MARC Record from marc_columbia

LEADER: 06051cam a2200781Ma 4500
001 4239423
005 20220625225513.0
006 m o d
007 cr cn|||||||||
008 020517s2002 nyua ob 001 0 eng d
035 $a(OCoLC)ocm50175012
035 $a(NNC)4239423
040 $aN$T$beng$epn$cN$T$dOCLCQ$dYDXCP$dOCLCQ$dTUU$dOCLCQ$dTNF$dTULIB$dOCLCQ$dZCU$dOCLCO$dEBLCP$dCNTRU$dOKU$dNLGGC$dGW5XE$dOCLCF$dGW5XE$dOCLCQ$dDEBSZ$dOCLCQ$dMWM$dSUR$dUAB$dOCLCQ$dSAV$dOCLCQ$dQT7$dLUE$dOCLCQ$dINT$dTOF$dOCLCQ$dNOC$dWURST$dOCLCO
019 $a55046180$a320976031$a517795042$a533449378$a702098256$a818973008$a961601075$a962719020$a970777096$a984884788$a1007372779$a1053006487$a1135385140
020 $a0306468336$q(electronic bk.)
020 $a9780306468339$q(electronic bk.)
020 $z0306464276
020 $z9780306464270
035 $a(OCoLC)50175012$z(OCoLC)55046180$z(OCoLC)320976031$z(OCoLC)517795042$z(OCoLC)533449378$z(OCoLC)702098256$z(OCoLC)818973008$z(OCoLC)961601075$z(OCoLC)962719020$z(OCoLC)970777096$z(OCoLC)984884788$z(OCoLC)1007372779$z(OCoLC)1053006487$z(OCoLC)1135385140
050 4 $aQP519.9.R28$bC63 2002eb
060 4 $aWN 415
072 7 $aMED$x106000$2bisacsh
082 04 $a610/.7/2$221
084 $a44.64$2bcl
049 $aZCUA
100 1 $aCobelli, Claudio,$eauthor.
245 10 $aTracer kinetics in biomedical research :$bfrom data to model /$cClaudio Cobelli, David Foster, and Gianna Toffolo.
260 $aNew York :$bKluwer Academic,$c©2002.
300 $a1 online resource (xi, 456 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
504 $aIncludes bibliographical references and index.
520 $aThe use of mathematical modeling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is key in understanding the functional characteristics of gene expression and protein assembly and secretion. Finally, with the increasing complexity and associated cost of drug development, modeling techniques are being used to streamline the process. This book is designed to give the reader the mathematical and statistical information necessary to design tracer kinetic studies, to use noncompartmental methodologies and/or to develop multicompartmental models to interpret the data. The book starts with a review of fundamentals of radioactive and stable isotope tracer kinetics and then proceeds with a description of the noncompartmental and multicompartmental modeling methodologies to study systems in the steady state. The focus is on understanding the basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess how `good' a model is and on giving some hints on how better to design kinetic studies, in order to increase the probability of a successful study and to ensure the maximal information content in the experimental data to be extracted. The book has an extensive section on parameter estimation, i.e., fitting models to data, first in general terms and then specifically related to noncompartmental and compartmental models. This is written from a basic point of view, and is intended to remove the mystery from the `black box' of computer optimization software. Finally, a special application often found in tracer kinetic analysis, precursor-product relationships, is discussed. Throughout the book, the goal is to provide even the novice with sufficient background so that he/she can feel comfortable. A number of case studies, based upon real experimental data, are carried through the text. Other examples illustrate specific points. All data examples are provided on a floppy disk.
505 0 $aIntroduction -- Fundamentals of tracer kinetics -- The noncompartmental model of multipool systems: accessible pool an dsystem parameters -- The compartmental model -- Indentifiability of the tracer model -- Using the tracer model to estimate kinetic parameters -- Compartmental versus noncompartmental kinetic parameters -- Parameter estimation: some fundamentals of regression analysis -- Paramter estimation in noncompartmental models -- Parameter estimation in compartmental models -- Precursor-product models -- Appendices -- Index.
588 0 $aPrint version record.
650 0 $aRadioactive tracers in biochemistry$xMathematics.
650 0 $aPharmacokinetics$xMathematics.
650 6 $aTraceurs radioactifs en biochimie$xMathématiques.
650 6 $aPharmacocinétique$xMathématiques.
650 7 $aMEDICAL$xResearch.$2bisacsh
650 7 $aPharmacokinetics$xMathematics.$2fast$0(OCoLC)fst01060255
650 7 $aRadioactive tracers in biochemistry$xMathematics.$2fast$0(OCoLC)fst01087791
653 00 $aengineering
653 00 $afysische chemie
653 00 $aphysical chemistry
653 00 $abiomedische techniek
653 00 $abiomedical engineering
653 00 $alevenswetenschappen
653 00 $alife sciences
653 00 $ageneeskunde
653 00 $amedicine
653 00 $atoegepaste statistiek
653 00 $aapplied statistics
653 00 $awiskundige modellen
653 00 $amathematical models
653 00 $atoegepaste wiskunde
653 00 $aapplied mathematics
653 00 $amathematische biologie
653 00 $amathematical biology
653 10 $aEngineering (General)
653 10 $aTechniek (algemeen)
655 4 $aElectronic books.
700 1 $aFoster, David,$eauthor.
700 1 $aToffolo, Gianna,$eauthor.
776 08 $iPrint version:$aCobelli, Claudio.$tTracer kinetics in biomedical research.$dNew York : Kluwer Academic, ©2002$z0306464276
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio4239423$zAll EBSCO eBooks
852 8 $blweb$hEBOOKS