MARC Record from marc_columbia

LEADER: 03005cam a22004095a 4500
001 6879301
005 20221122055141.0
008 080317s2008 njua b 001 0 eng
015 $aGBA854923$2bnb
016 7 $a014584497$2Uk
020 $a9781934115299 (hbk.)
020 $a1934115290 (hbk.)
035 $a(OCoLC)ocn209332297
035 $a(OCoLC)209332297
035 $a(NNC)6879301
035 $a6879301
040 $aUKM$cUKM$dYDXCP$dBAKER$dBTCTA$dNNC-M$dOrLoB-B
050 0 $aRC271.R3$bS46 2008
082 04 $a616.994061$222
245 00 $aSensitization of cancer cells for chemo/immuno/radio-therapy /$cedited by Benjamin Bonavida.
260 $aTotowa, N.J. :$bHumana ;$aLondon :$bSpringer [distributor],$c2008.
300 $axxi, 419 pages :$billustrations (some color) ;$c26 cm.
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
490 1 $aCancer drug discovery and development
504 $aIncludes bibliographical references and index.
520 1 $a"Cancer chemotherapy can be traced back to the 1940 s and since then the world has witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can be treated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority of cytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. This book also introduces several of the current approaches that have been developed by established investigators in the field that are aimed at overcoming resistance. This book is the first that compiles studies on tumor cell sensitization and is useful for students, scientists, clinicians and pharmaceutical companies."--BOOK JACKET.
650 0 $aRadiation-sensitizing agents.$0http://id.loc.gov/authorities/subjects/sh85110359
650 0 $aDrug resistance in cancer cells.$0http://id.loc.gov/authorities/subjects/sh90005205
650 0 $aAntineoplastic agents$xEffectiveness.
650 12 $aRadiation-Sensitizing Agents.$0https://id.nlm.nih.gov/mesh/D011838
650 22 $aDrug Resistance.$0https://id.nlm.nih.gov/mesh/D004351
650 22 $aAntineoplastic Agents.$0https://id.nlm.nih.gov/mesh/D000970
650 22 $aNeoplasms$xradiotherapy.$0https://id.nlm.nih.gov/mesh/D009369Q000532
700 1 $aBonavida, Benjamin.$0http://id.loc.gov/authorities/names/n85263154
830 0 $aCancer drug discovery and development.$0http://id.loc.gov/authorities/names/n88538383
852 00 $boff,hsl$hRC271.R3$iS46 2008