MARC Record from marc_columbia

LEADER: 13089cam a2200409 a 4500
001 7934442
005 20221201045414.0
008 100604t20112011fluaf b 001 0 eng
010 $a 2010021868
015 $aGBB049918$2bnb
016 7 $a015529861$2Uk
019 $a226357472$a619611731
020 $a9781420080209 (hardcover : alk. paper)
020 $a1420080202 (hardcover : alk. paper)
035 $a(OCoLC)ocn639520907
035 $a(OCoLC)639520907$z(OCoLC)226357472$z(OCoLC)619611731
035 $a(NNC)7934442
035 $a7934442
040 $aDLC$cDLC$dYDX$dYDXCP$dUKM$dBTCTA$dBAKER$dNNC-M$dOrLoB-B
050 00 $aRA1242.H87$bJ48 2011
082 00 $a615.9/5$222
245 00 $aJet fuel toxicology /$cedited by Mark L. Witten, Errol Zeiger, Glenn D. Ritchie.
260 $aBoca Raton, FL :$bCRC Press,$c[2011], ©2011.
300 $axiii, 324 pages, 8 unnumbered pages of plates :$billustrations (some color) ;$c25 cm
336 $atext$btxt$2rdacontent
337 $aunmediated$bn$2rdamedia
504 $aIncludes bibliographical references and index.
505 00 $gChapter 1.$tAir Force-Related Jet Fuel Toxicology Research (1991-2010) -- $tIntroduction -- $tJet Fuel Use by the Military -- $tJP-8 Exposures and Health Concerns -- $t1996 Report by the National Research Council (NRC): Recommendations for JP-8 Toxicology Research -- $tAFOSR JP-8 Toxicology Program: Research Thrusts and Approaches -- $tInhalation of JP-8 Aerosols, Lung Damage, and Immune System Suppression -- $tDermal Application of JP-8 and Immune System Suppression -- $tMechanisms and Inhibitors of JP-8-induced Immune System Suppression -- $tMechanisms and Inhibitors of JP-8-induced Cellular Toxicity in Lung, Immune, and Skin Cells -- $tAir Force (AF) Concern and Response to Potential Health Effects of JP-8: The AF JP-8 Acute Human Study -- $t2003 Report by the National Research Council: Recommendation for Further Research on JP-8 Toxicology -- $tResponse of AFOSR-Funded JP-8 Toxicology Research to the 2003 NRC Recommendations (Items 1 to 8) -- $tCommentary on Jet Fuel Toxicity and Compliance with PEL Standards and Exposure Safeguards -- $tToxicology and Future Jet Fuels -- $tAFOSR Jet Fuel Toxicology Program: Summation and Conclusion -- $tReferences -- $gChapter 2.$tJet Fuel Composition /$rWalter J. Kozumbo -- $tJet Fuel Composition: JP-8, Jet A, and Jet A-1 -- $tAlternative (Non-Petroleum) Jet Fuels -- $tReferences -- $gChapter 3.$tThe Toxicity and Underlying Mechanism of Jet Propulsion Fuel-8 on the Respiratory System /$rTim Edwards and Simon S. Wong -- $tIntroduction -- $tMorphological Alterations -- $tNeuro-Immunological Responses -- $tCellular Toxicity -- $tProteomic and Genomic Changes -- $tSynthetic Jet Fuel S-8 -- $tSummary -- $tReferences -- $gChapter 4.$tNeurotoxicological and Neurobehavioral Effects from Exposure to Jet Fuels /$rMark L. Witten -- $tIntroduction -- $tJet Fuel Exposure Studies in Humans and Animals -- $tAnimal Studies -- $tCognitive and Neurobehavioral Studies in Animals -- $tOcular and Dermal System Toxicity in Animals -- $tPeripheral Auditory System Effects in Animals -- $tHuman Studies -- $tCognitive and Neurobehavioral Studies in Humans -- $tOcular System Effects in Humans -- $tPeripheral and Central Auditory System Effects in Humans -- $tVestibular System Effects in Humans -- $tIn Vitro Studies -- $tNeurotoxicity from Exposure to Jet Fuel Exhaust -- $tConclusions -- $tReferences -- $gChapter 5.$tDifferential Protein Expression Following JP-8 Jet Fuel Exposure /$rGlenn D. Ritchie and Frank A. Witzmann -- $tIntroduction -- $tThe 2-DE Gel-Based Proteomic Approach -- $tElectrophoresis, Image Analysis, and Protein Identification -- $tShort-Term JP-8 Aerosol Exposure -- $tLung Proteomics -- $tModerate Concentration/Duration JP-8 Exposures -- $tLung Proteomics -- $tRenal Proteomics -- $tEffects of Long-Term JP-8 Vapor Exposure -- $tTestis Proteomics -- $tPersisting Effects of JP-8 Vapor Exposure, Following a Period of Recovery -- $tLabel-Free Quantitative Mass Spectrometry (LFQMS): Alternative to 2-DE -- $tOverall Conclusions -- $tReferences -- $gChapter 6.$tImmune Modulation by Dermal Exposure to Jet Fuel /$rMark L. Witten and Gerardo Ramos -- $tIntroduction -- $tImmune Modulation Following Dermal Application of Jet Fuel -- $tMechanisms Underlying Jet-Fuel-Induced Immunotoxicity -- $tCytokines and Immune-Modulatory Factors Activate Jet Fuel-Induced Immune Suppression -- $tThe Aromatic Compounds in Jet Fuel Drive Immune Suppression -- $tAre Humans at Risk Following Dermal Exposure to Jet Fuel? -- $tImmune Modulation by Other Routes of Exposure -- $tSummary and Conclusions -- $tAcknowledgments -- $tReferences -- $gChapter 7.$tAbsorption, Penetration, and Cutaneous Toxicity of Jet Fuels and Hydrocarbon Components /$rStephen E. Ullrich, James E. Riviere and Alfred O. Inman -- $tIntroduction -- $tIn Vitro Studies -- $tIn Vivo Studies -- $tConclusion -- $tReferences -- $gChapter 8.$tMethods of Assessing Skin Irritation and Sensitization of Jet Fuels /$rNancy Monteiro-Riviere, R. Jayachandra Babu and Ram Patlolla -- $tIntroduction -- $tBiophysical Methods of Assessing Skin Irritation of Jet Fuels -- $tBiochemical Methods of Assessing Skin Irritation of Jet Fuels -- $tBiomarker Measurements in Animals -- $tBiomarker Measurements in the Cultured Skin Tissue -- $tDermal Microdialysis of Neuropeptides and Cytokines -- $tSkin Sensitization and Immune Suppression of Jet Fuels -- $tConclusions -- $tReferences -- $gChapter 9.$tUnderstanding Systemic and Local Toxicity of JP-8 after Cutaneous Exposures /$rMandip Singh, James N. McDougal and James V. Rogers -- $tIntroduction -- $tSystemic Toxicity -- $tIn Vitro Skin Penetration Studies -- $tRoute-to-Route Extrapolation -- $tLocal Toxicity -- $tSkin Sensitization -- $tSkin Cancer -- $tSkin Irritation -- $tGene Expression -- $tBasal Gene Expression in the Rat -- $tBrief Exposure Studies with Rats -- $tComparisons of JP-8 with Other Chemicals -- $tBrief Exposure Studies with Human Volunteers -- $tConclusions -- $tReferences -- $gChapter 10.$tThe Effects of Aerosolized JP-8 Jet Fuel Exposure on the Immune System: A Review /$rRichard Simman -- $tOverview -- $tIntroduction -- $tReview of the Effects on the Immune System -- $tGeneral Effects -- $tEffects on Cellular Immunity -- $tIL-10 and Prostaglandin E2 Secretion -- $tNew Exposure System Effects -- $tThe Effects of Jet Fuel Source -- $tGenomic Analyses -- $tRemedial Effects of Substance P Therapy -- $tGeneral Effects -- $tPre or Post Exposure Effects -- $tDose Responses -- $tPotential Real-World Consequences -- $tIn Utero Exposures -- $tInfluenza -- $tCancer -- $tOther -- $tAcknowledgments -- $tReferences -- $gChapter 11.$tThe Involvement of Poly(ADP-ribosyl)ation in Defense against JP-8 Jet Fuel and Other Chemical Toxicants /$rDavid T. Harris, Luis A. Espinoza, Aria Attia and Eric M. Brandon -- $tIntroduction -- $tCell Type Specificity of JP-8 Toxicity -- $tJP-8-Induced Changes in Gene Expression Profiles of Human Cells -- $tTranscriptional Profiling of the JP-8 Response in Lymphocytes -- $tTranscriptional Profiling of the JP-8 Response in Keratinocytes -- $tTranscriptional Profiling of the Rat Lung Response to JP-8 -- $tPoly(ADP-ribose) Polymerase-1 Is Activated by JP-8 in Pulmonary Cells -- $tEffects of JP-8 on Cell Viability of Respiratory Epithelial Cells -- $tEffects of JP-8 on Phosphorylation and Degradation of IxBa in Epithelial Cells -- $tJP-8 Prolongs NF-icB Activation of Pulmonary Cells -- $tEffect of JP-8 on the Expression of Proinflammatory Mediators -- $tJP-8 Induces PARP-1 Activation -- $tConclusions -- $tReferences -- $gChapter 12.$tEvaluation of Methods Used to Generate and Characterize Jet Fuel Vapor and Aerosol for Inhalation Toxicology Studies /$rMark E. Smulson, Raphael T. Tremblay and Sheppard A. Martin -- $tIntroduction -- $tIssues Associated with the Generation of a Jet Fuel Atmosphere -- $tGeneration of a Jet Fuel Atmosphere -- $tHeated Tube -- $tBubbler System -- $tAtomizers -- $tUltrasonic Nebulizer -- $tConclusions on Generation Systems -- $tChamber Atmosphere Characterizations -- $tGas-Phase Characterization -- $tTotal Hydrocarbon (THC) Analyzer -- $tGas Chromatography-Flame Ionization Detection -- $tInfrared Spectroscopy -- $tAdsorbent Tubes -- $tAerosol Characterization -- $tFilters -- $tAdsorbent Tube -- $tOptical Aerosol Measurement -- $tAerosol Size Determination -- $tConclusions -- $tReferences -- $gChapter 13.$tGenetic Damage in the Blood and Bone Marrow of Mice Treated with JP-8 Jet Fuel /$rJeffrey W. Fisher -- $tIntroduction -- $tMaterials and Methods -- $tJP-8 Treatment(s) and Tissue Collection Schedule(s) for Group 2 Mice -- $tResults -- $tDiscussion -- $tAcknowledgments -- $tReferences -- $gChapter 14.$tComputational Analyses of JP-8 Fuel Droplet and Vapor Depositions in Human Upper Airway Models /$rVijayalaxmi and Clement Kleinstreuer -- $tIntroduction -- $tTheory -- $tAirway Geometries -- $tGoverning Equations -- $tAirflow and Heat Transfer -- $tTransport of Micro-size Droplets -- $tDroplet Evaporation -- $tMass Transfer of Vapor or Nanoparticles -- $tDeposition Parameters -- $tNumerical Method -- $tResults -- $tModel Validations -- $tAirflow Structures -- $tNasal Flow --
505 80 $tOral-Tracheobronchial Flow -- $tVapor Deposition -- $tNasal Deposition -- $tOral and Tracheobronchial Deposition -- $tImpact of Airway Wall Absorption Parameter IC -- $tDroplet Dynamics -- $tSingle-Component Droplet Vaporization and Deposition -- $tAirway Geometry Effects -- $tDevelopment of Droplet Vaporization Model and JP-8 Fuel Surrogate -- $tTransport and Deposition of Multicomponent Droplets -- $tDeposition Comparisons between Vapor (Nanoparticles) and Micron Particles (Droplets) -- $tConclusions -- $tAcknowledgments -- $tReferences -- $gChapter 15.$tHuman Exposure to Jet Propellant-8 /$rZhe Zhang and Raymond H. Tu -- $tIntroduction -- $tOccupational Exposure to JP-8 -- $tJP-8 Exposure Assessment -- $tAmbient Air Measurements -- $tDermal Estimation of Exposure -- $tInhalation Estimation of Exposure -- $tHuman Health Effects of Exposure -- $tConclusions -- $tReferences.
520 1 $a"Due to its widespread use, jet fuel is thought to be the largest toxicant exposure risk for U.S. Armed Services personnel. Taking a proactive approach to the potential dangers of repeated human exposure to hydrocarbon fuels, the Air Force Office of Scientific Research (AFOSR) sponsored a number of research projects during the last 20 years investigating health effects resulting from specific exposure to JP-8 (Jet Propellant-8)." "Jet Fuel Toxicology summarizes the newest and most important results of these extensive research programs carried out by hydrocarbon fuel research groups throughout the United States. Each book chapter highlights one specific research area from the many topical areas comprising jet fuel toxicology. After examining the contents and general action of JP-8, the book looks at how the fuel affects various body functions highlighted by:" "-Effects of daily inhalation on the respiratory system" "-Acute and long-term neurotoxicological and neurobehavioral effects" "-Both local and systemic toxicity following exposure through the skin" "-Immunotoxicity from pulmonary and dermal exposures" "-Genetic damage, as evidenced in studies of the blood and bone marrow of mice" "In all, the book considers 13 major toxicology areas of study, the results of which will enable all of the hydrocarbon industry to make fuel choices that more carefully consider possible human health risks." "Perhaps even more importantly, the book profoundly demonstrates how unfortunate lessons from the following major chemical exposure scenarios of the past must not be lost in the ongoing protection of both military personnel and civilians:" "-Agent Orange exposures during the Vietnam War" "-Multiple chemical/stressor exposures, including multiple fuels and solvents, during the Persian Gulf Wars" "-Chemical exposures, including Jet-A fuel, during the 9/11 World Trade Center Disaster" "-Hydrocarbon/oil dispersing compound exposures during the Gulf of Mexico Oil Spill Crisis of 2010" "For example, based on data contained in this book, the Air Force now removes female personnel from any exposure to jet fuel during their pregnancies and has reduced permissible exposure levels to jet fuel for all military and associated civilian staff. Ultimately, this book can serve as a template for managing future toxicological issues for both international armed forces and those corporations willing to learn from these important lessons."--BOOK JACKET.
650 0 $aJet planes$xFuel$xToxicology.
650 12 $aJP8 aviation fuel.
650 22 $aToxicology.$0https://id.nlm.nih.gov/mesh/D014116
700 1 $aWitten, Mark L.$q(Mark Lee),$d1953-$0http://id.loc.gov/authorities/names/n84108362
700 1 $aZeiger, Errol.$0http://id.loc.gov/authorities/names/n96078462
700 1 $aRitchie, Glenn David.$0http://id.loc.gov/authorities/names/n2010035927
852 00 $boff,hsl$hRA1242.H87$iJ48 2011