MARC Record from marc_columbia

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001 4240780
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006 m o d
007 cr cn|||||||||
008 030120s2001 njua ob 001 0 eng d
010 $z 00063355
035 $a(OCoLC)ocm51480769
035 $a(NNC)4240780
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020 $a0585438889$q(electronic bk.)
020 $a9780585438887$q(electronic bk.)
020 $a9781592591060$q(electronic bk.)
020 $a159259106X$q(electronic bk.)
020 $a9781617372155$q(print)
020 $a1617372153$q(print)
020 $a128082168X
020 $a9781280821684
020 $a9786610821686
020 $a6610821682
020 $z0896038386$q(alk. paper)
020 $z9780896038387$q(alk. paper)
024 7 $a10.1007/978-1-59259-106-0$2doi
035 $a(OCoLC)51480769$z(OCoLC)171563724$z(OCoLC)604065080$z(OCoLC)647880415$z(OCoLC)648272704$z(OCoLC)1001498989$z(OCoLC)1012466691$z(OCoLC)1038447975$z(OCoLC)1039498704$z(OCoLC)1058753367$z(OCoLC)1078847663$z(OCoLC)1086549859$z(OCoLC)1176442610
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050 4 $aRC365$b.P385 2001eb
060 4 $aWL 359$bP297 2001
072 7 $aHEA$x039110$2bisacsh
072 7 $aMED$x056000$2bisacsh
072 7 $aPSAN$2bicssc
072 7 $aPSAN$2thema
082 04 $a616.8/047$221
084 $aXG 8600$2rvk
049 $aZCUA
245 04 $aThe pathogenesis of neurodegenerative disorders /$cedited by Mark P. Mattson.
260 $aTotowa, N.J. :$bHumana Press,$c©2001.
300 $a1 online resource (x, 294 pages) :$billustrations
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $atext file$bPDF$2rda
490 1 $aContemporary neuroscience
504 $aIncludes bibliographical references and index.
505 0 $aMechanisms of neuronal apoptosis and excitotoxicity / Mark P. Mattson -- Oxidative alterations in neuroegenerative diseases / William R. Markesbery, Thomas J. Montine, and Mark A. Lovell -- Parkinson's disease / M.T. Silva and A.H.V. Schapira -- Scope of trinucleotide repeat disorders / Shoji Tsuji -- Mechanisms of neuronal death in huntington's disease / Vassilis E. Koliatsos [and others] -- Cellular and molecular mechanisms underlying synaptic degeneration and neuronal death in alzheimer's disease / Mark P. Mattson, Ward A. Pedersen, and Carsten Culmsee -- Oxidative stress in down syndrome / Rocco C. Iannello and Ismail Kola -- Pathogenesis of amyotrophic lateral sclerosis / Stanley H. Appel and R. Glenn Smith -- Experimental genetics as a tool for understanding pathogenesis of ALS / Philip C. Wong, Donald L. Price, and Jamuna Subramaniam -- Pathognesis of ischemic stroke / Mark P. Mattson and Carsten Culmsee -- Spinal-cord injury / Isabel Klusman and Martin E. Schwab -- Pathognesis of duchenne muscular dystrophy / Edward A. Burgon and Kay E. Davies.
520 $aRecent scientific advances have dramatically expanded our understanding of the molecular, genetic, and environmental factors that either cause or contribute to a wide variety of age-related neurodegenerative disorders. In Pathogenesis of Neurodegenerative Disorders, leading experts detail the cellular and molecular cascades that cause selective degeneration of neuronal populations, and illuminate those factors that are critical to the facilitation or suppression of these neuropathologic processes. Working from studies of human patients, as well as from cell culture and animal models, the authors demonstrate a heretofore unrecognized convergence of the causative pathogenetic mechanisms for many clinically distinct neurological disorders. At center stage are the biochemical and molecular cascades that will ultimately lead to neuronal death-cascades involving oxyradical production, aberrant regulation of cellular ion homeostasis, activation of specific proteases, and activation of a stereotyped sequence of events involving mitochondrial dysfunction. Individual chapters examine how these mechanisms-along with genetic and environmental factors-operate in Alzheimer's and Parkinson's diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke, spinal cord injury, and Duchenne muscular dystrophy. Pioneering and richly insightful, Pathogenesis of Neurodegenerative Disorders offers a critical and integrative summary of the cutting-edge research findings that illuminate the common genetic, cellular, and molecular bases of many neurological disorders today that promise powerful new preventive and treatment approaches in future.
506 $3Use copy$fRestrictions unspecified$2star$5MiAaHDL
533 $aElectronic reproduction.$b[Place of publication not identified] :$cHathiTrust Digital Library,$d2010.$5MiAaHDL
538 $aMaster and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.$uhttp://purl.oclc.org/DLF/benchrepro0212$5MiAaHDL
583 1 $adigitized$c2010$hHathiTrust Digital Library$lcommitted to preserve$2pda$5MiAaHDL
588 0 $aPrint version record.
546 $aEnglish.
650 0 $aNervous system$xDegeneration$xPathogenesis.
650 12 $aNeurodegenerative Diseases$xetiology
650 22 $aNeurodegenerative Diseases$xgenetics
650 7 $aHEALTH & FITNESS$xDiseases$xNervous System (incl. Brain)$2bisacsh
650 7 $aMEDICAL$xNeurology.$2bisacsh
650 7 $aNeurosciences.$2fast$0(OCoLC)fst01036509
650 17 $aMaladies neurodégénératives.$2fmesh
650 17 $aMaladies neurodégénératives héréditaires.$2fmesh
650 7 $aPathogenese$2gnd
650 7 $aNervendegeneration$2gnd
650 7 $aSystème nerveux$xDégénérescence.$2ram
655 4 $aElectronic books.
700 1 $aMattson, Mark Paul.
776 08 $iPrint version:$tPathogenesis of neurodegenerative disorders.$dTotowa, N.J. : Humana Press, ©2001$z0896038386$w(DLC) 00063355$w(OCoLC)44841567
830 0 $aContemporary neuroscience.
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio4240780$zAll EBSCO eBooks
852 8 $blweb$hEBOOKS