$tSigma receptors.$dLondon ; San Diego : Academic Press, ©1994$w(OCoLC)608107244
776 08 $iOnline version:$tSigma receptors.$dLondon ; San Diego : Academic Press, ©1994$w(OCoLC)624397056
830 0 $aNeuroscience perspectives.
938 $aBaker & Taylor$bBKTY$c160.00$d160.00$i0123763509$n0002469213$sactive
938 $aYBP Library Services$bYANK$n57503
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948 $hNO HOLDINGS IN P4A - 108 OTHER HOLDINGS