| Record ID | marc_columbia/Columbia-extract-20221130-008.mrc:542242531:3165 |
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LEADER: 03165fam a2200373 a 4500
001 3979836
005 20221027012942.0
008 930311t19931993enka b 001 0 eng c
010 $a 93017041
020 $a052141296X (hc)
035 $a(OCoLC)27854548
035 $a(OCoLC)ocm27854548
035 $9AHV0388HS
035 $a(NNC)3979836
035 $a3979836
040 $aDNLM/DLC$cDLC$dDLC$dNNC-M
050 00 $aRM301.3.G45$bP75 1993
060 0 $aQV 38 P945g 1993
082 00 $a615/.7$220
100 1 $aPrice Evans, David A.$0http://id.loc.gov/authorities/names/n93801090
245 10 $aGenetic factors in drug therapy :$bclinical and molecular pharmacogenetics /$cDavid A. Price Evans.
260 $aCambridge ;$aNew York, NY :$bCambridge University Press,$c[1993], ©1993.
300 $axxiii, 657 pages :$billustrations ;$c26 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
504 $aIncludes bibliographical references and index.
505 2 $a1. The arrangement of the information in this volume -- 2. General introduction -- 3. Classification of pharmacogenetic phenomena -- 4. Cytochromes P450 - general features -- 5. Arylhydrocarbon hydroxylase (cytochrome P450 lA1 and lA2) -- 6. The mephenytoin hydroxylation polymorphism (cytochrome P450 2C18) -- 7. The debrisoquine/sparteine polymorphism (cytochrome P450 2D6) -- 8. The cytochrome P450 3A subfamily -- 9. Tolbutamide -- 10. Phenytoin -- 11. Some other drugs of special interest -- 12. Cytochrome P450 reductase -- 13. General conclusions -- 14. Cholinesterase -- 15. Alcohol and alcoholism -- 16. N-Acetyltransferase -- 17. The glucosidation of amobarbital -- 18. Glucuronosyltransferases -- 19. Glutathione-S-transferase -- 20. Methylation reactions -- 21. Paraoxonase -- 22. Sulphotransferases -- 23. Sulphoxidation deficiency -- 24. Halothane hepatitis and other topics -- 25. Glucose-6-phosphate dehydrogenase deficiency -- 26. The hepatic porphyrias -- 27. Malignant hyperthermia.
505 0 $a28. Chlorpropamide-alcohol flushing -- 29. Glucocorticosteroids and intraocular pressure -- 30. Unstable haemoglobins -- 31. Human lymphocyte antigens and adverse reactions to drugs -- 32. The polymorphism for tasting phenylthiocarbamide (PTC syn phenylthiourea) -- 33. Hereditary anticoagulant resistance -- 34. NADH-cytochrome b5 reductase -- 35. Catalase -- 36. Antibiotic-induced deafness, chloramphenicol toxicity and other topics -- 37. Polygenic effects in pharmacogenetics -- 38. Common themes -- 39. Conclusions -- Appendix I Computing the degree of dominance -- Appendix II Exponential decay -- Appendix III The disentanglement of overlapping frequency distribution curves -- Appendix IV Chromosomal locations of genes.
650 0 $aPharmacogenetics.$0http://id.loc.gov/authorities/subjects/sh85100595
650 2 $aPharmacogenetics.$0https://id.nlm.nih.gov/mesh/D010597
650 2 $aDrug Therapy.$0https://id.nlm.nih.gov/mesh/D004358
650 2 $aGenetics, Medical.$0https://id.nlm.nih.gov/mesh/D005826
650 2 $aGenetic Variation$xdrug effects.$0https://id.nlm.nih.gov/mesh/D014644Q000187
852 00 $boff,hsl$hRM301.3.G45$iP75 1993