MARC Record from marc_columbia

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008 141020t20152015fluadf ob 001 0 eng d
035 $a(OCoLC)ocn893977422
035 $a(NNC)15102623
040 $aUAB$beng$erda$epn$cUAB$dOCLCO$dUIU$dCAUOI$dCRCPR$dOCLCQ$dYDXCP$dN$T$dCUV$dIDEBK$dOCLCF$dOCLCQ$dDEBBG$dYDX$dIN0$dOCLCO$dOCLCQ$dSAV$dUAB$dIOG$dD6H$dERL$dOCLCQ$dU3W$dINT$dOCLCQ$dWYU$dOCLCO$dOCLCA$dVT2$dTYFRS$dLEAUB$dOCLCQ$dITD$dWURST$dOCLCO$dOCL$dOCLCQ
019 $a901235244$a961936142$a962430909$a1003499425$a1004052305$a1066440449$a1077293641$a1084412674
020 $a9781466594876$q(electronic bk.)
020 $a146659487X$q(electronic bk.)
020 $a1322633991
020 $a9781322633992
020 $z9781466594869
020 $z1466594861
024 8 $a11633579
035 $a(OCoLC)893977422$z(OCoLC)901235244$z(OCoLC)961936142$z(OCoLC)962430909$z(OCoLC)1003499425$z(OCoLC)1004052305$z(OCoLC)1066440449$z(OCoLC)1077293641$z(OCoLC)1084412674
037 $a694681$bMIL
050 4 $aQP86$b.V35 2015
060 4 $a2014 M-623
060 4 $aWT 104
072 7 $aMED$x075000$2bisacsh
072 7 $aSCI$x036000$2bisacsh
082 04 $a612.67$bV159
084 $aMED008000$aSCI049000$aTEC012000$2bisacsh
049 $aZCUA
100 1 $aValentine, R. C.$q(Raymond Carlyle),$d1936-$eauthor.
245 10 $aHuman longevity :$bomega-3 fatty acids, bioenergetics, molecular biology, and evolution /$cRaymond C. Valentine, David L. Valentine.
264 1 $aBoca Raton :$bTaylor & Francis,$c[2015]
264 4 $c©2015
300 $a1 online resource
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
588 0 $aPrint version record.
504 $aIncludes bibliographical references and index.
505 0 $aSection 1. Introduction to the science of human aging -- section 2. Darwinian selection of membranes enabling longevity -- section 3. Revised mitochondrial membrane hypothesis of aging -- section 4. Many mechanisms have evolved to protect human mitochondrial membranes, enabling longevity.
520 $a"Human cells are protected from the ravages of aging by defensive systems including novel mechanisms against membrane oxidation introduced in this book. The book proposes a unified concept in which aging cells faced with declining energy production by mitochondria and the relatively high cost of protecting membranes against oxidation are triggered by energy stress to activate programmed cellular death. It includes case histories illustrating the duality of polyunsaturated membranes in aging and longevity. It also explains the relationship between membrane unsaturation and longevity leading to a unified concept of aging."--$cProvided by publisher
520 $a"This book is built on the proposition that we age as our mitochondria age. We suggest a revised version of Harman's famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. It is well known that cellular death or apoptosis is triggered by energy stress or oxidative stress. There is convincing data showing that as mitochondria age mitochondrial DNA (mtDNA) accumulates mutations decreasing energy output. Protecting highly unsaturated mitochondrial membranes against oxidative stress also consumes an extraordinary amount of energy"--$cProvided by publisher
650 0 $aAging$xGenetic aspects.
650 0 $aMitochondria.
650 0 $aOxidative stress.
650 0 $aOmega-3 fatty acids$xHealth aspects.
650 0 $aOmega-3 fatty acids.
650 12 $aAging$xphysiology
650 2 $aOxidative Stress
650 22 $aCellular Senescence$xphysiology
650 22 $aFatty Acids, Omega-3
650 22 $aMitochondria
650 6 $aVieillissement$xAspect génétique.
650 6 $aMitochondries.
650 6 $aStress oxydatif.
650 6 $aAcides gras oméga 3.
650 7 $aMEDICAL$xPhysiology.$2bisacsh
650 7 $aSCIENCE$xLife Sciences$xHuman Anatomy & Physiology.$2bisacsh
650 7 $aOmega-3 fatty acids.$2fast$0(OCoLC)fst01045664
650 7 $aAging$xGenetic aspects.$2fast$0(OCoLC)fst00800307
650 7 $aMitochondria.$2fast$0(OCoLC)fst01024016
650 7 $aOmega-3 fatty acids$xHealth aspects.$2fast$0(OCoLC)fst01045665
650 7 $aOxidative stress.$2fast$0(OCoLC)fst01049566
653 00 $averouderen
653 00 $aaging
653 00 $amoleculaire biologie
653 00 $amolecular biology
653 00 $aomega-3 fatty acids
653 00 $abioenergetics
653 00 $aevolutie
653 00 $aevolution
653 00 $amitochondria
653 10 $aMolecular Biology (General)
653 10 $aMoleculaire biologie (algemeen)
700 1 $aValentine, David L.,$eauthor.
776 08 $iPrint version :$aValentine, R.C. (Raymond Carlyle), 1936-$tHuman longevity.$dBoca Raton : CRC Press, Taylor & Francis Group, [2015]$z9781466594869$w(DLC) 2014010535$w(OCoLC)870289678
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio15102623$zTaylor & Francis eBooks
852 8 $blweb$hEBOOKS