MARC Record from marc_columbia

LEADER: 03257fam a2200361 a 4500
001 1682315
005 20220608211855.0
008 940609s1994 enka b 001 0 eng
010 $a 94026309
020 $a0521449502 (pbk.)
020 $a0521445000
035 $a(OCoLC)30701944
035 $a(OCoLC)ocm30701944
035 $9AKV0382CU
035 $a(NNC)1682315
035 $a1682315
040 $aDLC$cDLC$dDLC$dOrLoB
050 00 $aQP601.3$b.S38 1994
082 00 $a574.19/25$220
100 1 $aSchulz, Arthur R.$0http://id.loc.gov/authorities/names/n94055408
245 10 $aEnzyme kinetics :$bfrom diastase to multi-enzyme systems /$cArthur R. Schulz.
260 $aCambridge ;$aNew York :$bCambridge University Press,$c1994.
300 $ax, 246 pages :$billustrations ;$c23 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
504 $aIncludes bibliographical references and indexes.
505 00 $gPt. 1.$tBasic steady state enzyme kinetics.$g1.$tDerivation of a rate equation.$g2.$tA closer look at the basic assumptions.$g3.$tEnzyme inhibition.$g4.$tReversible enzyme-catalyzed reactions --$gPt. 2.$tEnzyme reaction sequence.$g5.$tMulti-reactant enzymic reactions.$g6.$tAnalysis of multi-reactant enzyme kinetics.$g7.$tPrediction of reaction sequence.$g8.$tEnzyme-catalyzed isotopic exchange.$g9.$tKinetic isotope effect on steady state parameters.$g10.$tThe effect of pH on enzyme kinetics --$gPt. 3.$tNon-hyperbolic enzyme kinetics.$g11.$tThe causes of non-hyperbolic enzyme kinetics.$g12.$tAnalysis of non-hyperbolic enzyme kinetics.$g13.$tThe effect of subunit interactions on enzyme kinetics --$gPt. 4.$tControl of multi-enzyme systems.$g14.$tControl of linear multi-enzyme systems.$g15.$tControl of branched multi-enzyme systems.$g16.$tBiochemical systems theory --$gPt. 5.$tSolutions to problems.
520 $aThis textbook for advanced courses in enzyme chemistry and enzyme kinetics covers the field of steady state enzyme kinetics from the basic principles inherent in the Henri equation to the expressions which describe the control of multi-enzyme pathways.
520 8 $aSteady state kinetic equations are derived with the use of the connection matrix method, and an algorithm which can be implemented easily for computer-based derivation of the equations is developed. Throughout the book emphasis is placed on a proper interpretation of the kinetic behavior of multi-reactant enzymic reactions.
520 8 $aThe principles of analytical geometry and basic calculus are employed to analyze non-hyperbolic substrate saturation curves in terms of the mechanisms, including subunit interactions, which cause the deviation from hyperbolic curves. Sensitivity theory is employed to obtain expressions for flux and concentration control coefficients for multi-enzyme pathways. The algorithm developed can be incorporated into a computer-based program for derivation. Emphasis is placed on the interpretation of control coefficients in terms of metabolic control.
520 8 $aProblems are included at the end of each chapter and their solutions are found at the end of the book.
650 0 $aEnzyme kinetics.$0http://id.loc.gov/authorities/subjects/sh87003634
852 00 $bsci$hQP601.3$i.S38 1994