| Record ID | marc_columbia/Columbia-extract-20221130-009.mrc:72834592:3147 |
| Source | marc_columbia |
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LEADER: 03147fam a2200445 a 4500
001 4058887
005 20221027025750.0
008 980120s1998 txua b 001 0 eng c
010 $a 98011142
020 $a3540645608
035 $a(OCoLC)501486546
035 $a(OCoLC)ocn501486546
035 $9ANY6081HS
035 $a(NNC)4058887
035 $a4058887
040 $aDNLM/DLC$cDLC$dDLC$dNNC-M$dOrLoB-B
050 00 $aRC269.5$b.G56 1998
060 10 $aQZ 202 G561f 1998
082 00 $a616.99/407$221
100 1 $aGlinsky, Gennadi V.$0http://id.loc.gov/authorities/names/n93802309
245 10 $aFailure of apoptosis and cancer metastasis /$cGennadi V. Glinsky.
260 $aAustin :$bR.G. Landes,$c1998.
300 $a178 pages :$billustrations ;$c24 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
490 1 $aMedical intelligence unit
504 $aIncludes bibliographical references and index.
505 00 $g1.$tCell Adhesion Cascade as a Multicomponent and Multistep Process with Multiple Decision Forks for Death and Life --$g2.$tApoptosis and Metastasis: Failure of Apoptosis in Metastatic Cancer Cells as a Key Factor of Metastatic Disease --$g3.$tApoptosis Resistance of Metastatic Cancer Cells Is Associated with Deficiency of Apoptosis Execution Mechanisms --$g4.$tA Hypothesis for Telomere-Dependent Control of Apoptosis --$g5.$tInhibition of Homotypic Cancer Cell Aggregation and Colony Formation in Agarose of Metastatic Human Cancer Cells by Synthetic Glycoamine Analogs --$g6.$tInhibition of Human Breast Cancer Metastasis in Nude Mice by Synthetic Glycoamines.
520 $aThis book summarizes recent reports on adhesion-dependent regulation of apoptosis. The author discusses data indicating that highly metastatic cancer cells exhibit a superior survival ability and resistance to apoptosis induced by diverse external signals. He also shows that increased survival of metastatic cancer cells compared to nonmetastatic or poorly metastatic cells is associated with their enhanced galectin-mediated homotypic aggregation and dysfunction of adhesion-dependent regulation of apoptosis.
520 8 $aProfound deficiency of two major apoptosis execution mechanisms has been identified as a main characteristic of apoptosis failure in metastatic cancer cells.
650 0 $aMetastasis.$0http://id.loc.gov/authorities/subjects/sh85084296
650 0 $aApoptosis.$0http://id.loc.gov/authorities/subjects/sh91000743
650 0 $aCell adhesion.$0http://id.loc.gov/authorities/subjects/sh85021639
650 12 $aNeoplasm Metastasis$xphysiopathology.$0https://id.nlm.nih.gov/mesh/D009362Q000503
650 22 $aNeoplasm Metastasis$xprevention & control.$0https://id.nlm.nih.gov/mesh/D009362Q000517
650 22 $aApoptosis$xphysiology.$0https://id.nlm.nih.gov/mesh/D017209Q000502
650 22 $aCell Adhesion$xphysiology.$0https://id.nlm.nih.gov/mesh/D002448Q000502
650 22 $aCell Survival$xphysiology.$0https://id.nlm.nih.gov/mesh/D002470Q000502
830 0 $aMedical intelligence unit.$0http://id.loc.gov/authorities/names/n2001021011
852 00 $boff,hsl$hRC269.5$i.G56 1998