MARC Record from marc_columbia

LEADER: 03893cam a2200385Ia 4500
001 7034894
005 20221130204118.0
008 080709t20092009nyu b 001 0 eng d
020 $a9781402089060
020 $a1402089066
035 $a(OCoLC)ocn233934347
035 $a(OCoLC)233934347
035 $a(NNC)7034894
035 $a7034894
040 $aBTCTA$cBTCTA$dBAKER$dYDXCP$dLTL$dOrLoB-B
050 4 $aR853.C55$bG38 2009
060 4 $aW 20.5$bG265i 2009
100 1 $aGauch, Ronald R.$0http://id.loc.gov/authorities/names/n00004472
245 10 $aIt's great! oops, no it isn't :$bwhy clinical research can't guarantee the right medical answers /$cRonald R. Gauch.
246 30 $aWhy clinical research can't guarantee the right medical answers
260 $a[New York, N.Y.] :$bSpringer Science + Business Media,$c[2009], ©2009.
300 $axiii, 298 pages ;$c25 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
504 $aIncludes bibliographical references (p. 255-281) and index.
505 00 $gPt. I.$tMedical Research Explained -- $g1.$tMedical Research - Searching for Answers -- $g2.$tThe Case-Control Method - Looking Backwards -- $g3.$tThe Cohort Study - Watchful Waiting -- $g4.$tThe Clinical Trial - The Gold Standard -- $g5.$tComparing the Methods - Qualitative Differences -- $gPt. II.$tUnderstanding the Clinical Trial -- $g6.$tThe Protocol - The Guiding Light -- $g7.$tThe Control Group - Leveling the Playing Field -- $g8.$tMeasurements - They're Never Exact -- $g9.$tBias Control - A Closer Look at Blinding and Randomization -- $g10.$tUtility - Are Clinical Trial Results Useful? -- $g11.$tResearch Discrimination - Inadequately Tested Populations -- $g12.$tSeven Deadly Flaws - The Clinical Trials' Achilles' Heel -- $gPt. III.$tTools of the Trade -- $g13.$tStatistics - Was the Finding Significant? -- $g14.$tAnalysis Issues - A Lot of Choices -- $g15.$tMeta Analysis - An Alternative to Large Trials -- $gPt. IV.$tThe Real World -- $g16.$tResearch Results That Clashed - What's the Right Answer? -- $g17.$tHormone Replacement Therapy - The Silver Bullet That Misfired -- $g18.$tPublishing - Getting the Word Out to Doctors -- $g19.$tThe Public Forum - Sharing the News with the Public -- $g20.$tProduct Development - Getting Discoveries to the Market -- $g20.$tProduct Development - Getting Discoveries to the Market -- $g21.$tMedical Innovations - Regulators, Resources and Results -- $g22.$tScience and Politics - A Troubling Mixture -- $g22.$tScience and Politics - A Troubling Mixture -- $g23.$tResearch Misconduct - Irresistible Temptation -- $g24.$tPostmarketing Surveillance - An Imperfect System -- $g25.$tRegulatory Reform - Changes Needed -- $g26.$tJourney's End - A Call for Action.
520 1 $a"This book dissects medical research methodology and through a penetrating inquiry into its triumphs and tragedies explains why correct answers are so hard to achieve. What emerges from this inquiry is the unexpected and stunning conclusion that medical researchers can never be sure that they've ended up with a truthful answer. In IT'S GREAT! readers learn why the quest for knowledge through clinical trials is fraught with problems that even the best researchers cannot overcome."--BOOK JACKET.
650 0 $aClinical medicine$xResearch$xMethodology.
650 0 $aClinical trials.$0http://id.loc.gov/authorities/subjects/sh85027069
650 0 $aMedicine$xResearch$xMethodology.$0http://id.loc.gov/authorities/subjects/sh2008107671
650 12 $aClinical Trials as Topic$xmethods.$0https://id.nlm.nih.gov/mesh/D002986Q000379
650 12 $aBiomedical Research$xmethods.$0https://id.nlm.nih.gov/mesh/D035843Q000379
650 12 $aResearch Design.$0https://id.nlm.nih.gov/mesh/D012107
650 22 $aStatistics as Topic$xmethods.$0https://id.nlm.nih.gov/mesh/D013223Q000379
852 00 $boff,hsl$hR853.C55$iG38 2009