MARC Record from marc_columbia

LEADER: 05218cam a2200589Ii 4500
001 12335740
005 20190310094741.0
006 m o d
007 cr cnu|||unuuu
008 160615s2016 enk ob 001 0 eng d
019 $a951978198
020 $a9781782628071$q(electronic bk.)
020 $a178262807X$q(electronic bk.)
020 $a9781523104772$q(electronic bk.)
020 $a1523104775$q(electronic bk.)
020 $z9781782628033
020 $a1782628037
020 $a9781782628033
035 $a(OCoLC)ocn951749409
035 $a(NNC)12335740
035 $a(OCoLC)951749409$z(OCoLC)951978198
040 $aN$T$beng$erda$epn$cN$T$dIDEBK$dYDXCP$dN$T$dEBLCP$dUIU$dUKRSC$dKNOVL$dSTF$dOCLCQ$dOCLCQ$dCOO$dLIP$dOCLCQ$dU3G$dSNK$dDKU$dAUW$dINTCL$dBTN$dIGB$dD6H$dVTS$dRRP$dG3B$dLVT$dS8J$dS9I
050 4 $aRA648$b.C545 2016
072 7 $aMED$x071000$2bisacsh
082 04 $a615.9$223
245 00 $aChemical warfare toxicology.$nVolume 2,$pManagement of poisoning /$cedited by Franz Worek, John Jenner, and Horst Thiermann.
246 30 $aManagement of poisoning
264 1 $aCambridge, UK :$bRoyal Society of Chemistry,$c2016.
300 $a1 online resource (xx, 325 pages).
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
347 $adata file$2rda
490 1 $aIssues in toxicology$x1757-7179$vno. 27
588 0 $aVendor-supplied metadata.
504 $aIncludes bibliographical references and index.
505 0 $aCover; Chemical Warfare Toxicology Volume 2: Management of Poisoning; Preface; References to Material in The National Archives; Contents; Chapter 1 -- Treatment of Nerve Agent Poisoning; 1.1 Introduction; 1.2 OP Compounds; 1.2.1 General Remarks That Are Relevant for Therapy; 1.2.2 Toxicology of OP Compounds; 1.2.2.1 Toxicokinetic Aspects Relevant for Therapy; 1.2.2.2 Toxicodynamics of Nerve Agents; 1.2.2.2.1 Reactions of Nerve Agents with AChE.OP compounds, i.e. nerve agents and pesticides, inhibit serine esterases such as AChE (E.C. ...
505 8 $a1.2.2.2.2 Binding of Nerve Agents to Other Targets.As highly reactive compounds, nerve agents are able to interact with a variety of prote...1.3 Protective Measures and Decontamination; 1.4 Clinical Picture of Nerve Agent Poisoning; 1.4.1 Acute Nerve Agent Poisoning; 1.4.1.1 Central Nervous System; 1.4.1.2 Autonomic Nervous System; 1.4.1.2.1 Sympathetic Nervous System.Nicotinic ACh receptors are located at paravertebral sympathetic ganglions. In response to the pregan...
505 8 $a1.4.1.2.2 Parasympathetic Nervous System.ACh is the primary neurotransmitter of the parasympathetic nervous system and neurotransmission o...1.4.1.3 Somatic Nervous System; 1.4.1.4 Conclusion; 1.4.2 Intermediate Syndrome; 1.4.3 Organophosphate Induced Delayed Neuropathy; 1.5 Pretreatment; 1.6 Differences Between Nerve Agent and OP Compound Pesticide Poisoning; 1.7 Therapeutic Regimen of Nerve Agent Poisoning; 1.7.1 General Considerations; 1.7.2 Atropine; 1.7.2.1 Self and Buddy Aid; 1.7.2.2 Treatment by Medical Specialists; 1.7.3 Oximes; 1.7.3.1 General Background
505 8 $a1.7.3.2 Effectiveness of Oximes in Nerve Agent Poisoning1.7.3.3 Interaction with Persisting Poison Load; 1.7.3.4 Oxime Dosing Strategies; 1.7.3.5 Monitoring of Oxime Therapy; 1.7.3.6 Obidoxime; 1.7.3.7 Pralidoxime; 1.7.3.8 HI-6; 1.7.3.9 Benzodiazepines; 1.7.3.10 Magnesium; 1.7.3.11 Alkalinization by Sodium Bicarbonate; 1.7.3.12 Supportive Treatment; 1.8 Summary and Outlook; References; Chapter 2 -- Nerve Agents: Catalytic Scavengers as an Alternative Approach for Medical Countermeasures; 2.1 Introduction; 2.2 The Scavenger Concept; 2.3 Endogenous Bioscavengers; 2.4 Stoichiometric Scavengers
505 8 $a2.5 Pseudo-Catalytic Scavengers2.6 Catalytic Scavengers; 2.7 Requirements for Operational Catalytic Scavengers; 2.8 Potential Enzymes; 2.8.1 Phosphotriesterases; 2.8.1.1 Bacterial PTEs; 2.8.1.2 Human Paraoxonase; 2.8.1.3 Other Mammalian PTEs; 2.8.2 Engineered ChEs and CaEs; 2.8.3 Oxidases; 2.8.3.1 Glutathione S-Transferases; 2.8.3.2 Laccases; 2.9 Catalytic Antibodies; 2.10 Artificial Enzymes; 2.11 Future Directions; References; Chapter 3 -- Nicotinic Receptors as Targets for Nerve Agent Therapy; 3.1 Introduction; 3.2 Current Therapy for Nerve Agent Poisoning
520 $aThis book provides an up-to-date treatise on the on-going research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning.
650 0 $aChemical weapons$xHealth aspects.
650 7 $aMEDICAL / Pharmacology$2bisacsh
655 4 $aElectronic books.
700 1 $aWorek, Franz,$eeditor.
700 1 $aJenner, John$c(Of Defence Science and Technology Laboratory (Great Britain)),$eeditor.
700 1 $aThiermann, Horst,$eeditor.
776 08 $iPrint version:$aBlack, Robin$tChemical Warfare Toxicology$dCambridge : Royal Society of Chemistry,c2016$z9781782628033
830 0 $aIssues in toxicology ;$vno. 27.
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio12335740$zACADEMIC - Chemistry & Chemical Engineering
852 8 $blweb$hEBOOKS