MARC Record from marc_columbia

LEADER: 05472cam a22006734a 4500
001 4241151
005 20220723225602.0
006 m o d
007 cr |n|||||||||
008 030616s2001 njua ob 001 0 eng c
010 $z 2001039417
035 $a(OCoLC)ocm52434112
035 $a(NNC)4241151
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020 $a1592591809$q(electronic bk.)
020 $a9781592591800$q(electronic bk.)
020 $z0896038890$q(alk. paper)
020 $z9780896038899$q(alk. paper)
035 $a(OCoLC)52434112$z(OCoLC)81801811$z(OCoLC)232302243$z(OCoLC)320959027$z(OCoLC)642460526$z(OCoLC)964932733$z(OCoLC)967620073$z(OCoLC)1043059895$z(OCoLC)1081216649$z(OCoLC)1087430285$z(OCoLC)1175937150
042 $apcc
050 4 $aRS419.5$b.H54 2002
060 4 $aQV 771$bH638 2002
070 $aQH506$b.M45 v. 190
072 7 $aMED$x023000$2bisacsh
072 7 $aMED$x071000$2bisacsh
072 7 $aMED$x072000$2bisacsh
072 7 $aMED$x058170$2bisacsh
082 04 $a615/.19$221
049 $aZCUA
245 00 $aHigh throughput screening :$bmethods and protocols /$cedited by William P. Janzen.
260 $aTotowa, N.J. :$bHumana Press,$c©2002.
300 $a1 online resource (ix, 265 pages) :$billustrations (some color)
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
490 1 $aMethods in molecular biology ;$vv. 190
504 $aIncludes bibliographical references and index.
505 0 $aDesign and implementation of high throughput screening assays / Ricardo Macarrón -- Configuring radioligand receptor binding assays for HTS using scintillation proximity assay technology / John W. Carpenter -- Homogeneous techniques for monitoring receptor-ligand interactions / James S. Marks -- Comparison of SPA, FRET, and FP for kinase assays / Jinzi J. Wu -- Electrochemiluminescence: a technology evaluation and assay reformatting of the Stat6/P578 protein-peptdie interaction / Robert H. Schweitzer -- Cellular assays in HTS / Patricia Johnston -- Compound library management / James A. Chan -- Compound library management: an overview of an automated system / Wilma W. Keighley -- Natural products or not? How to screen for natural products in the emerging HTS paradigm / Susan P. Manly -- Introduction to screening automation / Steven Hamilton -- Unit automation in high throughput screening / Karl C. Menke -- Fully automated screening systems / Seth Cohen -- Management and maintenance of high throughput screening systems / Barbara Hynd.
520 $aSince its first use in antibiotic research in the 1940s, High Throughput Screening (HTS) has evolved into a major enabling tool and methodology in the discovery of pharmaceutical, chemical, and agricultural compounds. In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wished had been available when they started in HTS, these seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge. By presenting accounts not only of the basic principles underlying HTS technology, but also real-use cases, High Throughput Screening constitutes a highly practical introduction to HTS, even as it also provides sufficient detail to work more productively in today's lead generation laboratories.
650 0 $aHigh throughput screening (Drug development)
650 0 $aPharmaceutical chemistry.
650 12 $aDrug Evaluation, Preclinical$xmethods
650 12 $aHigh-Throughput Screening Assays$xmethods
650 22 $aChemistry, Pharmaceutical
650 6 $aCriblage à haut débit (Développement des médicaments)
650 6 $aChimie pharmaceutique.
650 7 $aMEDICAL$xDrug Guides.$2bisacsh
650 7 $aMEDICAL$xPharmacology.$2bisacsh
650 7 $aMEDICAL$xPharmacy.$2bisacsh
650 7 $aMEDICAL$xNursing$xPharmacology.$2bisacsh
650 7 $aPharmaceutical chemistry.$2fast$0(OCoLC)fst01060115
650 7 $aHigh throughput screening (Drug development)$2fast$0(OCoLC)fst00956496
655 4 $aElectronic books.
700 1 $aJanzen, William P.
776 08 $iPrint version:$tHigh throughput screening.$dTotowa, N.J. : Humana Press, ©2002$z0896038890$w(DLC) 2001039417$w(OCoLC)47521304
830 0 $aMethods in molecular biology (Clifton, N.J.) ;$vv. 190.
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio4241151$zAll EBSCO eBooks
852 8 $blweb$hEBOOKS