MARC Record from marc_columbia

LEADER: 05510cam a2200673 i 4500
001 15139440
005 20220501002345.0
006 m o d
007 cr |||||||||||
008 190615r20191980flu ob 001 0 eng d
035 $a(OCoLC)on1104656861
035 $a(NNC)15139440
040 $aYDX$beng$erda$epn$cYDX$dN$T$dTYFRS$dEBLCP$dOCLCF$dUKAHL$dOCLCQ$dK6U$dOCLCO
020 $a0429264178$q(electronic bk.)
020 $a9780429264177$q(electronic bk.)
020 $a9780429554735$q(electronic bk.)
020 $a0429554737$q(electronic bk.)
020 $a9780429563676$q(electronic bk. ;$qMobipocket)
020 $a0429563671$q(electronic bk. ;$qMobipocket)
020 $a9780429559204$q(electronic bk. ;$qEPUB)
020 $a0429559208$q(electronic bk. ;$qEPUB)
035 $a(OCoLC)1104656861
037 $a9780429264177$bTaylor & Francis
050 4 $aRM301.55
072 7 $aMED$x071000$2bisacsh
072 7 $aMED$x008000$2bisacsh
072 7 $aMMG$2bicssc
082 04 $a615.7$223
049 $aZCUA
100 1 $aDutton, G. F.,$d1924-2010,$eauthor.
245 10 $aGlucuronidation of drugs and other compounds /$cGeoffrey J. Dutton.
264 1 $aBoca Raton :$bCRC Press,$c2019.
300 $a1 online resource
336 $atext$btxt$2rdacontent
337 $acomputer$bc$2rdamedia
338 $aonline resource$bcr$2rdacarrier
490 1 $aCRC revivals
500 $aOriginally published in 1980.
504 $aIncludes bibliographical references and index.
520 $aPublished in 1980: In a previous publication on glucuronic acid both free and conjugated, the author expressed the hope that glucuronic acid studies over the following few years might expand vigorously. The have expanded, and none more vigorously that the study of biosynthesis of simple glucuronides.
545 0 $aG.J. Dutton is Professor of Pharmacological Biochemistry in the University of Dundee, Scotland.
505 0 $aCover; Title Page; Copyright Page; Preface; Author; Table of Contents; PART I -GLUCURONIDATION, GLUCURONIDES, AND STUDIES ON UDPGLUCURONYLTRANSFERASE IN VITRO; Chapter 1: Introduction -- The Biological Function of Glucuronidation; I. What Glucuronidation Is; II." Detoxication" Reactions; III. Distinctive Aspects of the Phase 2 Reactions of Detoxication; IV. The Concept of Detoxication; V. Xenobiotics and Evolution; VI. Competition by Xenobiotics in Routine Glucuronidation; A. General; B. Competition for Materials; C. Competition for Enzyme Sites; VII. Why Glucuronidation is a Major Pathway
505 8 $aVIII. Analogous GlycosidationIX. Metabolic Role of Glucuronidation; A. General; B. Metabolic Role of Steroid Glucuronides; C. Metabolic Role of Other Glucuronides; 1. Absorption; 2. Binding of Toxic Glucuronides; 3. Role of the Hydrolysis of Glucuronides in Their Metabolism; X. Additional Notes; Chapter 2: Structure and Properties of Glucuronides; I. Chemical Structures Glucuronidated; II. Chemical Properties of Glucuronides; A. O-Glucuronides; 1. Aryl-O- (Phenolic) Glucuronides; 2. Aryl- or Alkyl-O- (Enolic) Glucuronides; 3. Alkyl-O- Glucuronides
505 8 $a4. Acyl-O- Glucuronides ("Ester Glucuronides ")B. S-Glucuronides; C. N-Glucuronides; D. C-Glucuronides; III. Physicochemical Properties of Glucuronides; Chapter 3: Mechanism of Glucuronidation; I. Historical Background; A. Work up to 1950; B. Isolation of UDPGlucuronic Acid and Identification of UDPGlucu- ronyltransferase; II. Glucuronidation Involving Sugar Nucleotides; A. Specificity of Sugar Nucleotides as Glucuronyl D onors; B. Lipid Acceptors of Glucuronic Acid; C. Transglucuronylation with UDPGlucuronyltransferase; III. Glucuronidation Not Involving Sugar Nucleotides
505 8 $aA. Transglucuronylation with Other EnzymesB. Nonenzymic Glucuronidation; IV. Additional Notes; Chapter 4: Location of UDPGlucuronyltransferase in the Cell; I. Introduction; II. Location of UDPGlucuronyltransferase Among Cellular Fractions; A. General; B. Distribution Among Rough and Smooth Endoplasmic Reticulum of the Liver Cell; C. Occurrence in " Microsomal Fractions" of Extrahepatic Tissues; D. Occurrence in Nuclear Envelope; E. Occurrence in Other Cell Fractions; 1. Mitochondria; 2. Cytoplasm; 3. Golgi Apparatus and Plasma Membranes; F. Occurrence in Nonparenchymal Liver Cells
505 8 $aIII. Location of UDPGlucuronyltransferase Within the MembraneIV. Additional Notes; Chapter 5: Factors Affecting UDPGlucuronyltransferase Activity In Vitro; I. Latency and Activation: Introduction; A. Latency; 1. Latency -- an Artifact or Not?; 2. Evidence from Comparison of Transferase Activity with Over- all Glucuronidation; 3. Evidence from Kinetic Studies; 4. Evidence from Nuclei; II. Activation and Inhibition Procedures; A. Mechanical Disruption; B. Temperature; C. Storage; D. Centrifugation; E. Surfactants; F. Chaotropic Agents; G. Organic Solvents
650 0 $aDrugs$xMetabolism.
650 0 $aGlucuronic acid$xSynthesis.
650 6 $aMédicaments$xMétabolisme.
650 6 $aAcide glucuronique$xSynthèse.
650 7 $aMEDICAL$xPharmacology.$2bisacsh
650 7 $aMEDICAL$xBiochemistry.$2bisacsh
650 7 $aDrugs$xMetabolism.$2fast$0(OCoLC)fst00898845
650 7 $aGlucuronic acid$xSynthesis.$2fast$0(OCoLC)fst00943711
655 0 $aElectronic books.
655 4 $aElectronic books.
830 0 $aCRC revivals.
856 40 $uhttp://www.columbia.edu/cgi-bin/cul/resolve?clio15139440$zTaylor & Francis eBooks
852 8 $blweb$hEBOOKS