MARC Record from marc_columbia

LEADER: 03889cam a2200349Ia 4500
001 9187137
005 20120220192658.0
008 111230s2011 dcua b 000 0 eng
020 $a9780309219396
020 $a0309219396
035 $a(OCoLC)ocn769822338
035 $a(OCoLC)769822338
035 $a(NNC)9187137
040 $aNRZ$cNRZ$dOCLCQ
090 $aRA643$b.S35 2011.
110 2 $aInstitute of Medicine (U.S.).$bBoard on Global Health.
245 14 $aThe science and applications of synthetic and systems biology :$bworkshop summary /$cEileen R. Choffnes, David A. Relman, and Leslie Pray, rapporteurs ; Forum on Microbial Threats, Board on Global Health, Institute of Medicine of the National Academies.
260 $aWashington, D.C. :$bNational Academy Press,$cc2011.
300 $axxii, 548 p. :$bill. (some col.) ;$c23 cm.
504 $aIncludes bibliographical references.
505 1 $aWorkshop overview -- Contributed manuscripts -- Synthetic biology: applications come of age -- The genome as the unit of engineering -- Synthetic biology: a new generation of biofilm biosensors -- Synthetic biology and the art of biosensor design -- Systems analysis of adaptive immunity by utilization of high-throughput technologies -- The new science of sociomicrobiology and the realm of syntheticand systems ecology -- Creation of a bacterial cell controlled by a chemically synthesized genome -- Synthetic biology "from scratch" -- Manufacturing molecules through metabolic engineering -- Novel approaches to combat biofilm drug tolerance -- Next-generation synthetic gene networks -- Engineering scalable biological systems -- Metabolic systems biology -- Systems vaccinology -- Solving vaccine mysteries: a systems biology perspective -- Systems biology of vaccination for seasonal influenza in humans -- Synthetic systems as microbial threats: predictability of loss-of-function mutations in engineered systems -- Isoprenoid pathway optimization for taxol precursor overproduction -- Programming cells: towards an automated 'genetic compiler' -- Prokaryotic gene clusters: a rich toolbox for synthetic biology -- The silicon trypanosome.
520 $a"Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary"--Publisher's description.
530 $aAlso available online.
650 0 $aDisease susceptibility$xGenetic aspects.
650 0 $aMolecular genetics.
650 0 $aGenetic engineering.
700 1 $aChoffnes, Eileen R.
700 1 $aRelman, David A.
700 1 $aPray, Leslie A.
710 2 $aInstitute of Medicine (U.S.).$bBoard on Global Health.
856 41 $3National Academies Press$uhttp://www.nap.edu/catalog.php?record_id=13239
852 00 $boff,sci$hRA643$i.I67 2011g