MARC Record from marc_columbia

LEADER: 06191cam a2200745Ii 4500
001 11134262
005 20210302172958.0
006 m o d
007 cr cnu|||unuuu
008 141118s2015 ne a ob 001 0 eng d
035 $a(OCoLC)ocn895772596
035 $a(NNC)11134262
040 $aN$T$beng$erda$epn$cN$T$dEBLCP$dN$T$dZCU$dOPELS$dOCLCF$dMYG$dOCLCQ$dUKMGB$dYDXCP$dYDX$dMERER$dOCLCO$dOCLCQ$dU3W$dD6H$dCHVBK$dAU@$dWYU$dCUY$dLOA$dOCLCQ$dUSU$dMERUC$dOCLCO$dICG$dOCLCO$dK6U$dCOCUF$dVT2$dDKC$dFEM$dOCLCQ$dLQU$dOCLCQ$dWURST$dOCLCA
016 7 $a016965687$2Uk
016 7 $a016963762$2Uk
016 7 $a016965687
016 7 $a016963762
019 $a897881152$a898418256$a907378542$a968002748$a969083890$a992488055$a1066623932$a1088968408$a1105174703$a1105561026$a1228609309
020 $a9780128005644$q(electronic bk.)
020 $a0128005645$q(electronic bk.)
020 $z9780128005637
020 $z0128005637
035 $a(OCoLC)895772596$z(OCoLC)897881152$z(OCoLC)898418256$z(OCoLC)907378542$z(OCoLC)968002748$z(OCoLC)969083890$z(OCoLC)992488055$z(OCoLC)1066623932$z(OCoLC)1088968408$z(OCoLC)1105174703$z(OCoLC)1105561026$z(OCoLC)1228609309
037 $a673886869610483474$bTotalBoox$fEbook only$nwww.totalboox.com
050 4 $aRB155.8
060 4 $a2015 A-003
060 4 $aQU 560
072 7 $aMED$x071000$2bisacsh
082 04 $a615.8/95$223
049 $aZCUA
245 00 $aTranslating gene therapy to the clinic :$btechniques and approaches /$cedited by Jeffrey Laurence, Michael Franklin.
264 1 $aAmsterdam :$bAcademic Press, an imprint of Elsevier,$c[2015]
264 4 $c©2015
300 $a1 online resource :$bcolor illustrations.
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $atext file$2rda
490 1 $aAdvances in translational research
588 0 $aOnline resource; title from PDF title page (Ebsco, viewed Dec. 18, 2014).
504 $aIncludes bibliographical references and index.
520 $aTranslating Gene Therapy to the Clinic, edited by Dr. Jeffrey Laurence and Michael Franklin, follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme.
505 0 $aFront Cover; Translating Gene Therapy to the Clinic: Techniques and Approaches; Copyright; Contents; Preface; REFERENCES; About the Editors; Contributors; Chapter 1 -- Translating Genome Engineering to Survival; 1.1 ORIGINS; 1.2 SYNCHRONICITY OF DISCOVERIES; 1.3 GENE ADDITION; 1.4 FROM GENE ADDITION TO GENE EDITING; 1.5 THERAPY FOR GENETIC DISORDERS; 1.6 ROADMAP TO THE FUTURE; CONFLICT OF INTEREST; ACKNOWLEDGMENTS; REFERENCES; Chapter 2 -- Pluripotent Stem Cells and Gene Therapy; 2.1 GENETIC APPROACHES TO PLURIPOTENCY; 2.2 TRANSCRIPTION FACTORS IMPORTANT FOR REPROGRAMMING TO PLURIPOTENCY.
505 8 $a2.3 METHODS FOR GENETIC REPROGRAMMING2.4 CLINICAL TRANSLATION OF IPSCS; 2.5 CONCLUSION; REFERENCES; Chapter 3 -- Genome Engineering for Therapeutic Applications; 3.1 INTRODUCTION; 3.2 CUSTOMIZABLE DNA-TARGETING PROTEINS; 3.3 GENOME EDITING WITH ENGINEERED NUCLEASES; 3.4 SYNTHETIC TRANSCRIPTION FACTORS FOR THERAPEUTIC APPLICATIONS; 3.5 CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Chapter 4 -- Immune System Obstacles to In vivo Gene Transfer with Adeno-Associated Virus Vectors; 4.1 INTRODUCTION; 4.2 AAV VECTORS; 4.3 INNATE IMMUNITY IN AAV GENE TRANSFER; 4.4 T-CELL RESPONSES TO VECTORS.
505 8 $a4.5 HUMORAL IMMUNITY4.6 CONCLUSIONS; ACKNOWLEDGMENT; REFERENCES; Chapter 5 -- Risks of Insertional Mutagenesis by DNA Transposons in Cancer Gene Therapy; 5.1 INSERTIONAL MUTAGENESIS-THE DOWNSIDE OF GENE THERAPY?; 5.2 SLEEPING BEAUTY TRANSPOSON/TRANSPOSASE SYSTEM ADAPTED FOR GENE THERAPY; 5.3 PLASTICITY OF GENOMES AND GENE EXPRESSION IN HUMANS; 5.4 TRANSPOSON-MEDIATED GENE THERAPY IN THE CLINIC; 5.5 CONCLUSIONS; ACKNOWLEDGMENT; REFERENCES; Chapter 6 -- Arthritis Gene Therapy: A Brief History and Perspective; 6.1 INTRODUCTION; 6.2 CONCEPTION AND STRATEGIES; 6.3 TECHNOLOGY DEVELOPMENT.
505 8 $a6.4 UNRESOLVED ISSUES6.5 CLINICAL TRIALS; 6.6 VETERINARY APPLICATIONS; 6.7 OTHER APPLICATIONS OF INTRA-ARTICULAR GENE THERAPY; 6.8 COMMERCIALIZATION; 6.9 PERSPECTIVES; ACKNOWLEDGMENTS; REFERENCES; Chapter 7 -- Type 1 Diabetes Mellitus: Immune Modulation as a Prerequisite for Successful Gene Therapy Strategies; 7.1 INTRODUCTION; 7.2 EFFECTIVE IMMUNE THERAPY/MODULATION: A PREREQUISITE FOR SUCCESSFUL GENE THERAPY OF TYPE 1 DIABETES; 7.3 TARGETED ISLET ANTIGEN RECOGNITION AND ANTIGEN-BASED THERAPIES; 7.4 BROAD IMMUNOSUPPRESSIVE THERAPIES; 7.5 IMMUNOTHERAPIES THAT TARGET EVENTS IN T CELL RESPONSE.
650 0 $aGene therapy.
650 12 $aGenetic Therapy$xmethods.
650 22 $aTranslational Medical Research.
650 7 $aMEDICAL$xPharmacology.$2bisacsh
650 7 $aGene therapy.$2fast$0(OCoLC)fst00939638
653 00 $agentherapie
653 00 $agene therapy
653 00 $ageneeskunde
653 00 $amedicine
653 10 $aMedicine (General)
653 10 $aGeneeskunde (algemeen)
655 0 $aElectronic book.
655 4 $aElectronic books.
700 1 $aLaurence, Jeffrey,$eeditor.
700 1 $aFranklin, Michael,$eeditor.
776 08 $iPrint version:$tTranslating gene therapy to the clinic.$d[S.l.] : Elsevier Academic Press, 2015$z0128005637$z9780128005637$w(OCoLC)884300585
830 0 $aAdvances in translational research.
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio11134262$zAll EBSCO eBooks
852 8 $blweb$hEBOOKS