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LEADER: 08589cam 22012014a 4500
001 ocm67615216
003 OCoLC
005 20200513101621.0
008 050609s2005 sz a ob 001 0 eng c
006 m o d
007 cr |n|||||||||
010 $a 2005048122
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020 $a3764370807$q(alk. paper)
020 $a9783764370800
020 $a3764373792$q(electronic bk.)
020 $a9783764373795$q(electronic bk.)
020 $a6610413460$q(electronic bk.)
020 $a9786610413461$q(electronic bk.)
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037 $a978-3-7643-7080-0$bSpringer$nhttp://www.springerlink.com
042 $apcc
050 4 $aQP451.4$b.T87 2005
060 4 $a2005 M-648
060 4 $aQV 38$bT955 2005
072 7 $aMED$x057000$2bisacsh
072 7 $aPSY$x020000$2bisacsh
082 04 $a612.8/8$222
084 $aR339. 1$2clc
245 00 $aTurning up the heat on pain :$bTRPV1 receptors in pain and inflammation /$cAnnika B. Malmberg, Keith R. Bley, editors.
260 $aBasel ;$aBoston :$bBirkhauser Verlag,$c©2005.
300 $a1 online resource (xii, 249 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
490 1 $aProgress in inflammation research
504 $aIncludes bibliographical references and index.
505 0 $aPart I: Historical perspective on capsaicin and its receptor. Hot peppers, pain and analgesics / János Szolcsányi -- Part II: Molecular and cellular properties of vanilloid receptors. Structural determinants of TRPV1 functionality / Makoto Tominaga ; TRPV1 distribution and regulation / Janet Winter -- Part III: Pharmacology and physiology of vanilloid receptors. Insights into TRPV1 pharmacology provided by non-capsaicin ligands / Peter M. Blumberg, Derek C. Braun, Noemi Kedei, Jozsef Lazar, Vladimir Pavlyukovets and Larry V. Pearce ; Endocannabinoids and vanilloid TRPV1 receptors / Ruth A. Ross ; Vanilloid receptor-mediated hyperalgesia and desensitization / Zoltán Sándor and Arpad Szallasi ; Capsaicin in human experimental pain models of skin, muscle and visceral sensitization / Lars Arendt-Nielsen and Ole K. Andersen -- Part IV: Vanilloid receptor involvement in disease states. TRPV1 in gut function, abdominal pain and functional bowel disorders / Peter Holzer ; TRPV1 in the airways / Maria G. Belvisi and Peter J. Barnes -- Part V: Therapeutic potential of vanilloid agonists and antagonists. TRPV1 agonist-based therapies: mechanism of action and clinical prospects / Keith R. Bley and Annika B. Malmberg ; TRPV1 agonist therapies in bladder diseases / Francisco Cruz, Carlos Silva and Paulo Dinis ; TRPV1 antagonists and chronic pain / Kenneth J. Valenzano, James D. Pomonis and Katharine Walker.
520 $aVanilloids mediate their effects by selective agonism of an ion channel, the vanilloid receptor 1 (TRPV1). TRPV1 is a ligand-gated, non-selective, cation channel preferentially expressed in small-diameter, primary afferent neurons, including nociceptive sensory nerves. In addition to be activated by capsaicin and related vanilloids, TRPV1 responds to heat and extracellular acidification, and will integrate simultaneous exposures to these stimuli. The aim of this book is to summarize recent insights in the role of TRPV1 in pain and inflammation, and to discuss how modulation of this receptor ma.
650 0 $aNociceptors.
650 0 $aPain.
650 0 $aInflammation.
650 0 $aInflammation$xMediators.
650 12 $aReceptors, Drug$xantagonists & inhibitors.
650 12 $aReceptors, Drug$xphysiology.
650 22 $aCapsaicin$xanalogs & derivatives.
650 22 $aCapsaicin$xpharmacology.
650 22 $aInflammation$xdrug therapy.
650 22 $aPain$xdrug therapy.
650 7 $aMEDICAL$xNeuroscience.$2bisacsh
650 7 $aPSYCHOLOGY$xNeuropsychology.$2bisacsh
650 07 $aPain.$2cct
650 07 $aInflammation.$2cct
650 07 $aInflammation$xMediators.$2cct
650 07 $aNociceptors.$2cct
650 7 $aInflammation.$2fast$0(OCoLC)fst00972432
650 7 $aInflammation$xMediators.$2fast$0(OCoLC)fst00972436
650 7 $aNociceptors.$2fast$0(OCoLC)fst01038309
650 7 $aPain.$2fast$0(OCoLC)fst01050382
650 7 $aNozizeptor$xSchmerz$xEntzündung.$2swd
650 7 $aSchmerz$xNozizeptor$xEntzündung.$2swd
650 7 $aEntzündung$xSchmerz$xNozizeptor.$2swd
655 4 $aElectronic books.
700 1 $aMalmberg, Annika B.,$d1966-
700 1 $aBley, Keith R.
773 0 $tSpringer e-books
776 08 $iPrint version:$tTurning up the heat on pain.$dBasel ; Boston : Birkhauser Verlag, ©2005$z3764370807$w(DLC) 2005048122$w(OCoLC)60651130
830 0 $aPIR (Series)
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856 40 $3SpringerLink$uhttps://link.springer.com/10.1007/3-7643-7379-2
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856 42 $3Publisher description$uhttp://catdir.loc.gov/catdir/enhancements/fy0662/2005048122-d.html
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