| Record ID | marc_columbia/Columbia-extract-20221130-007.mrc:178129588:3577 |
| Source | marc_columbia |
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LEADER: 03577mam a22004694a 4500
001 3154570
005 20221019234159.0
008 010123t20012001ctua b 001 0 eng
010 $a 2001017701
020 $a0300085400 (alk. paper)
035 $a(OCoLC)ocm45804765
035 $9ATZ2677CU
035 $a(NNC)3154570
035 $a3154570
040 $aDLC$cDLC$dC#P$dCOU$dOrLoB-B
042 $apcc
043 $an-us-ca
050 00 $aQP624$b.H654 2001
082 00 $a572.8/6$221
096 $aQU 11 AC2$bH749m 2001
100 1 $aHolmes, Frederic Lawrence.$0http://id.loc.gov/authorities/names/n84016808
245 10 $aMeselson, Stahl, and the replication of DNA :$ba history of "the most beautiful experiment in biology " /$cFrederic Lawrence Holmes.
260 $aNew Haven :$bYale University Press,$c[2001], ©2001.
300 $axii, 503 pages :$billustrations ;$c25 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
504 $aIncludes bibliographical references (p. [449]-496) and index.
505 00 $gCh. 1.$tThe Replication Problem --$gCh. 2.$tMeselson and Stahl --$gCh. 3.$tTwists and Turns --$gCh. 4.$tCrossing Fields: Chemical Bonds to Biological Mutants --$gCh. 5.$tDense Solutions --$gCh. 6.$tThe Big Machine --$gCh. 7.$tWorking at High Speed --$gCh. 8.$tThe Unseen Band --$gCh. 9.$tOne Discovery, Three Stories --$gCh. 10.$tAn Extremely Beautiful Experiment --$gCh. 11.$tCentrifugal Forces --$gCh. 12.$tThe Subunits of Semiconservative Replication --$gCh. 13.$tImages of an Experiment --$gCh. 14.$tAfterword.
520 1 $a"In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest.".
520 8 $a"This book reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research - its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty.
520 8 $aHolmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment."--BOOK JACKET.
650 0 $aDNA replication$xExperiments$xHistory.
600 10 $aMeselson, Matthew.$0http://id.loc.gov/authorities/names/n78048895
600 10 $aStahl, Franklin W.$0http://id.loc.gov/authorities/names/n79047580
650 0 $aMolecular biology$xExperiments$xHistory.
600 12 $aMeselson, Matthew.
600 12 $aStahl, Franklin W.
650 12 $aDNA Replication.$0https://id.nlm.nih.gov/mesh/D004261
650 12 $aMolecular Biology$xhistory.$0https://id.nlm.nih.gov/mesh/D008967Q000266
650 12 $aResearch$xhistory.$0https://id.nlm.nih.gov/mesh/D012106Q000266
651 2 $aCalifornia.$0https://id.nlm.nih.gov/mesh/D002140
852 00 $boff,bio$hQP624$i.H654 2001