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020 $a1584886420
020 $a9781584886426
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050 00 $aQH324.2$b.A46 2007
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082 00 $a570.285$222
100 1 $aAlon, Uri,$d1969-$0http://id.loc.gov/authorities/names/no2006076097
245 13 $aAn introduction to systems biology :$bdesign principles of biological circuits /$cUri Alon.
260 $aBoca Raton, FL :$bChapman & Hall/CRC,$c[2007], ©2007.
300 $axvi, 301 pages, 4 unnumbered pages of plates :$billustrations (some color) ;$c26 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
490 1 $aChapman & Hall/CRC mathematical and computational biology series ;$v10
504 $aIncludes bibliographical references (p. 271-293) and index.
505 00 $gCh. 1.$tIntroduction --$gCh. 2.$tTranscription networks : basic concepts --$gCh. 3.$tAutoregulation : a network motif --$gCh. 4.$tThe feed-forward loop network motif --$gCh. 5.$tTemporal programs and the global structure of transcription networks --$gCh. 6.$tNetwork motifs in developmental, signal transduction, and neuronal networks --$gCh. 7.$tRobustness of protein circuits : the example of bacterial chemotaxis --$gCh. 8.$tRobust patterning in development --$gCh. 9.$tKinetic proofreading --$gCh. 10.$tOptimal gene circuit design --$gCh. 11.$tDemand rules for gene regulation --$gCh. 12.$tEpilogue : simplicity in biology --$gApp. A.$tThe input function of a gene : Michaelis-Menten and Hill equations --$gApp. B.$tMulti-dimensional input functions --$gApp. C.$tGraph properties of transcription networks --$gApp. D.$tCell-cell variability in gene expression.
520 1 $a"An Introduction to Systems Biology: Design Principles of Biological Circuits builds a foundation for the intuitive understanding of general principles in biology. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models."--BOOK JACKET.
650 0 $aComputational biology.$0http://id.loc.gov/authorities/subjects/sh2003008355
650 0 $aBiological systems$xMathematical models.$0http://id.loc.gov/authorities/subjects/sh2009117079
650 2 $aSystems Biology$xmethods.$0https://id.nlm.nih.gov/mesh/D049490Q000379
830 0 $aChapman and Hall/CRC mathematical & computational biology series ;$v10.$0http://id.loc.gov/authorities/names/n2005083011
856 42 $3Publisher description$uhttp://www.loc.gov/catdir/enhancements/fy0654/2005056902-d.html
852 00 $bsci$hQH324.2$i.A46 2007
852 00 $bsci$hQH324.2$i.A46 2007